The impact of platelet‐rich fibrin (PRF) on delayed tooth replantation: A preliminary animal study

Abstract

The aim of this study was to evaluate the effect of platelet‐rich fibrin (PRF) placed in delayed replantation of mature extracted teeth. Sixteen intentionally extracted teeth in two mature beagle dogs were selected. In one quadrant of each jaw, the extraction sockets were filled with PRF prior to replantation, and the other quadrant served as control without PRF. All extracted teeth underwent endodontic treatment and dried for 60 min. Thereafter, they were replanted with a flexible splint. After 8 weeks, the animals were euthanised, and the histological sections examined. Less inflammatory root resorption was noted in the PRF group compared to the control (P = 0.031). However, there was no significant difference between the two groups with regard to new bone formation, inflammatory status, connective tissue healing and replacement resorption (P > 0.05). Using PRF in the extracted socket before delayed replantation did not provide any significant benefit other than reduced inflammatory root resorption.

Evaluation of guided PDL regeneration with mesenchymal stem cell loaded amniotic membrane scaffold and PRF following delayed replantation of avulsed teeth in dogs

“…PRF's distinct characteristics have made it the focus of study as the sole treatment for avulsed teeth that remained dry for extended periods. In a study published by Behnaz et al (34), the use of PRF alone in avulsed adult dog teeth resulted in less in ammatory root resorption in PRF group in comparison with the control group. However, there was no signi cant difference between the two groups in terms of connective tissue regeneration and replacement resorption.…”

Rescuing “hopeless” avulsed teeth using autologous platelet-rich fibrin following delayed reimplantation: Two case reports

“…root canal intervention. The most effective method to prevent the replacement absorption of roots is to immediately replant or place the tooth in an appropriate storage medium[ 19 , 20 ].…”

“…Thus, PRF supports the regenerative and remodeling environment for a certain period of time[ 28 - 31 ]. These growth factors increase the mitotic activity of periodontal fibroblasts by 20%-37%[ 19 ], thereby improving the proliferation and periodontal differentiation of target cells and further promoting periodontal healing of avulsed teeth[ 15 ]. We also note that when a variety of growth factors act together, synergistic or even antagonistic effects among them cannot be ruled out.…”