In
this study, we synthesized and characterized a silicon phthalocyanine
substituted with 3-hydroxypyridin-2-thione (
SiPc-HDACi
), designed to be a chemophotodynamic therapy agent acting as a histone
deacetylase inhibitor, and we determined its photophysical, photochemical,
and photobiological properties. Next, we evaluated its anticancer
efficacy on MCF-7, double positive and MDA-MB-231, triple negative
breast cancer cell lines, as well as on a healthy human endothelial
cell line (HUVEC). Our results indicate that
SiPc-HDACi
can target nucleoli of cells, effectively inducing apoptosis while
promoting cell cycle arrest thanks to its high singlet oxygen yield
and its histone deacetylase downregulating properties, suggesting
a powerful anticancer effect on breast cancer
in vitro
. Our further studies will be conducted with primary breast cancer
cell culture to give a better insight into the anticancer mechanism
of the compound.