The impact of plasma preparations and their storage time on short-term posttransfusion mortality

Norda, Rut; Andersson, Therése; Edgren, Gustaf; Nyrén, Olof; Reilly, Marie

doi:10.1097/ta.0b013e31824657c4

Cited by 18 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, this is the largest study to date to compare clinical outcomes of trauma patients in the United States receiving LQP vs. FFP. A large population-based study of Swedish patients (n = 84,986), nontrauma exclusive, compared mortality rates in patients receiving FFP (n = 212,541 transfused units) to patients receiving LQP (n = 142,169 transfused units), and found 19% higher odds of mortality in the FFP group 17 . However, mortality association was confined to the earlier years of the study before the leukoreduction era, thereby possibly propagated by the rapid destruction of thawed remaining leukocytes during the freezing/thawing process in FFP.…”

Section: Discussionmentioning

confidence: 99%

Never-frozen liquid plasma transfusion in civilian trauma: a nationwide propensity-matched analysis

Chehab

Ditillo

Obaid

et al. 2021

J Trauma Acute Care Surg

View full text Add to dashboard Cite

BACKGROUND:Never-frozen liquid plasma (LQP) was found to reduce component waste, decrease health care expenses, and have a superior hemostatic profile compared with fresh frozen plasma (FFP). Although transfusing LQP in hemorrhaging patients has become more common, its clinical effectiveness remains to be explored. This study aims to examine outcomes of trauma patients transfused with LQP compared with thawed FFP. METHODS: Adult (≥18 years) trauma patients receiving early (≤4 hours) plasma transfusions were identified in the Trauma Quality Improvement Program 2017. Patients were stratified into those receiving LQP versus FFP. Propensity-score matching in a 1:2 ratio was performed. Primary outcome measures were mortality and time to first plasma unit transfusion. Secondary outcome measures were major complications and hospital length of stay. RESULTS: A total of 107 adult trauma patients receiving LQP were matched to 214 patients receiving FFP. Mean age was 48 ± 19 years, 73% were male, and median Injury Severity Score was 27 [23-41]. A total of 42% of patients were in shock, 22% had penetrating injuries, and 31% required surgical intervention for hemorrhage control. Patients received a median of 4 [2-6] units of PRBC, 2 [1,3] units of LQP or FFP, and 1 [0-1] unit of platelets. The median time to the first LQP unit transfused was significantly shorter compared with the first FFP unit transfused (54 [28-79] minutes vs. 98 [59-133] minutes; p < 0.001). Rates of 24-hour mortality (2.8% vs. 3.7%; p = 0.664) and in-hospital mortality (16.8% vs. 20.1%; p = 0.481) were not different between the LQP and FFP groups. Similarly, there was no difference in major complications (15.9% vs. 21.5%; p = 0.233) and hospital length of stay (12 [6-21] vs. 12 [6-23] days; p = 0.826). CONCLUSION:Never-frozen liquid plasma is safe and effective in resuscitating trauma patients. Never-frozen liquid plasma has the potential to expand our transfusion armamentarium given its longer storage time and immediate availability.

show abstract

Section: Discussionmentioning

confidence: 99%