The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis

Abstract

The aim of this study was to investigate the impact of resveratrol supplementation along with non-surgical periodontal treatment on blood glucose, insulin, insulin resistance, triglyceride (TG), and periodontal markers in patients with type 2 diabetes with periodontal disease. In this double-blind clinical trial study, 43 patients with diabetes with chronic periodontitis were participated. Subjects were randomly allocated to intervention and control groups. The intervention and control groups received either 480 mg/day of resveratrol or placebo capsules (two pills) for 4 weeks. Fasting blood glucose, insulin, insulin resistance (homeostasis model assessment of insulin resistance), TGs, and pocket depth were measured in all subjects' pre-intervention and post-intervention. The mean serum levels of fasting insulin and insulin resistance (homeostasis model assessment of insulin resistance) were significantly lower in the intervention group compared with control group (10.42 ± 0.28 and 10.92 ± 0.9; 3.66 ± 0.97 and 4.49 ± 1.56, respectively). There was a significant difference in the mean pocket depth between intervention and control groups (2.35 ± 0.6 and 3.38 ± 0.5, respectively) following intervention. No significant differences were observed in the mean levels of fasting blood glucose and TGs between two groups' post-intervention. It is recommended that resveratrol supplementation may be beneficial as adjuvant therapy along with non-surgical periodontal treatment in insulin resistance and improving periodontal status among patients with diabetes with periodontal disease. Copyright © 2016 John Wiley & Sons, Ltd.

The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial

“…In a study conducted by Elliott et al, fasting insulin and HbA1c were unchanged following 5 g/d resveratrol supplementation (Elliott et al, 2009). There is also another study showing a significant effect of resveratrol on HOMA-IR improvement without significant change on FBS (Zare Javid et al, 2017).…”

“…Although, some studies reached nonsignificant results (Bashmakov et al, 2014;Goh et al, 2014;Timmers et al, 2016). A randomized controlled trial showed no significant effect of 30-day resveratrol treatment on hepatic and peripheral insulin sensitivity (Timmers et al, 2016), while two other studies reported significant beneficial effect on insulin resistance following resveratrol supplementation (Movahed et al, 2013;Zare Javid et al, 2017). Contradictory results prompted us to perform a randomized controlled trial to investigate if resveratrol supplementation affects glycemic control, lipid profile, and body composition in overweight patients with T2DM.…”

Therapeutic applications of resveratrol and its derivatives on periodontitis

“…Recently, a human clinical trial reported by Zare Javid et al . suggested that resveratrol supplementation may be beneficial as adjuvant therapy along with nonsurgical periodontal treatment in insulin resistance and improving the periodontal status in patients with diabetes and periodontal disease …”

Health benefits of resveratrol: Evidence from clinical studies

“…Resveratrol is therefore proposed to manage comorbidity or multimorbidity in the elderly. For example, in T2DM patients with chronic periodontitis, resveratrol significantly reduced insulin and insulin resistance while improving the periodontal status with an insignificant effect on the fasting blood glucose and triglycerides levels . At least 25% of diabetic patients suffer from foot ulcers, which can become chronic and severe .…”