The impact of primary tumor resection on overall survival in patients with colorectal carcinoma and unresectable distant metastases: A prospective cohort study

Abstract

Resection of colorectal tumor in primary CRC patients with non-resectable distant metastasis gives significant survival advantage without increasing postoperative mortality compared with non-resection.

Survival outcomes following primary tumor resection for patients with incurable metastatic colorectal carcinoma: Experience from a single institution

“…Our key finding of the association of PTR with improved OS, regardless of chemotherapy administration, is interesting. This result is in consistent with other retrospective studies and meta‐analyses that have shown a survival benefit of PTR. In our cohort the decision for elective palliative PTR was based on multidisciplinary tumor board discussions.…”

“…The use of modern combination chemotherapy has led to an improved clinical response with only a minority of patients developing tumor complications requiring surgical intervention for palliation . However, retrospective studies have postulated that PTR can not only prevent tumor complications but also play a role in prolonging survival . The reason for this is not well understood.…”

“…The results of recent retrospective studies that have compared the clinical significance of PTR in CRC patients with unresectable metastases have thus far yielded inconclusive results . In a large cohort study using instrumental variable analysis, PTR was associated with improved OS .…”

Distant Liver Metastases as a Major Factor Influencing Survival in Patients with Colorectal Cancer

“…6 For its part, HMD is a major factor, Blue "+" -NMCRC ("Censored") Green "+" -HMD ("Censored") associated with survival of patients with colorectal cancer. 1 In the present study, comparing patients with liver metastatic disease (surgically treated) and those without, we found no signifi cant differences in terms of sex, age, body mass index and the presence of co-morbidity. Surgical treatment is still the main pillar in the treatment of HMD.…”

“…1 Colorectal cancer (CRC) is not an exception in this regard. Given the extremely high frequency which keeps increasing recently and the great many cases of late-diagnosed patients with advanced stage of cancer with distant dissemination, it is absolutely necessary that in-depth research in the treatment of metastatic colorectal cancer be carried out.…”