The impact of severity of hypertension on association of PGC-1αGene with blood pressure and risk of hypertension

Xie, Gaoqiang; Guo, Dongshuang; Liu, Ying; Liang, Shengying; Wu, Yangfeng

doi:10.1186/1471-2261-7-33

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Chen et al found that +1302G>A and Gly482Ser polymorphisms of PGC-1α do not play roles in the pathogenesis of hypertension in Chinese (Chen et al, 2004). Xie et al reported that Gly482Ser and +2962A/G polymorphisms of PGC-1α are associated with severe hypertension (Xie et al, 2007), which is consistent with the results of Oberkofler et al (2003) and indicates that severe hypertension may be correlated to genetic background. All these controversial results may be due to differences in race, aims, sample size, observed variables, methods, and environmental factors.…”

Section: Discussionsupporting

confidence: 61%

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

Su¹,

Dong²,

Yan³

et al. 2011

Genet. Mol. Res.

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We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose were measured, and body mass index was calculated. PCR-RFLP was used to analyze Gly482Ser polymorphisms. There were significant differences in triglycerides, fasting plasma glucose, and body mass index between hypertension patients and healthy controls. Cholesterol levels did not differ significantly. The PGC-1α gene GG, GA and AA genotype distributions were 37.2, 48.5 and 14.4%, respectively, in patients and 48.6, 37.3 and 14.1% in healthy controls. The frequencies of PGC-1α genotype GA and allele A were significantly different between hypertension patients and healthy Mongolians. We concluded that PGC-1α Gly482Ser polymorphism is associated with hypertension in Mongolians in Inner Mongolia.

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Section: Discussionsupporting

confidence: 61%

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

Su¹,

Dong²,

Yan³

et al. 2011

Genet. Mol. Res.

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“…PPARGC1A interacts with peroxisome proliferators-activated receptors (PPARs) and has various functions, including as integrator of the molecular regulatory circuitry involved in the transcriptional control of cellular energy metabolism, including mitochondrial function and biogenesis [ 27 , 28 ], and regulation of gene expression involved in lipid and glucose metabolism. The PPARGC1A Gly482Ser polymorphism is also associated with obesity, hypertension, and diabetes [ 14 - 18 , 29 ]. NAFLD is often accompanied by obesity, hypertriglyceridemia, type 2 diabetes, and insulin resistance [ 30 ], and PPARGC1A knockout mice develop hepatic steatosis [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) are useful tools in the search for genetic factors responsible for disease and are being intensively investigated in various common diseases, such as obesity, diabetes, and hypertension. Expression of PPARGC1A has been reported to be associated with metabolic factors, such as type 2 diabetes, hypertension, obesity [ 13 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

et al. 2008

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“…The following studies suggest a link between PGC-1α and atherogenesis at the clinical level: Xie et al reported a correlation between PGC-1α polymorphism and hypertension [14] , and Zhang et al showed an association between PGC-1α polymorphism and the prevalence of coronary artery disease [15] .…”

Section: Introductionmentioning

confidence: 99%

ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis

et al. 2010

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BackgroundAtherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs). In the last years many molecules with crucial metabolic functions have been shown to prevent important steps in the progression of atherogenesis, including peroxisome proliferator activated receptors (PPARs) and the class III histone deacetylase (HDAC) SIRT1. The PPARγ coactivator 1 alpha (Ppargc1a or PGC-1α) was identified as an important transcriptional cofactor of PPARγ and is activated by SIRT1. The aim of this study was to analyze total PGC-1α deficiency in an atherosclerotic mouse model.Methodology/Principal FindingsTo investigate if total PGC-1α deficiency affects atherosclerosis, we compared ApoE−/− PGC-1α−/− and ApoE−/− PGC-1α+/+ mice kept on a high cholesterol diet. Despite having more macrophages and a higher ICAM-1 expression in plaques, ApoE−/− PGC-1α−/− did not display more or larger atherosclerotic plaques than their ApoE−/− PGC-1α+/+ littermates. In line with the previously published phenotype of PGC-1α−/− mice, ApoE−/− PGC-1α−/− mice had marked reduced body, liver and epididymal white adipose tissue (WAT) weight. VLDL/LDL-cholesterol and triglyceride contents were also reduced. Aortic expression of PPARα and PPARγ, two crucial regulators for adipocyte differentitation and glucose and lipid metabolism, as well as the expression of some PPAR target genes was significantly reduced in ApoE−/− PGC-1α−/− mice. Importantly, the epididymal WAT and aortic expression of IL-18 and IL-18 plasma levels, a pro-atherosclerotic cytokine, was markedly reduced in ApoE−/− PGC-1α−/− mice.Conclusions/Significance ApoE−/− PGC-1α−/− mice, similar as PGC-1α−/− mice exhibit markedly reduced total body and visceral fat weight. Since inflammation of visceral fat is a crucial trigger of atherogenesis, decreased visceral fat in PGC-1α-deficient mice may explain why these mice do not develop enhanced atherosclerosis.

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The impact of severity of hypertension on association of PGC-1αGene with blood pressure and risk of hypertension

Abstract: Background: Little is known about the impact of severity of hypertension on the association of genes with high blood pressure, which may cause the inconsistently reported associations of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) gene with blood pressure.

Cited by 8 publications

References 17 publications

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis

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