The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

Kwon, Chan-Young

doi:10.3390/ijerph20020909

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…There were previous systematic reviews of the associations of HRV parameters with the COVID-19 vaccination [ 66 ] and with the acute COVID-19 infection [ 28 , 51 ]. To our knowledge, this review is the first comprehensive review of the long-term effects of COVID-19 based on HRV parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Although other underlying mechanisms of long COVID include immune dysregulation, gut microbiota imbalance, and autoimmunity, ANS dysfunction is still considered a promising therapeutic target for this clinical condition [ 27 ]. Although there has been a recent systematic review investigating changes in HRV parameters in individuals currently positive for SARS-CoV-2 [ 28 ], there has been no attempt to comprehensively investigate the relationship between HRV parameters and the long-term effects of SARS-CoV-2 infection, including long COVID.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

2023

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Coronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates the long-term association between COVID-19 and HRV parameters. Four electronic databases were searched up to 29 July 2022. We included observational studies comparing HRV parameters (measurement durations: 1 min or more) in participants with and without a history of COVID-19. We used assessment tools developed by the National Heart, Lung, and Blood Institute group to evaluate the methodological quality of included studies. Eleven cross-sectional studies compared HRV parameters in individuals who recovered from acute COVID-19 infection to controls (n = 2197). Most studies reported standard deviation of normal-to-normal intervals (SDNN) and root mean square of the successive differences. The methodological quality of the included studies was not optimal. The included studies generally found decreased SDNN and parasympathetic activity in post-COVID-19 individuals. Compared to controls, decreases in SDNN were observed in individuals who recovered from COVID-19 or had long COVID. Most of the included studies emphasized parasympathetic inhibition in post-COVID-19 conditions. Due to the methodological limitations of measuring HRV parameters, the findings should be further validated by robust prospective longitudinal studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

2023

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“…Дослідження ВСР при COVID-19 проводили як серед госпіталізованих пацієнтів, так і в амбулаторних умовах [26,27,28]. Зокрема Kaliyaperumal et al [28] порівнювали показники ВСР у пацієнтів з COVID-19 з такими у здорових осіб.…”

Section: таблицяunclassified

The Impact of COVID-19 upon Intracardiac Hemodynamics and Heart Rate Variability in Stable Coronary Artery Disease Patients

Netyazhenko

Mostovyi

Safonova

2023

ujcvs

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The aim. To study the impact of COVID-19 upon intracardiac hemodynamics and heart rate variability (HRV) in stable coronary artery disease (SCAD) patients. Materials and methods. In this cross-sectional study we analyzed clinical and instrumental data obtained from a sample of 80 patients. The patients were divided into three groups: group 1 included patients with SCAD without COVID-19 (n=30), group 2 included patients with SCAD and COVID-19 (n=25), and group 3 included patients with COVID-19 without SCAD (n=25). The control group included 30 relatively healthy volunteers. Results. The changes in intracardiac hemodynamics and HRV in group 2 were characterized by the impaired left ventricular systolic and diastolic function, dilation of both ventricles and elevated systolic pulmonary artery pressure. Left ventricular end-diastolic volume was higher in group 2 (205±21 ml) than that in group 1 (176±33 ml; р<0.001) and group 3 (130±21 ml; р<0.001). Patients in the groups 1–3, compared to controls, presented with the decrease in the overall HRV (by standard deviation [SD] of all NN intervals [SDNN]; SD of the averages of NN intervals in all 5 min segments of the entire recording; and mean of the SDs of all NN intervals for all 5 min segments of the entire recording) and parasympathetic activity (root-mean-square difference of successive NN intervals; the proportion derived by dividing the number of interval differences of successive NN intervals greater than 50 ms [NN50] by the total number of NN intervals [pNN50], and high frequency spectral component), along with QT interval prolongation and increase in its variability. Group 2 demonstrated the most advanced changes in HRV (by SDNN and pNN50) and both QT interval characteristics. Conclusions. The patients with SCAD and concomitant COVID-19, along with both ventricles dilation and intracardiac hemodynamics impairment, presented with the sings of autonomic dysfunction, QT interval prolongation and increase in its variability. The heart rate variability and QT interval characteristics should be additionally considered in the management of such patients.

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“…HRV has been shown to be useful in the detection and evaluation of palpitations in patients with benign paroxysmal positional vertigo and fibromyalgia (11,12). However, there is limited research on the correlation between HRV and palpitations in individuals with long COVID (13). This study aims to analyze the relationship between palpitation symptoms and HRV parameters in female patients with long COVID to gain a better understanding of the autonomic mechanism behind these symptoms.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the correlation between heart rate variability and palpitation symptoms in female patients with long COVID

Jiang,

Cheng,

Xiao

et al. 2023

Front. Cardiovasc. Med.

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ObjectivesTo analyze the correlation between heart rate variability (HRV) and palpitation symptoms in female patients with long COVID.MethodsA total of 272 female healthcare workers who were infected with SARS-CoV-2 for the first time in December 2022 at Fuzhou First Hospital affiliated with Fujian Medical University, were selected as study subjects. These subjects were divided into three groups based on their symptoms: a group with palpitations (70 cases), a group without palpitations but with other symptoms (124 cases), and a group consisting of asymptomatic cases (78 cases). The study compared the general information, COMPASS-31 scores, quality of life scores, and HRV parameters among the three groups. Furthermore, it analyzed the factors influencing palpitation symptoms in female patients with long COVID.ResultsCompared to the other two groups, the HRV parameters SDNN, HRVIndex, LF, and TP were significantly reduced in the group with palpitations (p < 0.05). Multivariate analysis revealed that HRVIndex (p = 0.016; OR: 0.966, 95% CI: 0.940∼0.994) had a significant impact on palpitation symptoms in female patients with long COVID.ConclusionsThe symptoms of palpitations in female patients with long COVID were found to be related to HRV parameters. Autonomic dysfunction may be connected to the occurrence of palpitation symptoms in long COVID.

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The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups

Cited by 6 publications

References 69 publications

Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

The Impact of COVID-19 upon Intracardiac Hemodynamics and Heart Rate Variability in Stable Coronary Artery Disease Patients

Analysis of the correlation between heart rate variability and palpitation symptoms in female patients with long COVID

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