The impact of serum uric acid level on arterial stiffness and carotid atherosclerosis: The Korean Multi-Rural Communities Cohort study

Bae, Ji Suk; Shin, Dong Hoon; Park, Pil Sook; Choi, Bo Youl; Kim, Mi Kyung; Shin, Min‐Ho; Lee, Younghoon; Chun, Byung-Yeol; Kim, Seong-Kyu

doi:10.1016/j.atherosclerosis.2013.08.017

Cited by 51 publications

(58 citation statements)

References 38 publications

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“…In 2012, Lin et al 16 reported that SUA is associated with arterial stiffness-measured by brachial-ankle pulse wave velocity-in more than 5000 participants of the Fujian Province in South China. One year later, Bae et al 17 confirmed these results in 5568 participants of the Korean Multi-Rural Communities Cohort. Taken together, these studies indicate that SUA might have an effect on aberrant changes of vascular properties.…”

Section: Introductionsupporting

confidence: 55%

The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

Mayer

Mannhalter

Minar

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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Section: Introductionsupporting

confidence: 55%

The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

Mayer

Mannhalter

Minar

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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“…The Atherosclerosis Risk in Communities (ARIC) Study also found a correlation between the uric acid level and an elevated CIMT in men; however, that correlation was not independent of the use of diuretics 34) . In contrast, no association between the serum uric acid level and carotid atherosclerosis was observed in the Korean Multi-Rural Communities Cohort study or a cohort of hypertensive women 35,36) ; these study participants were restricted to specific populations of rural areas or females patients with hypertension. Hence, data for the general population are scare, especially in Chinese populations.…”

Section: Resultsmentioning

confidence: 99%

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

Chen

Sun

et al. 2015

JAT

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Aim:The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease. Considering that the independent association between the serum uric acid level and CIMT remains controversial due to the complex interrelationship with other known cardiovascular risk factors, further studies are needed. The aim of the present study is to explore the association between the serum uric acid level and CIMT in a general Chinese population and determine whether the association differs according to varied metabolic status. Methods: The present study was cross-sectional in design. A total of 10,281 community-based participants 40 years of age or older from Shanghai, China were included in the current analysis. All participants underwent a detailed questionnaire interview, anthropometric measurements and ultrasonography to assess the CIMT. Blood and urine samples were collected for the biochemical measurements. Results: The serum uric acid levels were positively associated with obesity-and diabetes-related parameters and the CIMT. In a logistic regression model controlling for potential confounders, compared with the participants in the first quartile of the uric acid level, those in the fourth quartile had a higher odds of an elevated CIMT in both men (odds ratio [OR] 1.37; 95% confidence interval [CI] 1.07-1.75) and women (OR 1.48; 95% CI 1.12-1.94). The subgroup analyses revealed that an association between an elevated CIMT and the serum uric acid level persisted regardless of diuretic use and the hypertension, diabetes mellitus and chronic kidney disease status. However, the association disappeared in the patients who consumed alcohol and in premenopausal women. Conclusions: The serum uric acid level is positively associated with an elevated CIMT in middleaged and elderly Chinese subjects, independent of known risk determinants of cardiovascular disease. J Atheroscler Thromb, 2015; 22: 823-832.

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“…Fang et al (2014) reported that uric acid levels were associated with the risk of arterial stiffness using peripheral PWV. Several other studies have also reported the association of uric acid with arterial stiffness (Saijo et al, 2005;Bae et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

“…Relationships between arterial stiffness and uric acid have been widely analyzed over the past several years, with conflicting results (Chen et al, 2010;Lim et al, 2010;Fang et al, 2014;Saijo et al, 2005;Bae et al, 2013). Fang et al (2014) reported that uric acid levels were associated with the risk of arterial stiffness using peripheral PWV.…”

Section: Discussionmentioning

confidence: 99%

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Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

Sull

Koh

Cho

et al. 2017

BSL

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Measuring the pulse wave velocity (PWV) is a non-invasive method for evaluating the stiffness of the vessel wall. While previous studies investigated the association of uric acid level with arterial stiffness, most did not consider smoking status and obesity as covariates. The objective of this study was to investigate the relationship between uric acid levels and arterial stiffness, considering smoking status and obesity. We studied 3390 subjects (1940 males and 1450 females). Abnormal PWV was also defined as the highest quartile of values in the subjects. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Approximately 41.9% of men and 3.7% of women were current smokers. Prevalence of hypertension was 11.4% in men and 7.0% in women. In women, hyperuricemia was associated with abnormal PWV (OR 1.58; 95% CI 1.03~2.43). Hyperuricemia was also associated with abnormal PWV (OR 2.37; 95% CI 1.01~5.59) in non-or light male smokers with normal blood pressure. This study suggests that uric acid is associated with arterial stiffness in women and non-smoking men.

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The impact of serum uric acid level on arterial stiffness and carotid atherosclerosis: The Korean Multi-Rural Communities Cohort study

Cited by 51 publications

References 38 publications

The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

The Impact of Uric Acid on Long-term Mortality in Patients with Asymptomatic Carotid Atherosclerotic Disease

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

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