Key Messages• Florida is highly vulnerable to climate-sensitive hazards (e.g. sea level rise, heat waves, storm surge, and hurricanes), which have a wide range of human health effects.• The health effects can be direct, such as storm/temperature related illnesses, injuries, and deaths; or indirect, such as waterborne, food-borne, and vector-borne diseases; or take social and economic pathways, such as stress and mental illness.• The health effects exhibit substantial regional disparities across the state.• Policies focused on health surveillance and research on knowledge gaps between human exposure to the hazards and health effects are much needed.