The impact of sarcopenia on short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer

Hisada, Hiroyuki; Tsuji, Yosuke; Obata, Miho; Cho, Rina; Nagao, Sayaka; Miura, Yuko; Mizutani, Hiroya; Ohki, Daisuke; Yakabi, Seiichi; Takahashi, Yu; Sakaguchi, Yoshiki; Kakushima, Naomi; Yamamichi, Nobutake; Fujishiro, Mitsuhiro

doi:10.1007/s00535-022-01923-2

Cited by 14 publications

(45 citation statements)

References 34 publications

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“…Subsequently, ten studies were excluded for the following reasons: four did not include the GNRI in the analyses, three did not provide survival data, and three recruited overlapping patients. Ultimately, 10 studies recruiting 5,834 patients (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) with GC were included in this meta-analysis (Figure 1, Table 1).…”

Section: Study Retrievalmentioning

confidence: 99%

“…Basic characteristics of the included studies are summarized in Table 1. All 10 studies (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) were of a retrospective design. Nine studies were conducted in Japan (13)(14)(15)(16)(18)(19)(20)(21)(22) and one in Korea (17).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…All 10 studies (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) were of a retrospective design. Nine studies were conducted in Japan (13)(14)(15)(16)(18)(19)(20)(21)(22) and one in Korea (17). The total sample size was 5,834, ranging from 106 to 1,166.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The total sample size was 5,834, ranging from 106 to 1,166. Six studies recruited patients with stages I-III GC (13,14,16,17,19,21), and four studies enrolled patients with early GC (15,18,20,22). Five studies selected 92 as the cut-off value of the GNRI (14,15,17,18,22), two selected 98 (16,21), and three selected 94.8 (13), 96 (20), and 97 (19) as their respective GNRI cut-off values.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…It is favored to assess nutritional status and disease prognosis in older patients (11,12). Previous studies have explored the prognostic significance of the GNRI in patients with GC; however, the results were inconsistent (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). For example, some studies have confirmed the independent prognostic role of the GNRI for survival in GC (13,14,16).…”

Section: Introductionmentioning

confidence: 99%

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Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

Liu

et al. 2023

Front. Surg.

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BackgroundRecent studies have explored the prognostic value of the geriatric nutritional risk index (GNRI) in patients with gastric cancer (GC), but the results are controversial. We aimed to systemically identify the association between the GNRI and prognosis in GC using a meta-analysis.MethodsThe databases of PubMed, Web of Science, Cochrane Library, and Embase were searched until September 25, 2022. Pooled hazard ratios and the corresponding 95% confidence intervals (CIs) were used to estimate the prognostic value of the GNRI in GC. Odds ratios (ORs) and 95% CIs were used to assess the correlation between the GNRI and clinicopathological characteristics of GC.ResultsTen studies including 5,834 patients with GC were included in this meta-analysis. The merged results indicated that a low pretreatment GNRI was associated with inferior overall survival (hazard ratio = 1.21, 95% CI = 1.12–1.30, P < 0.001) and worse cancer-specific survival (hazard ratio = 2.21, 95% CI = 1.75–2.80, P < 0.001) for GC. Moreover, a low GNRI was significantly associated with an advanced pathological stage (OR = 2.27, 95% CI = 1.33–3.85, P = 0.003), presence of adjuvant chemotherapy (OR = 1.25, 95% CI = 1.01–1.55, P = 0.040), and tumor location in the lower stomach (OR = 1.33, 95% CI = 1.06–1.65, P = 0.012) in GC. However, there was no significant association between GNRI and sex, tumor differentiation, or lymph node metastasis in patients with GC.ConclusionOur meta-analysis identified that the pretreatment GNRI level was a significant prognostic factor for patients with GC. A low GNRI is associated with worse overall survival and inferior cancer-specific survival in patients with GC.

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Section: Study Retrievalmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

Liu

et al. 2023

Front. Surg.

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High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers

Liu,

Qiu,

Zhang

et al. 2023

J cachexia sarcopenia muscle

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Sarcopenia has been considered an adverse prognostic factor in cancer patients. Intramuscular adipose tissue content, as a new marker of sarcopenia, can effectively reflect skeletal muscle quality. The aim of this study was performed to evaluate the association between high intramuscular adipose tissue content (IMAC) and survival outcomes and postoperative complications in cancer patients. Specific databases, including the Web of Science, Embase and Web of Science, were systematically searched to identify relevant articles evaluating the prognostic value of IMAC in cancer patients. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were utilized for comprehensive analysis. All data analyses were performed using STATA 12.0 software. A total of 25 studies from 24 articles including 5663 patients were enrolled in the study. Meta‐analysis showed that high IMAC was associated with unfavourable overall survival (OS) (HR: 2.21, 95% CI: 1.70–2.86, P < 0.001), relapse‐free survival (RFS) (HR: 1.51, 95% CI: 1.30–1.75, P < 0.001) and disease‐specific survival (DSS) (HR: 1.64, 95% CI: 1.19–2.28, P = 0.003). Subgroup analysis revealed that high IMAC remained an adverse prognostic factor when stratified by different country, treatment methods, cancer type or analysis type. High IMAC had better predictive value for gallbladder carcinoma (GBC) (HR: 3.50, 95% CI: 1.98–6.17, P < 0.001), hepatocellular carcinoma (HCC) (HR: 1.84, 95% CI: 1.45–2.33, P < 0.001), pancreatic cancer (PC) (HR: 2.11, 95% CI: 1.67–2.66, P < 0.001) and colorectal cancer (CRC) (HR: 2.54, 95% CI: 1.27–5.10, P = 0.009). High IMAC was also identified as a significant risk factor for postoperative complications (OR: 2.05, 95% CI: 1.22–3.46, P = 0.007). High IMAC was associated with an adverse prognosis and an increased risk of postoperative complications in cancer patients. IMAC may be a good indicator of sarcopenia.

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Effect of sarcopenia on short-term outcomes of gastric endoscopic submucosal dissection

Tanaka,

Iwatsubo,

Sasaki

et al. 2024

Surg Endosc

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The impact of sarcopenia on short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer

Cited by 14 publications

References 34 publications

Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

Prognostic and clinicopathological value of the geriatric nutritional risk index in gastric cancer: A meta-analysis of 5,834 patients

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers

Effect of sarcopenia on short-term outcomes of gastric endoscopic submucosal dissection

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