The Impact of Postoperative Complications on Short- and Long-Term Health-Related Quality of Life After Total Mesorectal Excision for Rectal Cancer

Kooten, Robert T. van; Akker-Marle, M. Elske van den; Putter, Hein; Kranenbarg, Elma Meershoek-Klein; Velde, Cornelis J.H. van de; Wouters, Michel W.J.M.; Tollenaar, Rob A.E.M.; Peeters, Koen

doi:10.1016/j.clcc.2022.07.004

Cited by 8 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we found that the incidences of postoperative overall complications and major complications in our study patients were 22% and 3%, which was in agreement with previous reports ( 25 – 27 ). In addition, we found that CRC patients with T2DM had significantly higher overall complications and major complications than those without T2DM.…”

Section: Discussionsupporting

confidence: 93%

Marked paper: Type 2 diabetes mellitus indicates increased postoperative complications and poor prognosis in colorectal cancer patients receiving curative surgery

Liu

Zhang²,

Zhou³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

PurposeThis study aimed to evaluate the impact of type 2 diabetes mellitus (T2DM) on the short-term outcomes and long-term survival of patients with colorectal cancer (CRC) who underwent curative resection.MethodsThis study retrospectively included 136 patients (T2DM group) with resectable CRC and T2DM from Jan 2013 to Dec 2017. Propensity score-matched control group consisting of 136 patients (non-T2DM group) were selected from 1143 CRC patients without T2DM. The short-term outcomes and prognosis were compared between the T2DM and non-T2DM group.ResultsA total of 272 patients (136 patients for each group) were included in this study. Patients in T2DM group had higher body mass index (BMI), higher proportion of hypertension and cerebrovascular diseases (P<0.05). T2DM group had more overall complications (P=0.001), more major complications (P=0.003) and higher risk of reoperation (P=0.007) when compared with non-T2DM patients. T2DM patients had longer hospitalization time than non-T2DM (20.7 ± 10.2 vs. 17.5 ± 6.2, P=0.002). As for the prognosis, T2DM patients had worse 5-year overall survival (OS) (P=0.024) and 5-year disease-free survival (DFS) (P=0.019) in all stage. Moreover, T2DM and TNM stage were the independent predictors of OS and DFS for CRC patients.ConclusionsT2DM increases overall complications and major complications, and prolongs the hospitalization time after CRC surgery. In addition, T2DM indicates the poor prognosis of CRC patients. A prospective study with large sample size is required to confirm our findings.

show abstract

Section: Discussionsupporting

confidence: 93%

Marked paper: Type 2 diabetes mellitus indicates increased postoperative complications and poor prognosis in colorectal cancer patients receiving curative surgery

Liu

Zhang²,

Zhou³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…As witnessed from a prior conducted study by our group, patients report that over time their quality of life seems to be returning to preoperative levels, suggesting that they face no or minor challenges or treatment-related health de cits [10]. However, as also shown in the current study and other literature, patients who underwent colorectal cancer treatment may still experience various challenges and health de cits.…”

Section: Discussionsupporting

confidence: 78%

“…Colorectal cancer surgery may lead to a decreased quality of life, as well as decreased daily functioning and decreased physical functioning [9]. However, a previous study of our group showed that quality of life returns to a level similar to the preoperative level one-year after surgery, which seems paradoxical since various treatment-related health de cits may arise [10].…”

Section: Introductionmentioning

confidence: 70%

Patient Perspectives on Consequences of Resectable Colorectal Cancer Treatment: a Qualitative Study

Kooten

Schutte

Staalduinen

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Colorectal cancer is diagnosed in approximately 500,000 patients each year in Europe, leading to a high number of patients having to cope with the consequences of resectable colorectal cancer treatment. As treatment options tend to grow, more information on these treatments’ effects is needed to properly engage in shared decision-making. This study aims to explore the impact of resectable colorectal cancer treatment on patients’ daily life. Methods: Patients (≥18 years) who underwent an oncological colorectal resection between 2018 and 2021 were selected. Purposeful sampling was used to include patients who differ in age, comorbidity, (neo-)adjuvant therapy, postoperative complications and stoma presence. Semi-structured interviews were conducted, guided by a topic guide. Interviews were fully transcribed and subsequently thematically analyzed using the framework approach. Analyses were done by using the predefined themes: 1) daily life and activities, 2) psychological functioning, 3) social functioning, 4) sexual functioning and 5) healthcare experiences. Results: Sixteen patients with a follow-up between 0.6 and 4.4 years after surgery were included in this study. Participants reported several challenges they experience due to poor bowel functioning, stoma presence, chemotherapy-induced neuropathy, fear of recurrence and sexual dysfunction, however, they were reported not to interfere much with daily life. Conclusion: Colorectal cancer treatment leads to several challenges and treatment-related health deficits. This is often not recognized by generic patient-reported outcome measures, but the findings on treatment-related health deficits presented in this study, contain valuable insights which might contribute to improving colorectal cancer care, shared decision making and value based healthcare.

show abstract

“…A prior study conducted by our group found that patients reported that, over time, their quality of life seems to return to preoperative levels, suggesting that they face either no treatment-related health deficits or minor challenges only [11]. However, as found in the current study and in other literature, patients who underwent colorectal cancer treatment may still experience various challenges and health deficits.…”

Section: Discussionsupporting

confidence: 69%

Patient perspectives on consequences of resection for colorectal cancer: A qualitative study

et al. 2023

Self Cite

View full text Add to dashboard Cite

BackgroundColorectal cancer is diagnosed in approximately 500,000 patients each year in Europe, leading to a high number of patients having to cope with the consequences of resection for colorectal cancer. As treatment options tend to grow, more information on the effects of these treatments is needed to engage in shared decision‐making. This study aims to explore the impact of resection for colorectal cancer on patients' daily life.MethodsPatients (≥18 years of age) who underwent an oncological colorectal resection between 2018 and 2021 were selected. Purposeful sampling was used to include patients who differed in age, comorbidity conditions, types of (neo)adjuvant therapy, postoperative complications and the presence/absence of a stoma. Semi‐structured interviews were conducted, guided by a topic guide. Interviews were fully transcribed and subsequently thematically analysed using the framework approach. Analyses were carried out using the following predefined themes: (1) daily life and activities; (2) psychological functioning; (3) social functioning; (4) sexual functioning; and (5) healthcare experiences.ResultsSixteen patients with a follow‐up period of between 0.6 and 4.4 years after surgery were included in this study. Participants reported several challenges experienced because of poor bowel function, a stoma, chemotherapy‐induced neuropathy, fear of recurrence and sexual dysfunction. However, they reported these as not interfering much with daily life.ConclusionColorectal cancer treatment leads to several challenges and treatment‐related health deficits. This is often not recognized by generic patient‐reported outcome measures, but the findings on treatment‐related health deficits presented in this study contain valuable insights which might contribute to improving colorectal cancer care, shared decision making and value‐based health care.

show abstract

The Impact of Postoperative Complications on Short- and Long-Term Health-Related Quality of Life After Total Mesorectal Excision for Rectal Cancer

Cited by 8 publications

References 48 publications

Marked paper: Type 2 diabetes mellitus indicates increased postoperative complications and poor prognosis in colorectal cancer patients receiving curative surgery

Marked paper: Type 2 diabetes mellitus indicates increased postoperative complications and poor prognosis in colorectal cancer patients receiving curative surgery

Patient Perspectives on Consequences of Resectable Colorectal Cancer Treatment: a Qualitative Study

Patient perspectives on consequences of resection for colorectal cancer: A qualitative study

Contact Info

Product

Resources

About