The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Huyck, Karen L.; Panhuysen, Carolien; Cuenco, Karen T.; Zhang, Jingmei; Goldhammer, Hilary; Jones, Emlyn S.; Somasundaram, P. R.; Lynch, Allison M.; Harlow, Bernard L.; Lee, Hang; Stewart, Elizabeth A.; Morton, Cynthia C.

doi:10.1016/j.ajog.2007.05.038

Cited by 83 publications

(61 citation statements)

References 19 publications

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“…For example, the incidence of hysteromyoma in African females is three times as high as that in Caucasian females (13). Also, compared with other ethnicities, African females with hysteromyoma are younger and have larger lesions, with hysteromyomas that grow faster (12,15). The incidence of hysteromyoma in females of African descent is higher than in individuals of other ethnicities, including Hispanic and Asian individuals (11,15,16).…”

Section: Discussionmentioning

confidence: 95%

“…Certain studies have shown that the incidence of hysteromyoma varies among populations of different ethnicities (11)(12)(13)(14)(15)(16). For example, the incidence of hysteromyoma in African females is three times as high as that in Caucasian females (13).…”

Section: Discussionmentioning

confidence: 99%

“…Also, compared with other ethnicities, African females with hysteromyoma are younger and have larger lesions, with hysteromyomas that grow faster (12,15). The incidence of hysteromyoma in females of African descent is higher than in individuals of other ethnicities, including Hispanic and Asian individuals (11,15,16). Certain studies have indicated that other risks, such as family history, smoking, drinking, hypertension and weight increase, can increase the risk of hysteromyoma, in addition to the risk associated with ethnicity (12,14,16,17).…”

Section: Discussionmentioning

confidence: 99%

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MED12 mutation in patients with hysteromyoma

Wang

Chen

et al. 2015

Oncology Letters

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Abstract. Mediator Complex Subunit 12 (MED12) is a subunit of the mediator complex, which is believed to regulate global, as well as gene-specific, transcription. It has been reported that MED12 is mutated at high frequency in hysteromyoma. Recent studies have also shown that MED12 presents with different mutation frequencies in hysteromyoma patients of different populations. However, there are few studies with regard to the MED12 gene mutation in hysteromyoma patients in the Chinese Han population. In the present study, the MED12 mutations of 171 patients with hysteromyoma were analyzed; the results showed that 93 patients exhibited different MED12 mutations, including 131G→T, 131G→A, 130G→A, 146C→T, 130G→A, 130G→C, 128A→C, 130G→T, 127Ins27, 118_132Del15, 117_134Del18, 131_148Del18 and 141_165Del15. The mutation frequency was similar to that found in individuals of African descent or individuals of other non-Caucasian ethnicities, and lower than that in the Finnish or North American populations. Further analysis of 141 patients whose hysteromyoma was measured showed that the mutation frequency of MED12 in patients with large hysteromyomas was significantly lower than that in those with small hysteromyomas. These results suggested that MED12 mutation was important in the development of hysteromyomas in the Chinese Han population and that the size of the hysteromyoma may negatively correlate with the mutation frequency of MED12. This study supplemented current information on MED12 mutations in different races and may aid in developing personalized diagnoses for patients with hysteromyoma in the future.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MED12 mutation in patients with hysteromyoma

Wang

Chen

et al. 2015

Oncology Letters

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“…In the United States, uterine leiomyomas occur two to nine times more often in black than in white women of all ages, and are associated with more serious symptoms in blacks, who are diagnosed at younger ages and have higher hysterectomy rates than whites 5,6,7,8,9,10,11 . The underlying mechanisms of this color/race inequality remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Does life-course socioeconomic position influence racial inequalities in the occurrence of uterine leiomyoma? Evidence from the Pro-Saude Study

Boclin

Faerstein

Szklo³

2014

Cad. Saúde Pública

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“…Epidemiological data on risk factors for the development of UL primarily originate from studies conducted in the United States. In these studies, higher frequencies of tumors stood out among black women 4,[23][24][25][26] , those exposed to factors associated with the increase in ovarian hormones (estrogen and progesterone), those undergoing hormonal therapy 27 , those consuming greater amounts of red meat and sausages 28 , those aged between 40 and 50 years 4,29 , those who had had an early menarche [30][31][32] , those with a high BMI 31,[33][34][35][36] and fat percentage 37 , and those with an increase in weight during adulthood 33,34,38 . On the other hand, lower frequencies of tumors were found in women who practiced physical activities 39 , smokers 30,33,40,41 , those with a higher number of children [30][31]36,42 , those who had reached menopause 36 and those who consumed greater amounts of fruits, vegetables and fish 28,35 .…”

Section: Introductionmentioning

confidence: 99%

Prevalência de diagnóstico médico auto-relatado de miomas uterinos em população brasileira: Padrões demográficos e socioeconômicos no Estudo Pró-Saúde *

Boclin

Faerstein

2013

Rev. bras. epidemiol.

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Estado do Rio de Janeiro -UERJ. Rua São Francisco Xavier, 524, Pavilhão João Lyra Filho, 6º andar / blocos E, e 6º andar, sala 6003, Maracanã, 20550-900 Rio de Janeiro, RJ, Brasil. E-mail: karine.boclin@gmail.com Abstract Introduction: Uterine leiomyomas (UL) are considered the most common tumors of the female reproductive system. However, there are few epidemiological studies about this condition in Brazil. Aim: To estimate the prevalence of self-reported history of UL according to demographic and socioeconomic characteristics, and to markers of access to health care. Methods: We analyzed data from 1,733 university employees who participated at the baseline waves of the Pro-Saude Study (1999)(2000)(2001), in relation to three outcomes: (1) self-reported medical diagnosis of UL, (2) UL with symptoms prior to diagnosis, and (3) cases with hysterectomy due to UL. Prevalence and 95% confidence intervals (95% CI) were estimated in relation to strata of variables related to demographic (age, color/race) and socioeconomic characteristics (education, income) and of markers of access to health care (Pap smear, breast clinical exam and private health insurance status). Results: The prevalence of medically-diagnosed UL was 23.3% (95% CI -21.3, 25.2), the UL with symptoms prior to diagnosis of 13.3% (95% CI -11.7, 15.0) and hysterectomy due to UL, 8.4% (95% CI -7.5, 10.3). Among participants younger than 45 years old, higher prevalence was observed among women with worse socioeconomic conditions and of black color/race. Among those with 45 years or more, there was higher prevalence among women with better access to health care. Conclusion: In this study population of Brazilian women, UL is a relevant health problem, and its prevalence and associated socio-demographic gradients are similar to those observed in other countries.

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The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Cited by 83 publications

References 19 publications

MED12 mutation in patients with hysteromyoma

MED12 mutation in patients with hysteromyoma

Does life-course socioeconomic position influence racial inequalities in the occurrence of uterine leiomyoma? Evidence from the Pro-Saude Study

Prevalência de diagnóstico médico auto-relatado de miomas uterinos em população brasileira: Padrões demográficos e socioeconômicos no Estudo Pró-Saúde *

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