The impact of red and processed meat consumption on cancer and other health outcomes: Epidemiological evidences

Boada, Luís D.; Henríquez-Hernández, Luis Alberto; Luzardo, Octavio P.

doi:10.1016/j.fct.2016.04.008

Cited by 163 publications

(102 citation statements)

References 90 publications

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“…The epidemiologic literature usually classifies the meat consumed as “red”, “white”, and processed meat. All meats obtained from mammals are red meats because they contain more myoglobin than white meat (obtained from chicken or fish) . “Processed meat” includes all types of meat products, which have undergone a process to extend their shelf life and which have been mixed with ingredients such as salt …”

Section: The Association Between Individual Components Of the MD Andmentioning

confidence: 99%

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi

Salomone²,

Mlynarsky

2017

Liver International

209

162

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Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines. The MD has an established superiority in long term weight reduction over low fat diet, but it improves metabolic status and steatosis even without it.However, the effect on liver inflammation and fibrosis was tested only in few observational studies with positive results. Furthermore, considering the strong association between NAFLD and diabetes and CVD, the MD has a highly established advantage in prevention of these diseases, demonstrated in randomized clinical trials. The individual components of the MD such as olive oil, fish, nuts, whole grains, fruits, and vegetables, have been shown to beneficially effect or negatively correlate with NAFLD, while consumption of components that characterize a Western dietary pattern as soft drinks, fructose, meat and saturated fatty acids have been shown to have detrimental association with NAFLD. In this review we will cover the epidemiological evidence and the plausible molecular mechanisms by which the MD as a whole and each of its components can be of benefit in NAFLD.

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Section: The Association Between Individual Components Of the MD Andmentioning

confidence: 99%

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi

Salomone²,

Mlynarsky

2017

Liver International

209

162

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“…The International Agency for Research on Cancer classified consumption of red meat as “probably carcinogenic to humans” and of processed red meat as “carcinogenic to humans” based on the assessment of more than 800 epidemiological studies in many countries, different continents, with diverse ethnicities and diets [91]. Other studies came to the same or slightly different results [92], [93], [94], [95], [96], [97], [98], [99], [100]. At present it is impossible to determine whether pig meat transmits tumor-inducing viruses or other infectious agents to customers, whether these results are due to chemical carcinogens or both.…”

Section: Impact On Animal and Public Healthmentioning

confidence: 99%

Xenotransplantation — A special case of One Health

Denner

2017

One Health

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The chronic shortage of human transplants to treat tissue and organ failure has led to the development of xenotransplantation, the transplantation of cells, tissues and organs from another species to human recipients. For a number of reasons, pigs are best suited as donor animals. Successful, routine xenotransplantation would have an enormous impact on the health of the human population, including the young, who sometimes require a replacement organ or islet cells, but especially the elderly, who more often suffer the consequences of organ failure. The first form of xenotransplantation applied to humans is the use of pig islet cells to treat insulin-dependent diabetes, a procedure that will have a significant economic impact. However, although xenotransplantation using pig cells, tissues and organs may save and prolong the lives of patients, it may also be associated with the transmission of porcine microorganisms to the recipient, eventually resulting in emerging infectious diseases. For this reason, the health of both the donor animals and the human recipients represents a special and sensitive case of the One Health concept. Basic research leading to strategies how to prevent transmission of porcine microorganisms by selection of virus-free animals, treatment of donor pigs by antiviral drugs, vaccines, colostrum deprivation, early weaning, Caesarean delivery, embryo transfer and/or gene editing should be undertaken to supply an increasing number of potential recipients with urgently required transplants. The methods developed for the detection and elimination of porcine microorganisms in the context of xenotransplantation will also contribute to an improvement in the health of pig populations in general and an increase in the quality of meat products. At present, there is evidence for transmission of porcine viruses to humans eating pork and having contact with pigs, however the impact of these viruses on public health is still unknown.

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“…The compound which exhibits a mutagenic activity does possess the carcinogenic potential (Boada et al, 2016[9]). Breakage of DNA strands or alteration in the nitrogenous bases is a domineering characteristic of certain chemicals.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay

Sharif

Akhtar

et al. 2017

EXCLI Journal; 16:Doc593; ISSN 1611-2156

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The impact of red and processed meat consumption on cancer and other health outcomes: Epidemiological evidences

Cited by 163 publications

References 90 publications

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Xenotransplantation — A special case of One Health

Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay

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