The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials

Farhadfar, Nosha; Ahn, Kwang Woo; Bo-Subait, Stephanie; Logan, Brent R.; Stefanski, Heather E.; Hsu, Jack W.; Panch, Sandhya R.; Confer, Dennis L.; Liu, Hien; Badawy, Sherif M.; Beitinjaneh, Amer; Díaz, Miguel Ángel; Hildebrandt, Gerhard; Kelkar, Amar H.; Lazarus, Hillard M.; Murthy, Hemant S.; Preussler, Jaime M.; Schears, Raquel M.; Sharma, Akshay; Poel, Marjolein van der; Bruce, Jessica G.; Pulsipher, Michael A.; Shaw, Bronwen E.; Wingard, John R.; Switzer, Galen E.

doi:10.1016/j.jtct.2022.05.042

Cited by 7 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single studies reported no associations between donor comorbidity expressed as the Charlson Comorbidity Index and CD34 + cell concentration (35) and between previous blood donation or physical activity and CD34 + cell yield (43). One study reported no association between self-reported health-related quality of life and CD34 + cell yield (47).…”

Section: Resultsmentioning

confidence: 99%

Scoping review of factors associated with stem cell mobilisation and collection in allogeneic stem cell donors

Peck,

Knapp-Wilson,

Burley

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: There is a large inter-individual variation in CD34+ cell yield after G-CSF mobilisation and collection from peripheral blood in healthy allogenic haematopoietic stem cell donors. Donor characteristics including gender and age, baseline and precollection blood results, mobilisation factors and collection factors have been associated with CD34+ cell concentration in the blood after G-CSF mobilisation and/or CD34+ cell yield after collection. Since the literature reporting these associations is heterogeneous, we here clarify the determinants of CD34+ cell concentration and yield through a scoping literature review. Materials and Methods: MEDLINE, Embase, PubMed and Stem Cell Evidence were searched for studies published between 2000 and 2023. The inclusion criteria were studies of allogeneic donors undergoing G-CSF mobilisation and peripheral blood stem cell collection (PBSC). Eligible studies assessed an outcome of mobilisation or collection efficacy, indicated by the blood CD34+ cell concentration after 4 or 5 days of G-CSF treatment and/or CD34+ cell yield in the first PBSC collection after mobilisation. Included studies assessed associations between these outcomes and donor factors(such as age, gender, weight, ethnicity), mobilisation factors (G-CSF scheduling or dose), collection factors (venous access, processed blood volume) and laboratory factors (such as blood cell counts at baseline and after mobilisation). Results: The 51 eligible studies evaluated between 23 and 20,884 donors. 43 studies were retrospective, 32 assessed blood CD34+ cell concentration after mobilisation and 37 assessed CD34+ cell yield. In studies that recorded both outcomes, blood CD34+ cell concentration always predicted CD34+ cell yield. The most frequently assessed factor was donor age for which most studies reported that younger donors had a higher blood CD34+ cell concentration and CD34+ cell yield. Non-European ancestry was associated with both higher blood CD34+ cell concentration and yield although this finding was inconsistent. Conclusions: There remains poor consensus about the best predictors of blood CD34+ cell concentration and yield that requires further prospective study, particularly of the role of donor ancestry. The current focus on donor gender as a major predictor may require re-evaluation

show abstract

Section: Resultsmentioning

confidence: 99%

Scoping review of factors associated with stem cell mobilisation and collection in allogeneic stem cell donors

Peck,

Knapp-Wilson,

Burley

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…45 Particularly, related donors may describe a failure to return to a baseline quality of life or protracted discomfort twelve months after the donation. 8, 46,47 The supportive care for donors at this stage should use a multi-disciplinary approach with a focus on quality-of-life recuperation. Physical therapists, social workers and psychotherapists are tasked to collaborate with primary care teams to guide donors back towards a high quality-of-life existence.…”

Section: Long-term Complicationsmentioning

confidence: 99%

Supportive Care of Hematopoietic Stem Cell Donors

Rennert,

Smith M,

Cormier

et al. 2024

Clinical Hematology International

View full text Add to dashboard Cite

Supportive care needs for hematopoietic stem cell recipients have been studied. Less is known about the care needs of stem cell donors. Care challenges arise at donor selection, preparation for the donation, the donation procedure and the immediate and long-term after-care. Care needs were analyzed for 1,831 consecutive bone marrow and peripheral stem cell donors at MedStar Georgetown University Hospital between January 2018 and August 2023 in support of a review of the current literature. During the selection, related donors may experience psychological pressures affecting their motivation, while donation centers may be willing to accept co-morbidities in these donors which might preclude donation in unrelated peers. For bone marrow donations, it is important to select donors not only according to optimal genetic matching criteria but also according to suitable donor/recipient weight ratios, to facilitate sufficient stem cell yields. During the donation preparation phase, side effects and complications related to stem cell stimulation must be anticipated and managed for peripheral cell donors, while the pros and cons of autologous blood donation should be evaluated carefully for bone marrow donors. The stem cell donation procedure itself carries potential side effects and complications as well. Peripheral cell donors may require a central line and may encounter hypocalcemia, thrombocytopenia, and anemia. Bone marrow donors face risks associated with anesthesia, blood loss and pain. Post-procedure care focusses on pain management, blood cell recovery and the psychological support necessary to regain a high quality-of-life existence. Hematopoietic stem donors are giving part of themselves to save another’s life. They deserve comprehensive supportive care to accompany them throughout the donation process.

show abstract

Psychological and physical side effects during G-CSF mobilization in related donors of allo-HCT

Cai,

Jin,

Lai

et al. 2024

Ann Hematol

View full text Add to dashboard Cite

The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials

Cited by 7 publications

References 21 publications

Scoping review of factors associated with stem cell mobilisation and collection in allogeneic stem cell donors

Scoping review of factors associated with stem cell mobilisation and collection in allogeneic stem cell donors

Supportive Care of Hematopoietic Stem Cell Donors

Psychological and physical side effects during G-CSF mobilization in related donors of allo-HCT

Contact Info

Product

Resources

About