The impact of S100b and persistent high levels of neuron-specific enolase on cognitive performance in elderly patients after cardiopulmonary bypass

Baranyi, Andreas; Rothenhäusler, Hans-Bernd

doi:10.3109/02699052.2012.750751

Cited by 14 publications

(12 citation statements)

References 34 publications

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“…CPB patients may face major treatment-related cognitive performance decline. Persistently high levels of neuron-specific enolase might be a useful biomarker to identify patients with cognitive performance deficits at discharge; while no significant correlation between S100β levels and impaired cognitive function have been found [ 90 ] . High-dose propofol triggered short-term neuroprotection and long-term neurodegeneration in neuronal cultures from rat embryos [ 91 ] .…”

Section: Discussionmentioning

confidence: 99%

S100 and S100β: biomarkers of cerebral damage in cardiac surgery with or without the use of cardiopulmonary bypass

Yuan¹

2014

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveThe present study is to describe the clinical impact of S100 and S100β for the evaluation of cerebral damage in cardiac surgery with or without the use of cardiopulmonary bypass (CPB).MethodsQuantitative results of S100 and S100β reported in the literature of the year range 1990-2014 were collected, screened and analyzed.ResultsCerebrospinal fluid and serum S100 levels showed a same trend reaching a peak at the end of CPB. The cerebrospinal fluid/serum S100 ratio decreased during CPB, reached a nadir at 6 h after CPB and then increased and kept high untill 24 h after CPB. Serum S100 at the end of CPB was much higher in infant than in adults, and in on-pump than in off-pump coronary artery bypass patients. ∆S100 increased with age and CPB time but lack of statistical significances. Patients receiving an aorta replacement had a much higher ∆S100 than those receiving a congenital heart defect repair. Serum S100β reached a peak at the end of CPB, whereas cerebrospinal fluid S100 continued to increase and reached a peak at 6 h after CPB. The cerebrospinal fluid/serum S100β ratio decreased during CPB, increased at the end of CPB, peaked 1 h after CPB, and then decreased abruptly. The increase of serum S100β at the end of CPB was associated with type of operation, younger age, lower core temperature and cerebral damages. ∆S100β displayed a decreasing trend with age, type of operation, shortening of CPB duration, increasing core temperature, lessening severity of cerebral damage and the application of intervenes. Linear correlation analysis revealed that serum S100β concentration at the end of CPB correlated closely with CPB duration.ConclusionS100 and S100β in cerebrospinal fluid can be more accurate than in the serum for the evaluations of cerebral damage in cardiac surgery. However, cerebrospinal fluid biopsies are limited. But serum S100β and ∆S100β seem to be more sensitive than serum S100 and ∆S100. The cerebral damage in cardiac surgery might be associated with younger age, lower core temperature and longer CPB duration during the operation. Effective intervenes with modified CPB circuit filters or oxygenators and supplemented anesthetic agents or priming components may alleviate the cerebral damage.

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Section: Discussionmentioning

confidence: 99%

S100 and S100β: biomarkers of cerebral damage in cardiac surgery with or without the use of cardiopulmonary bypass

Yuan¹

2014

Revista Brasileira De Cirurgia Cardiovascular

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“…Delirium is associated with higher plasma NSE concentrations and mortality in critically ill patients 28 . A trend towards an association between persistently elevated plasma NSE levels and cognitive impairment at discharge in patients following cardiopulmonary bypass surgery 29 has been reported. Others found no significant difference in plasma NSE between delirium and control groups 30 .…”

Section: Neuronal Injury/death Biomarkers In Ad and Deliriummentioning

confidence: 96%

“…34 In keeping with these observations, a low concentration of S100B has been proposed to be used as a risk stratification marker to rule out delirium. 35 However, there are studies that did not detect any difference in plasma S100B levels in patients with and without cognitive impairment following cardiopulmonary bypass 27,28 or found that CSF S100B levels were lower in patients with persistent delirium compared with those with probable AD. 26 A recent study of older hip fracture patients found that serum S100B was not associated with postoperative delirium, and although S100B was associated with cognitive decline or death in the first year after hip fracture, this was observed only in participants without perioperative delirium.…”

Section: S100bmentioning

confidence: 99%

Delirium and Alzheimer disease: A proposed model for shared pathophysiology

Fong

Vasunilashorn

Libermann

et al. 2019

Int J Geriat Psychiatry

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“…Baranyi and Jones found that high levels of serum NSE were closely related to cognitive impairment in the elderly after surgery. 7,8 Schmidt et al found significantly increased NSE in the CSF of Alzheimer's disease (AD) patients, and NSE was positively correlated with tau. 19 Tau hyperphosphorylation, an important pathological feature of AD, which may lead to cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…A vast number of studies have proved that excessive NSE levels are closely related to post-operative cognitive decline (POCD) in the elderly. [7][8][9] Hence, this biomarker is expected to be a good indicator of mild cognitive impairment in patients with diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

Yu¹,

Liu²,

Li³

et al. 2020

DMSO

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Diabetic retinopathy (DR) can increase the risk of mild cognitive impairment (MCI), which has been confirmed by previous researches. With the frequent occurrence of MCI in patients with DR, the early detection of MCI has become a research hot-spot. The aim of this study was to investigate the relationship between neuron-specific enolase (NSE) and MCI in patients with DR. Patients and Methods: A total of 124 patients with DR, including 56 MCI patients and 68 normal cognition patients, were recruited in this cross-sectional study. The demographic and clinical data of patients were collected through questionnaires. Serum NSE was measured using electrochemiluminescence immunoassay. The Minimum Mental State Examination (MMSE) scale was used to evaluate the cognitive function of the participants. Results: Compared with the normal cognition group, serum NSE levels and HbA1c levels in the MCI group were higher, while MMSE scores and educational level were lower (P<0.05). Serum NSE levels were significantly negatively correlated with MMSE total score, attention and calculation score, and language score (P<0.05). After adjusting for confounding factors, serum NSE still increased the MCI risk in DR patients (OR:1.606, 95CI%:1.264-2.041, P<0.001). The areas under the receiver operating characteristics (ROC) curves (AUC) of the crude model and the adjusted model were 0.75 and 0.73, respectively. Conclusion: A high serum NSE level is an independent risk factor for MCI in DR patients. In addition, serum NSE is expected to be a potential biomarker in DR patients with MCI.

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The impact of S100b and persistent high levels of neuron-specific enolase on cognitive performance in elderly patients after cardiopulmonary bypass

Abstract: Persistently high levels of NSE might be a useful biomarker to identify patients with cognitive performance impairments, while no significant correlation between levels of S100b and impaired cognitive function were found.

Cited by 14 publications

References 34 publications

S100 and S100β: biomarkers of cerebral damage in cardiac surgery with or without the use of cardiopulmonary bypass

S100 and S100β: biomarkers of cerebral damage in cardiac surgery with or without the use of cardiopulmonary bypass

Delirium and Alzheimer disease: A proposed model for shared pathophysiology

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

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