The impact of preparation parameters on sustained release aceclofenac microspheres: A design of experiments

Deshmukh, Rameshwar K.; Naik, Jitendra

doi:10.1016/j.apt.2014.10.004

Cited by 33 publications

(15 citation statements)

References 52 publications

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“…Numerical optimization technique using the desirability function approaching 1 for obtaining optimized formulation indicated desirable range for independent variables A and B to get the optimum response for further investigation. SEM study revealed that the discrete, uniformly shaped spherical microspheres were hour (Y4) showed that as the drug: polymer ratio was varied towards higher side, the drug release retarded from the formulations as diffusional path length for drug release increased while with increase in stirring speed the interfacial area per unit volume increased, so, the drug release also increased [8,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…With the progressive research in formulation development for designing an optimum formulation with desired performance characteristics, several Statistical experimental designs such as factorial design, response surface methodology have emerged as powerful and systematic tools in multiple factor optimizations in fewer experimental trials [1][2][3][4]. Therefore, quality by design in this research protocol has been built-in by using response surface methodology by applying the most popular design of experiment, Central Composite Design (CCD); that describes optimal liaison among the process variables and responses for preparation of dosage form with desired performance characteristics [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Potential of Eudragit for Development of Microparticles of Water Soluble Drug Using Quality by Design Approach

Sharma¹,

Seth²

2019

Int J App Pharm

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Objective: In the present protocol, employability of polymethacrylate polymer Eudragit RS100 for development of microparticles of water-soluble drug with desired values of response variables was investigated by central composite optimization design through the application of Design Expert ® Methods: The microparticles were developed by emulsion solvent evaporation process employing Eudragit RS100. Two effective independent variables drug: polymer ratio and stirring speed were selected to assess performance prospective of Eudragit on mean particle size, entrapment efficiency, percent yield and drug release in 12 h of microparticles. Thirteen batches generated by the software were prepared and subjected to different characterization test parameters obligatory for the evaluation of formulation. Validation of optimization model and Statistical interpretation of results was done using Analysis of Variance (ANOVA). software (Series DX10).Results: ANOVA indicated that the independent variables had a significant effect on response variables. Optimized formulation demonstrated close agreement amongst experimental and predicted responses with high desirability factor. In vitro drug liberation study for optimized formulation proposed a sustained release of drug from microparticles. Conclusion:In conclusion, the optimization technique was imperative in indicating the efficient applicability of Eudragit RS100 polymer in controlling the drug release of hydrophilic drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Eudragit for Development of Microparticles of Water Soluble Drug Using Quality by Design Approach

Sharma¹,

Seth²

2019

Int J App Pharm

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“…Drug content was determined with the help of double beam UV‐visible spectrophotometer (U‐2900, Hitachi, Japan) by measuring absorbance at 266 nm wavelengths. To study the mechanism of drug release from the carrier system, zero order, first order, Higuchi equation and Korsmeyer–Peppas equation were selected as a model dependent approach to characterize the dissolution profile . These selected models are often used to describe the drug release from the polymeric system when the mechanism is not well known or when more than one type of release phenomenon is involved.…”

Section: Characterizationmentioning

confidence: 99%

“…To study the mechanism of drug release from the carrier system, zero order, first order, Higuchi equation and Korsmeyer-Peppas equation were selected as a model dependent approach to characterize the dissolution profile. [61][62][63] These selected models are often used to describe the drug release from the polymeric system when the mechanism is not well known or when more than one type of release phenomenon is involved. The model which gave the highest coefficient of determination (R 2 ) was considered to be the most suitable kinetic model for describing the release of FMT from the carrier system.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

et al. 2019

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This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.

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“…The 106 investigation of dynamic vapour sorption of EM (and the related 107 modulated differential scanning calorimetry studies) was included 108 as well as an experimental design to optimize disintegration time 109 and tensile strength of tablets. Design of experiments approach is 110 often applied to optimize pharmaceutical powders [36]. after 100 rounds on ten tablets.…”

mentioning

confidence: 99%

Development and tableting of directly compressible powder from electrospun nanofibrous amorphous solid dispersion

Démuth

Farkas

Szabó

et al. 2017

Advanced Powder Technology

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The impact of preparation parameters on sustained release aceclofenac microspheres: A design of experiments

Cited by 33 publications

References 52 publications

Exploring the Potential of Eudragit for Development of Microparticles of Water Soluble Drug Using Quality by Design Approach

Exploring the Potential of Eudragit for Development of Microparticles of Water Soluble Drug Using Quality by Design Approach

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

Development and tableting of directly compressible powder from electrospun nanofibrous amorphous solid dispersion

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