The Impact of Proton Pump Inhibitor Compliance on Health-Care Resource Utilization and Costs in Patients with Gastroesophageal Reflux Disease

Abstract

Both health-care resource use and costs were reduced after initiation of PPI therapy. Additional reductions from the pre-PPI period were further observed by compliance with PPI therapy.

Predictors of adherence among Alzheimer's disease patients receiving oral therapy

“…Finally, the claims data do not provide the reasons for patients either stopping or switching from their index AD treatment. Use of claims data for the purpose of evaluating medication adherence is an acceptable form of research as evidenced by the number of published studies [42][43][44][45][46][47] .…”

Economic Evaluations of Gastroesophageal Reflux Disease Medical Management

“…One additional article was obtained via expert opinion that was not identified with the literature search [8]. Thus, eighteen articles were included in the final analysis [8–25] (Figure 1); their general characteristics are shown in Table 1.…”

“…Only one did not explicitly identify the study as an economic evaluation in the title [16]. The majority of missing items were specific methods including mention of discount rates (n=4) [16,23–25] and study parameters (n=2) [16,25]. Three articles did not disclose funding sources [22–24] and four did not disclose conflicts of interest [17,20,22,23].…”

“…Only one used a retrospective cohort design in assessing the incremental annualized healthcare costs of compliant and non-compliant PPI users [25]. Fifteen articles (78%) included comparisons of different PPI strategies (n=7, [16–21,23]) or PPI therapy with surgery (n=8, [8–15,24]).…”

“…UK NHS, US Medicare) [9–17,19–23,26]. One study used an employer cost perspective [18], one used a societal perspective [24], and one used a third party payer perspective [25]. More articles reported cost outcomes in US dollars (n=7) than other individual currencies (Table 1).…”