The Impact of Rosmarinic Acid on the Oxidative Stress Metabolism: Evaluation Protocol Based on Glutathione-Dependent and -Independent Antioxidant Enzymes

Aydemir, Duygu; Ulusu, Nuriye Nuray

doi:10.1007/978-1-0716-3938-2_16

Methods and Protocols in Food Science

2024

DOI: 10.1007/978-1-0716-3938-2_16

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The Impact of Rosmarinic Acid on the Oxidative Stress Metabolism: Evaluation Protocol Based on Glutathione-Dependent and -Independent Antioxidant Enzymes

Duygu Aydemir,

Nuriye Nuray Ulusu

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2024

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DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs

Aydemir,

Karabulut,

Barlas

et al. 2024

Toxicol Ind Health

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Di(2-ethylhexyl) phthalate (DEHP), a widely utilized plasticizer in various consumer products, is classified as an endocrine disruptor and has been implicated in numerous adverse health effects, including oxidative stress, inflammation, and metabolic disturbances. Despite the growing body of literature addressing the systemic effects of DEHP, the specific influence of DEHP-induced oxidative stress on mitochondrial function within detoxification organs, particularly the liver and kidneys, remains largely unexplored. This study evaluated the effects of DEHP exposure (0, 100, 200, and 400 mg/kg/day) on mitochondrial oxidative stress, trace elements, and mineral metabolism associated with signaling pathways in the liver and kidneys of rats. Altered mitochondrial oxidative stress status was indicated by impaired glucose 6-phosphate dehydrogenase (G6PD), 6-phosphoglucerate dehydrogenase (6-PGD), glutathione reductase (GR), glutathione s-transferase (GST), and glutathione peroxidase (GPx) activities, along with significant disruptions in essential minerals and trace elements, including Na, Mg, Cu, Zn, and Fe. Key oxidative stress signaling pathways, such as NF-κB, Akt, STAT3, and CREB, glucose, and tissue homeostasis, displayed dose-dependent responses to DEHP, indicating complex regulatory mechanisms. This study represents the first comprehensive investigation into DEHP-induced mitochondrial dysfunction, highlighting its effects on oxidative stress metabolism, trace element homeostasis, and cellular signaling pathways in detoxification organs. These findings provide novel insights into the mitochondrial mechanisms underlying DEHP toxicity and underscores the need for further research into the implications of plasticizer exposure on human health.

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DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs

Aydemir,

Karabulut,

Barlas

et al. 2024

Toxicol Ind Health

View full text Add to dashboard Cite

show abstract

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The Impact of Rosmarinic Acid on the Oxidative Stress Metabolism: Evaluation Protocol Based on Glutathione-Dependent and -Independent Antioxidant Enzymes

Cited by 1 publication

References 153 publications

DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs

DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs

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