The impact of semen quality, occupational exposure to environmental factors and lifestyle on recurrent pregnancy loss

Wang, Ruixue; Zhou, Hongli; Zhang, Zhihong; Rulin, Dai; Geng, Dongfeng; Liu, Ruizhi

doi:10.1007/s10815-013-0091-1

Cited by 48 publications

(27 citation statements)

References 23 publications

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“…Comparing the distribution of AB aniline blue stained sperm (Table 1, Figure 1C) of RPL patients with that of the control group, it was found that the percentage of intermediate stained spermatozoa had significantly increased along with a significant decrease in the percentage of normal protamine packaged spermatozoa (light stain). About three studies have been undertaken to measure aberrant sperm chromatin packaging by AB staining in RPL patients [Kazerooni et al 2009;Ruixue et al 2013;Zidi-Jrah et al 2016]. Our results are congruent with those obtained by these three works, which verified a lower rate of spermatozoa with normal nuclear chromatin condensation from men with spontaneous recurrent abortion compared with the control group.…”

Section: Resultssupporting

confidence: 89%

Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss

Mohanty

Swain

Goswami

et al. 2016

Systems Biology in Reproductive Medicine

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Contribution from a defective paternal genome has been attributed to be an important cause for spontaneous recurrent pregnancy loss (RPL). Increased oxidative stress results in decreased detoxification and is a cause for damage to chromatin, proteins, and membrane lipids. The present study aimed to explore if there is a significant relationship between retained histones due to defective packaging of DNA in spermatozoa and oxidative stress. RPL patients (n=16) with a history of ≥2 embryo losses before the 20th week of gestation and no female factor abnormality, and fertile healthy volunteers (n=20) as controls were included in the study. A significant difference in the levels of protein carbonylation and lipid peroxidation together with an increased retention of histones in the experimental groups was noticed. Histone carrying sites for oxidative modification such as arginine and lysine might be responsible for disturbing the paternal epigenomic control during early stages of embryonic differentiation leading to abortion. ARTICLE HISTORY

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Section: Resultssupporting

confidence: 89%

Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss

Mohanty

Swain

Goswami

et al. 2016

Systems Biology in Reproductive Medicine

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“…Semen parameters, such as sperm concentration, motility, viability, and morphology provide useful insight into the semen quality. However, the role and the correct interpretation of these semen parameters remain unclear and their implications on recurrent pregnancy loss are debatable ( Ruixue et al ., 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Seminal profile of 23,504 patients over the years: 7 years of experience

Nogueira

Yoshida

Vilariño

et al. 2018

JBRA Assisted Reproduction

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ObjectiveTo evaluate the behavior of seminal parameters over the years - 2010 to May 2017.MethodsA retrospective study, carried out from January 2010 to May 2017, covering men who underwent sperm examination. Seminal parameters (volume, sperm concentration, motility, morphology, age and duration of infertility in years) of 23,504 men were evaluated. The groups were compared to each other to check whether there were changes to the seminal parameters in that period.ResultsThere was no change over the years considering the time of infertility, in an average of 3.78 years. The mean age of the patients was 36.53 years, with a trend of increase in 0.2 years. In relation to the volume of semen samples, the mean value was 3.29mL, with a decrease trend in 0.05mL. As for sperm concentration, the average was 34.37 million/mL, with a decrease trend of 1.0 million/mL. Progressive sperm motility showed an average of 47.27% and there was a decrease trend of 0.67%. Finally, sperm morphology presented an average of 2.79% of normal spermatozoa, with a decrease trend of 0.33%.ConclusionIt can be noted that over the years, the sperm quality of men looking for assisted reproduction clinics has tended to decrease in macroscopic and microscopic parameters (volume, sperm concentration, motility and morphology).

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“…There are many factors which effect semen parameters such as environmental issues, tight under garments which raises the local temperature, life-styles, occupational hazards and sleep deprivation adversely effect semen parameters. [ 1 2 3 4 ] Added to these smoking, which causes harmful effects to probably every tissue of the human body[ 5 ] effects semen parameters as well. There is conflicting findings on the effect of smoking on the quality of semen.…”

Section: Introductionmentioning

confidence: 99%

Effect of smoking on reproductive hormones and semen parameters of infertile Saudi Arabians

Al-Turki

2015

Urol Ann

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Objective:The purpose of this retrospective study is to look into the effect of smoking on semen and hormonal profile of Saudi Arabians attending infertility clinics.Materials and Methods:Medical record numbers of patients who attended infertility clinics and who underwent full assessment were identified rom Quadramed system and out-patient log books between January 2010 and December 2012. The standard protocol of the patients include full history, age, number of years of marriage personal habits of smoking, alcohol consumption, primary or secondary infertility. Standard laboratory tests which were performed, included, complete blood picture, random blood sugar, testosterone, follicle stimulation hormone, luteinizing hormone, prolactin level and semen analysis; volume, count, progressive motility and morphology. The data was entered in the database and analyzed.Results:During the study period, 279 patients attended and infertility clinic and only 258 gave the sample for analysis. The average age of patients in the smoking group was 34.23 ± 7.66 and in the nonsmokers 34.07 ± 7.92 years. Primary infertility was more common in smokers versus nonsmokers P < 0.001 confidence interval (CI)< −44.0705, total serum testosterone level was lower 383.8 ± 239.5 versus 422.5 ± 139.2 ng/dL (0.009 CI< −9.9415), serum prolactin level was higher 18.68 ± 13.28 versus 12.85 ± 12.34 ng/mL (0.001 CI < 8.3794). The average volume of the semen among the smokers was 2.8 ± 1.35 mL and in nonsmokers it was 3.08 ± 0.76 mL (P < 0.008 CI< −0.123). The mean progressive motility in smokers was 31.5 ± 23.1 compared to nonsmokers 40.05 ± 25.43% (0.002 CI< −3.2962) and total sperm count was 119.52 ± 114.12 and 139.71 ± 104.82 million/mL (0.07 CI < 1.4657).Conclusions:This study shows that the effect of smoking is dramatic reduction in the hormonal levels and semen parameters. It is recommended that smoking men undergoing fertility treatment should stop smoking to increase their chances of having offspring.

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The impact of semen quality, occupational exposure to environmental factors and lifestyle on recurrent pregnancy loss

Cited by 48 publications

References 23 publications

Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss

Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss

Seminal profile of 23,504 patients over the years: 7 years of experience

Effect of smoking on reproductive hormones and semen parameters of infertile Saudi Arabians

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