The impact of posttraumatic symptoms and comorbid mental disorders on the health-related quality of life in treatment-seeking PTSD patients

Pagotto, Luiz Felipe; Mendlowicz, Mauro V.; Coutinho, Evandro Silva Freire; Figueira, Ivan; Luz, Mariana Pires; Araújo, Alexandre Xavier Gomes de; Berger, William

doi:10.1016/j.comppsych.2015.01.002

Cited by 77 publications

(49 citation statements)

References 35 publications

(36 reference statements)

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“…This study demonstrated that the greater the severity of PTSD symptoms the worst the quality of life. Even though the results point out in the same direction, the present study differs from the investigation of Pagotto et al 34 because of the use of a clinical sample with 65 people. On this regard, it is important to emphasize the relevance of the present investigation in revealing data originated from non--specific groups and in presenting a sample size that allows generalizations.…”

Section: Discussioncontrasting

confidence: 55%

“…In this sense, there is a lack of literature regarding quality of life related to PTSD amongst civilian populations originated from locations without history of disasters. One recently-published Brazilian study sought to identify the impact of the severity of PTSD symptoms on quality of life of individuals who were victims of urban violence 34 . This study demonstrated that the greater the severity of PTSD symptoms the worst the quality of life.…”

Section: Discussionmentioning

confidence: 99%

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Posttraumatic stress disorder: prevalences, comorbidities and quality of life in a community sample of young adults

Medeiros

Silva

Souza

et al. 2015

J. bras. psiquiatr.

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objectives: To verify the prevalence of current posttraumatic stress disorder (PTSD) in young adults, the occurrence of comorbidities and its association with quality of life. Methods: This is a cross-sectional population-based study. The targeted population consisted on indivi duals aged 18 to 24 years old, who lived in the urban area of Pelotas-RS, Brazil. Cluster sampling was applied. PTSD and its comorbidities were assessed using the Mini International Neuropsychiatric Interview (MINI 5.0), whereas quality of life was evaluated with the eight domains of the Medical Outcomes Survey Short-form General Health Survey (SF-36). results: A total of 1,762 young adults were selected. The prevalence of PTSD was 2.1% and current episode of depression was the most prevalent comorbidity (71.9%). The individuals with PTSD had lower scores in all domains of quality of life. conclusion: These findings indicate that PTSD is associated with other psychopathologies, especially depression, and it has a substantial impact over quality of life in a sample of young adults. reSUMo objetivos: Verificar a prevalência de transtorno de estresse pós-traumático (TEPT) atual em adultos jovens, a ocorrência de comorbidades e sua associação com a qualidade de vida. Mé-todos: Estudo transversal de base populacional, tendo como população-alvo indivíduos de 18 a 24 anos de idade, residentes na zona urbana do município de Pelotas-RS, Brasil. A seleção amostral foi realizada por conglomerados, com um pulo de três domicílios entre os selecionados. O TEPT e as comorbidades foram avaliados pela Mini International Neuropsychiatric Interview (MINI 5.0), enquanto a qualidade de vida foi mensurada por oito domínios da SF-36. resultados: No total, 1.762 jovens foram selecionados. A prevalência de TEPT foi de 2,1%; entre esses, a depressão foi o transtorno mais ocorrente (71,9%). Em todos os domínios da qualidade de vida, os jovens com TEPT obtiveram escores mais baixos. conclusão: Os achados indicam que o TEPT se encontra associado a outras psicopatologias, principalmente a depressão, e apresenta substancial impacto na qualidade de vida em uma amostra de jovens.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Posttraumatic stress disorder: prevalences, comorbidities and quality of life in a community sample of young adults

Medeiros

Silva

Souza

et al. 2015

J. bras. psiquiatr.

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“…The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) divides pathological anxiety into three main categories of disorders, including obsessivecompulsive and related disorders, trauma-and stressor-related disorders, and anxiety disorders 8 . The precipitating stimuli differ among these diagnoses, however in all cases, the somatic, cognitive, and behavioral manifestations of anxiety interfere with normal functioning and lead to substantial economic and personal burdens [9][10][11] .…”

Section: Anxiety Disorders: Too Much Of a Normal Thingmentioning

confidence: 99%

Resolving the neural circuits of anxiety

2015

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Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with absolute certainty the subjective experience of a rodent, rodent models hold promise in dissecting wellconserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety, and thereby provides a roadmap for future therapeutic development.3

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“…Studies with military personnel and veterans reveal a joint incidence of PTSD and mild traumatic brain injury for almost 48% of cases (Chapman and Diaz-Arrastia, 2014). Similarly, there is considerable comorbidity between PTSD and a major neurocognitive disorder (Doctor et al, 2011; Maksimovskiy et al, 2014; Pagotto et al, 2015), including a high association between PTSD and a significant decline in physical and mental health (Blakeley and Jansen, 2013; Pacella et al, 2013). The essential feature for the start of a PTSD diagnosis is the appearance of symptoms after exposure to one or more traumatic events, either directly or indirectly experienced, such as witnessing something experienced by others.…”

Section: Post-traumatic Stress Disordermentioning

confidence: 99%

Executive Dysfunctions: The Role in Attention Deficit Hyperactivity and Post-traumatic Stress Neuropsychiatric Disorders

et al. 2016

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Executive functions (EFs) is an umbrella term for various cognitive processes controlled by a complex neural activity, which allow the production of different types of behaviors seeking to achieve specific objectives, one of them being inhibitory control. There is a wide consensus that clinical and behavioral alterations associated with EF, such as inhibitory control, are present in various neuropsychiatric disorders. This paper reviews the research literature on the relationship between executive dysfunction, frontalsubcortical neural circuit changes, and the psychopathological processes associated with attention deficit hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD). A revision on the role of frontal-subcortical neural circuits and their presumable abnormal functioning and the high frequency of neuropsychiatric symptoms could explain the difficulties with putting effector mechanisms into action, giving individuals the necessary tools to act efficiently in their environment. Although, neuronal substrate data about ADHD and PTSD has been reported in the literature, it is isolated. Therefore, this review highlights the overlapping of neural substrates in the symptomatology of ADHD and PTSD disorders concerning EFs, especially in the inhibitory component. Thus, the changes related to impaired EF that accompany disorders like ADHD and PTSD could be explained by disturbances that have a direct or indirect impact on the functioning of these loops. Initially, the theoretical model of EF according to current neuropsychology will be presented, focusing on the inhibitory component. In a second stage, this component will be analyzed for each of the disorders of interest, considering the clinical aspects, the etiology and the neurobiological basis. Additionally, commonalities between the two neuropsychiatric conditions will be taken into consideration from the perspectives of cognitive and emotional inhibition. Finally, the implications and future prospects for research and interventions in the area will be outlined, with the intention of contributing scientific reference information that encompasses the knowledge and understanding of executive dysfunction and its relationship with these treated disorders.

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The impact of posttraumatic symptoms and comorbid mental disorders on the health-related quality of life in treatment-seeking PTSD patients

Cited by 77 publications

References 35 publications

Posttraumatic stress disorder: prevalences, comorbidities and quality of life in a community sample of young adults

Posttraumatic stress disorder: prevalences, comorbidities and quality of life in a community sample of young adults

Resolving the neural circuits of anxiety

Executive Dysfunctions: The Role in Attention Deficit Hyperactivity and Post-traumatic Stress Neuropsychiatric Disorders

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