The Impact of Severe COVID–19 on Corneal Endothelial Cells–Analysis of the In Vivo Noncontact Specular Microscopy

Bayram, Nurettin; Özsaygılı, Cemal; Gündoğan, Medine; Ünal, Sefa; Bagci, Fatma; Pangal, Emine; Yuvacı, İsa

doi:10.1080/09273948.2023.2219312

Ocular Immunology and Inflammation

2023

DOI: 10.1080/09273948.2023.2219312

|View full text |Cite

The Impact of Severe COVID–19 on Corneal Endothelial Cells–Analysis of the In Vivo Noncontact Specular Microscopy

Nurettin Bayram

Cemal Özsaygılı

Medine Gündoğan

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms

Kılıçarslan,

Yılmaz Çebi,

Doğan

et al. 2024

Cornea

View full text Add to dashboard Cite

Purpose: This study aimed to investigate the long-term effects of COVID-19 on corneal endothelial cell morphology in patients with ocular symptoms to assess possible corneal involvement in patients who recovered. Methods: The COVID-19 group included patients diagnosed and treated at Istanbul University Cerrahpasa Medical Faculty with confirmed SARS-CoV-2 infection and ocular irritation symptoms. The control group was comprised of age- and sex-matched individuals. The controls had no ocular pathologies. Noncontact specular microscopy (Konan Cell Check SL, Hyogo, Japan) was performed using the center method after 156 ± 16 days of COVID-19 diagnosis. Parameters such as endothelial cell density (ECD), hexagonality (HEX), coefficient of variation, and central corneal thickness were analyzed. Results: Specular microscopy results of 54 COVID-19 patients with ocular irritation symptoms and 72 controls were evaluated. Ocular symptoms in COVID-19 patients included conjunctival hyperemia, foreign body sensation, tearing, ocular secretion, and chemosis. Mean (±SD) ECD was 2770 ± 31 (cells/mm2) in the COVID-19 group and 2897 ± 26 in the control group, and mean (±SD) HEX was 46.52 ± 6.38 in the COVID-19 group and 58.22 ± 13.94 in the control group. COVID-19 patients exhibited significantly lower endothelial ECD and HEX levels than controls (P = 0.003 and P < 0.001, respectively). Coefficient of variation and central corneal thickness analyses did not reach statistical significance. Conclusions: COVID-19 can cause long-term alterations in the corneal endothelial cells, leading to decreased ECD and HEX. Future research should focus on the long-term implications of COVID-19 on the corneal health and visual outcomes.

show abstract

Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms

Kılıçarslan,

Yılmaz Çebi,

Doğan

et al. 2024

Cornea

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Impact of Severe COVID–19 on Corneal Endothelial Cells–Analysis of the In Vivo Noncontact Specular Microscopy

Cited by 1 publication

References 30 publications

Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms

Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms

Contact Info

Product

Resources

About