The Impact of Race/Ethnicity on the Clinical Epidemiology of Autoimmune Hepatitis

Wong, Robert J.; Gish, Robert G.; Frederick, Richard; Bzowej, Natalie; Frenette, Catherine

doi:10.1097/mcg.0b013e318228b781

Cited by 68 publications

(73 citation statements)

References 31 publications

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“…In the current series, NASH was the second leading cause of liver disease in Hispanics with HCC, accounting for 34% of cases. Consistent with prior studies, we found Hispanics demonstrated notable differences in cirrhosis etiologies compared to non-Hispanics, including higher rates of NASH[43,44] and autoimmune cirrhosis[45], and lower incidence of HCV cirrhosis[46]. Additionally, we observed that NASH was particularly prevalent in Hispanic women compared to Hispanic men (72.7% vs 21.9%).…”

Section: Discussionsupporting

confidence: 89%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

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AIMTo compare features of hepatocellular carcinoma (HCC) in Hispanics to those of African Americans and Whites.METHODSPatients treated for HCC at an urban tertiary medical center from 2005 to 2011 were identified from a tumor registry. Data were collected retrospectively, including demographics, comorbidities, liver disease characteristics, tumor parameters, treatment, and survival (OS) outcomes. OS analyses were performed using Kaplan-Meier method.RESULTSOne hundred and ninety-five patients with HCC were identified: 80.5% were male, and 22% were age 65 or older. Mean age at HCC diagnosis was 59.7 ± 9.8 years. Sixty-one point five percent of patients had Medicare or Medicaid; 4.1% were uninsured. Compared to African American (31.2%) and White (46.2%) patients, Hispanic patients (22.6%) were more likely to have diabetes (P = 0.0019), hyperlipidemia (P = 0.0001), nonalcoholic steatohepatitis (NASH) (P = 0.0021), end stage renal disease (P = 0.0057), and less likely to have hepatitis C virus (P < 0.0001) or a smoking history (P < 0.0001). Compared to African Americans, Hispanics were more likely to meet criteria for metabolic syndrome (P = 0.0491), had higher median MELD scores (P = 0.0159), ascites (P = 0.008), and encephalopathy (P = 0.0087). Hispanic patients with HCC had shorter OS than the other racial groups (P = 0.020), despite similarities in HCC parameters and treatment.CONCLUSIONIn conclusion, Hispanic patients with HCC have higher incidence of modifiable metabolic risk factors including NASH, and shorter OS than African American and White patients.

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Section: Discussionsupporting

confidence: 89%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

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“…14 Available adult data indicate an incidence varying from 0.67 to 2 cases per 100 000 people. [15][16][17] Ethnic background has been reported as a key factor in clinical presentation and outcomes for patients with AIH 18,19 ; however, this finding is not universal. 20 In the present national study, our primary aim was to determine the incidence of AIH in children and adolescents in Canada and to describe its clinical characteristics and natural history.…”

Section: What This Study Addsmentioning

confidence: 69%

Incidence and Characteristics of Autoimmune Hepatitis

et al. 2015

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“…And the individuals with Asian background revealed a lower prevalence of liver cirrhosis and a poorer survival outcome compared with the Hispanics. 19 As for the liver function test, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels are increasing constantly or repeatedly, usually reach 3-10 times the upper limit of normal (ULN), and are more significantly increased compared with the changes in bilirubin, alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GT) levels. The parameters of cholestasis in AIH patients indicate the possibility of overlap syndrome.…”

Section: Clinical Featuresmentioning

confidence: 99%

Autoimmune hepatitis: Unveiling faces

Zhu

Han

2015

J of Digest Diseases

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Autoimmune hepatitis (AIH) is a complex multifactorial liver disease with unknown etiology. It may be induced by certain triggers that cause immune disorders and autoimmune attack in genetically susceptible individuals, which ultimately results in chronic persistent interface inflammation of the liver. The diagnosis of AIH is made based on comprehensive evaluation score system. All AIH patients should receive interventions and the mainstay therapy is prednisone alone or in combination with azathioprine. Further exploratory researches on refractory AIH have been developed. Liver transplantation is still the only effective option for patients with decompensated cirrhosis or hepatic failure.

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The Impact of Race/Ethnicity on the Clinical Epidemiology of Autoimmune Hepatitis

Cited by 68 publications

References 31 publications

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Incidence and Characteristics of Autoimmune Hepatitis

Autoimmune hepatitis: Unveiling faces

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