Objectives: We examined the association of bodily pain with lifestyle factors (i.e., obesity, physical activity,sleep duration, sedentary behavior, and alcohol consumption) among African-American adults. Methods:We conducted a cross-sectional study on a convenience sample (N=1408) of African-American adultsin Houston, Texas in 2013-2014. We used multivariable logistic regression to determine the relationshipbetween lifestyle factors and bodily pain, adjusting for age, gender, income, education, employment,chronic conditions, and depression. Results: Overall, 16% of participants reported moderate to extremebodily pain. Body mass index (OR = 1.06 [95% CI 1.04-1.09]) and time spent in sedentary behavior (OR =1.05 [95% CI 1.004-1.10]) were significantly linked to a higher likelihood of reporting moderate to extremebodily pain. Physical activity (OR = 0.63 [95% CI 0.40-0.98]) was significantly linked to a lower likelihood ofreporting moderate to extreme bodily pain. Alcohol consumption and sleep duration were not correlatedwith pain. Conclusions: A relationship exists between lifestyle factors contributing to the burden ofcancer and bodily pain among African Americans. Findings can guide future interventions to reducecancer risk in African Americans through modification of lifestyle behaviors and addressing bodily pain.