The impact of portable high-efficiency particulate air filters on the incidence of invasive aspergillosis in a large acute tertiary-care hospital

Salam, Zakir-Hussain Abdul; Karlin, Rubiyah Binte; Ling, Moi Lin; Yang, Kok Soong

doi:10.1016/j.ajic.2009.09.014

Cited by 45 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Risk factors for IMD in allogeneic HCT recipients include age ; active malignancy ; iron overload ; genetic polymorphisms ; cord blood transplant ; haplo‐identical transplant ; T cell‐depleted transplant ; lymphopenia ; prolonged neutropenia ; acute and chronic GVHD ; receipt of corticosteroids ; graft failure ; post‐engraftment neutropenia ; CMV reactivation ; respiratory viral infections ; and environmental exposure .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients

Atalla

Garnica

Maiolino

et al. 2015

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients

Atalla

Garnica

Maiolino

et al. 2015

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…The costs of HEPA filtration were negligible compared to the significant decrease in the rates of IA infection. 88 Nevertheless, portable HEPA filters can be noisy, and bring physical obstruction for airflow in the room. 39 A more recent study assessed the performance of a portable air purifier (filter efficiency not specified) in a pediatric hospital setting.…”

Section: Filtration In Healthcare Facilitiesmentioning

confidence: 99%

COVID-19 Outbreak and Hospital Air Quality: A Systematic Review of Evidence on Air Filtration and Recirculation

Mousavi

Kananizadeh²,

Martinello

et al. 2020

Environ. Sci. Technol.

116

View full text Add to dashboard Cite

The outbreak of SARS-CoV-2 has made us all think critically about hospital indoor air quality and the approaches to remove, dilute, and disinfect pathogenic organisms from the hospital environment. While specific aspects of the coronavirus infectivity, spread, and routes of transmission are still under rigorous investigation, it seems that a recollection of knowledge from the literature can provide useful lessons to cope with this new situation. As a result, a systematic literature review was conducted on the safety of air filtration and air recirculation in healthcare premises. This review targeted a wide range of evidence from codes and regulations, to peer-reviewed publications, and best practice standards. The literature search resulted in 394 publications, of which 109 documents were included in the final review. Overall, even though solid evidence to support current practice is very scarce, proper filtration remains one important approach to maintain the cleanliness of indoor air in hospitals. Given the rather large physical footprint of the filtration system, a range of short-term and long-term solutions from the literature are collected. Nonetheless, there is a need for a rigorous and feasible line of research in the area of air filtration and recirculation in healthcare facilities. Such efforts can enhance the performance of healthcare facilities under normal conditions or during a pandemic. Past innovations can be adopted for the new outbreak at low-to-minimal cost.

show abstract

“…These studies were conducted in the setting of allogeneic HSCT, where patients are known to be at higher risk of IA 18 . Abdul Salam et al 19 published data supporting the effectiveness of portable HEPA filters in a retrospective study that, in contrast to the present study, included possible IA and that compared incidence rates of IA during pre-installation and a post-installation periods. The air samples were comparable to those analyzed in previous studies in wards equipped with Plasmair 12 …”

Section: Discussionmentioning

confidence: 83%

The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients

Fernandez-Gerlinger

Jannot

Rigaudeau

et al. 2016

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

OBJECTIVE Invasive aspergillosis (IA) is a rare but severe infection caused by Aspergillus spp. that often develops in immunocompromised patients. Lethality remains high in this population. Therefore, preventive strategies are of key importance. The impact of a mobile air decontamination system (Plasmair, AirInSpace, Montigny-le-Bretonneux, France) on the incidence of IA in neutropenic patients was evaluated in this study. DESIGN Retrospective cohort study METHODS Patients with chemotherapy-induced neutropenia lasting 7 days or more were included over a 2-year period. Cases of IA were confirmed using the revised European Organization for Research and Treatment of Cancer (EORTC) criteria. We took advantage of a partial installation of Plasmair systems in the hematology intensive care unit during this period to compare patients treated in Plasmair-equipped versus non-equipped rooms. Patients were assigned to Plasmair-equipped or non-equipped rooms depending only on bed availability. Differences in IA incidence in both groups were compared using Fisher's exact test, and a multivariate analysis was performed to take into account potential confounding factors. RESULTS Data from 156 evaluable patients were available. Both groups were homogenous in terms of age, gender, hematological diagnosis, duration of neutropenia, and prophylaxis. A total of 11 cases of probable IA were diagnosed: 10 in patients in non-equipped rooms and only 1 patient in a Plasmair-equipped room. The odds of developing IA were much lower for patients hospitalized in Plasmair-equipped rooms than for patients in non-equipped rooms (P=.02; odds ratio [OR] =0.11; 95% confidence interval [CI], 0.00-0.84). CONCLUSION In this study, Plasmair demonstrated a major impact in reducing the incidence of IA in neutropenic patients with hematologic malignancies. Infect Control Hosp Epidemiol 2016;37:845-851.

show abstract

The impact of portable high-efficiency particulate air filters on the incidence of invasive aspergillosis in a large acute tertiary-care hospital

Cited by 45 publications

References 28 publications

Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients

Risk factors for invasive mold diseases in allogeneic hematopoietic cell transplant recipients

COVID-19 Outbreak and Hospital Air Quality: A Systematic Review of Evidence on Air Filtration and Recirculation

The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients

Contact Info

Product

Resources

About