The impact of refugees on leishmaniasis in Turkey: a new Syrian/Turkish Leishmania tropica population structure described by multilocus microsatellite typing (MLMT)

Karakuş, Mehmet; Çizmeci, Zeynep; Karabela, Şemsi Nur; Erdoğan, Bilgen; Güleç, Nuray

doi:10.1007/s00436-019-06392-w

Cited by 9 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Europe it is also important to note the impact caused by the influx of refugees mostly from Syria; the high infection rates noticed in refugee camps indicate an increased risk of infection among the local population. [112][113][114][115][116][117][118][119][120][121] In addition, the number of cases of Leishmania/HIV co-infection has increased in recent years. 112 Interestingly, Cannabis sativa plants were consumed by blood-sucking phlebotomine sand flies, the primary vectors of Leishmania, much more frequently than expected (i.e.…”

Section: Leishmaniasis and Malariamentioning

confidence: 99%

Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

Ritter¹,

Zadik-Weiss²,

Almogi-Hazan³

et al. 2020

Rambam Maimonides Med J

View full text Add to dashboard Cite

Section: Leishmaniasis and Malariamentioning

confidence: 99%

Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

Ritter¹,

Zadik-Weiss²,

Almogi-Hazan³

et al. 2020

Rambam Maimonides Med J

View full text Add to dashboard Cite

“…However, social and environmental changes in the last two decades have affected the epidemiology of leishmaniasis in the Mediterranean region and southern Caucasus (Aoun & Bouratbine, 2014; Gradoni, 2018; Sergiev et al, 2018). War in Leishmania endemic Syria since 2011 has led to a rise in the incidence of CL in the country and in neighbourhood following massive migration flows (Muhjazi et al, 2019; Amr et al, 2018; El Safadi et al, 2019; Karakuş, Çizmeci et al, 2019). Moreover, a report has described infection by L. tropica and L. donovani in sand flies from refugee camps in Greece, which highlights the risk of potential spread into other areas of southern Europe where competent vectors are present (Fotakis et al, 2019) The Caucasus has also been subjected to political unrest and leishmaniasis re‐emerged after the dissolution of the Soviet Union, collective economy and health services, and with it the cessation of long‐standing, centralized leishmaniasis control campaigns based on elimination of animal reservoirs, insecticide application and prompt case detection and treatment (Sergiev et al, 2018; Strelkova et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries

Özbel

Töz

Muñoz

et al. 2022

Zoonoses and Public Health

View full text Add to dashboard Cite

Leishmania spp. are sand fly‐borne protozoan parasites causing leishmaniasis in humans and animals. The aim of the study was to analyse the epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia from 2005 to 2020 and evaluate the associated risk for disease emergence in European countries. It is based on an analysis of WHO and OIE reported cases between 2005 and 2020, a review of scientific articles published in SCOPUS between 2009 and 2020 and a questionnaire survey to public health and veterinary authorities in these countries. Endemic Leishmania spp. include L. infantum in the three countries, L. major in Azerbaijan and Turkey and L. tropica and L. donovani in Turkey. Leishmaniasis is reported in humans, animals and sand flies and incidence is spatially and temporarily variable. In the southern Caucasus and particularly in Georgia, reported incidence of human visceral leishmaniasis by L. infantum remains high. However, whilst Georgia experienced a gradual decrease from >4.0 cases per 100,000 population in 2005–09 to 1.13 cases per 100,000 population in 2020, the period with highest incidence in Azerbaijan, which ranged between 0.40 and 0.61 cases per 100,000 population, was 2016–2019, and no cases have so far been reported for 2020. Visceral leishmaniasis in the Southern Caucasus affects mostly young children from deprived urban areas and its closely associated to canine leishmaniasis. Turkey reported cases of visceral leishmaniasis between 2005 and 2012 and in 2016 only, and incidence ranged between 0.02 and 0.05 per 100,000 population. In contrast, the reported annual incidence of cutaneous leishmaniasis in Turkey was much greater and peaked at 7.02 cases per 100,000 population in 2013, associated to imported cases from cutaneous leishmaniasis endemic Syria. Leishmaniasis by L. infantum in Azerbaijan and Georgia represents a regional public and animal health challenge that requires support to improve diagnosis, treatment and control. The unprecedented rise of cutaneous leishmaniasis and the spread of L. tropica and L. donovani in Turkey is an important risk factor for their emergence in Europe, especially in Mediterranean countries where competent vectors are widespread.

show abstract

“…which has become widespread around the world are also considered as atypical cases (Mebrahtu et al, 1993;Siriwardana et al, 2007;Elamin et al, 2008;Lopes et al, 2013;Özbilgin et al, 2017;Thakur et al, 2018). Genomic studies demonstrated that mixed Leishmania infections and interspecies Leishmania hybrids which were promoted by climate change, mass migrations and travels (Dereure et al, 2009;González et al, 2010;Alawieh et al, 2014;King et al, 2015;Karakuş et al, 2019;Lypaczewski and Matlashewski, 2021), render the disease more detrimental for this reason aforementioned complications supposedly have emerged under these factors (Akopyants et al, 2009;Romano et al, 2014;Ferreira et al, 2015;Alves Souza et al, 2019). Since these alterations somehow jeopardize disease control and prevention, to keep up with the biological alterations and to update our knowledge, Leishmania parasites should be investigated from all perspectives, especially involving the ones isolated from patients.…”

Section: Introductionmentioning

confidence: 99%

Comparative proteomic analysis of Leishmania parasites isolated from visceral and cutaneous leishmaniasis patients

et al. 2021

View full text Add to dashboard Cite

Leishmaniasis is an infectious disease in which different clinical manifestations are classified into three primary forms: visceral, cutaneous and mucocutaneous. These disease forms are associated with parasite species of the protozoan genus Leishmania. For instance, Leishmania infantum and Leishmania tropica are typically linked with visceral (VL) and cutaneous (CL) leishmaniasis, respectively; however, these two species can also cause other form to a lesser extent. What is more alarming is this characteristic, which threatens current medical diagnosis and treatment, is started to be acquired by other species. Our purpose was to address this issue; therefore, gel-based and gel-free proteomic analyses were carried out on the species L. infantum to determine the proteins differentiating between the parasites caused VL and CL. In addition, L. tropica parasites representing the typical cases for CL were included. According to our results, electrophoresis gels of parasites caused to VL were distinguishable regarding the repetitive down-regulation on some specific locations. In addition, a distinct spot of an antioxidant enzyme, superoxide dismutase, was shown up only on the gels of CL samples regardless of the species. In the gel-free approach, 37 proteins that were verified with a second database search using a different search engine, were recognized from the comparison between VL and CL samples. Among them, 31 proteins for the CL group and six proteins for the VL group were determined differentially abundant. Two proteins from the gel-based analysis, pyruvate kinase and succinyl-coA:3-ketoacid-coenzyme A transferase analysis were encountered in the protein list of the CL group.

show abstract

The impact of refugees on leishmaniasis in Turkey: a new Syrian/Turkish Leishmania tropica population structure described by multilocus microsatellite typing (MLMT)

Cited by 9 publications

References 28 publications

Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries

Comparative proteomic analysis of Leishmania parasites isolated from visceral and cutaneous leishmaniasis patients

Contact Info

Product

Resources

About