The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review

Leso, Veruscka; Vetrani, Ilaria; Sicignano, Alessandra; Romano, Rosaria; Iavicoli, Ivo

doi:10.3390/ijerph17051527

Cited by 31 publications

(33 citation statements)

References 44 publications

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“…In fact, sleep seems to exert an inhibitory effect on nocturnal TSH secretion: patients subjected to sleep deprivation do not show a significant decrease in TSH concentrations [ 30 , 35 , 36 ]. The inhibiting effect of sleep on TSH secretion has further been confirmed by the finding of increased nocturnal TSH levels in patients who carry out night-shift work [ 38 ] ( Figure 4 ).…”

Section: Chronobiology and Hypothalamic–pituitary–thyroid Axismentioning

confidence: 75%

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Bellastella

Maiorino

Scappaticcio

et al. 2021

Life

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Chronobiology is the scientific discipline which considers biological phenomena in relation to time, which assumes itself biological identity. Many physiological processes are cyclically regulated by intrinsic clocks and many pathological events show a circadian time-related occurrence. Even the pituitary–thyroid axis is under the control of a central clock, and the hormones of the pituitary–thyroid axis exhibit circadian, ultradian and circannual rhythmicity. This review, after describing briefly the essential principles of chronobiology, will be focused on the results of personal experiences and of other studies on this issue, paying particular attention to those regarding the thyroid implications, appearing in the literature as reviews, metanalyses, original and observational studies until 28 February 2021 and acquired from two databases (Scopus and PubMed). The first input to biological rhythms is given by a central clock located in the suprachiasmatic nucleus (SCN), which dictates the timing from its hypothalamic site to satellite clocks that contribute in a hierarchical way to regulate the physiological rhythmicity. Disruption of the rhythmic organization can favor the onset of important disorders, including thyroid diseases. Several studies on the interrelationship between thyroid function and circadian rhythmicity demonstrated that thyroid dysfunctions may affect negatively circadian organization, disrupting TSH rhythm. Conversely, alterations of clock machinery may cause important perturbations at the cellular level, which may favor thyroid dysfunctions and also cancer.

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Section: Chronobiology and Hypothalamic–pituitary–thyroid Axismentioning

confidence: 75%

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Bellastella

Maiorino

Scappaticcio

et al. 2021

Life

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“…A higher prevalence of hyperthyrotropinemia and more adverse effects of hyperthyrotropinemia on lipid metabolism in females than in males were reported [38]. Furthermore, serum thyroid-stimulating hormone (TSH) levels were reported to be signi cantly higher in night-shift workers than in day-shift workers, suggesting an association between serum TSH levels and work style [39]. The relationship between sleep duration and abnormal lipid metabolism in females needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in the Association between Sleep Duration and Cardiometabolic Risk: A Cross-sectional Study

Matsuo

Tani

Matsumoto

et al. 2020

Preprint

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Background: Inappropriate sleep duration (shorter/longer than optimal sleep duration) has come to be identified as a potential cardiometabolic risk factor, and thereby, as a risk factor for atherosclerotic cardiovascular disease (ASCVD). Few data exist regarding the gender differences in the relationship between sleep duration and cardiometabolic risk.Methods: This cross-sectional study was conducted in a study population of 9262 apparently healthy (5004 male, 4258 female) subjects at the Health Planning Center of Nihon University Hospital between September, 2015, and October 2016.Results: In the male subjects, as compared to a sleep duration of 6 to 7 hours, a sleep duration of ³8 hours was associated with an odds ratio (OR) for abdominal obesity (defined according to the Japanese criteria for metabolic syndrome as a waist circumference of ³85 cm) of 1.31 (95% confidence interval [CI], 1.004-1.71) and for a non-high-density lipoprotein cholesterol level of ³150 mg/dL (defined as “Borderline hyper” by the Japan Atherosclerosis Society Guidelines for Prevention of ASCVD 2017) of 1.33 (1.05-1.68), and a sleep duration of <5 hours was associated with an OR (95% CI) for a fasting blood glucose of ³100 mg/dL (defined as “high” by a specialized lifestyle checkup program for the detection of symptoms of metabolic syndrome in Japan) of 1.74 (1.25-2.42). On the other hand, in the female subjects, as compared to a sleep duration of 6 to 7 hours, a sleep duration of <5 hours was associated with an OR (95% CI) for abdominal obesity (waist circumference ³90 cm) of 1.98 (1.11-3.55) and for a hemoglobin A1c (HbA1c) level of ³5.6 % of 1.52 (1.10-2.10), whereas a sleep duration of ³8 hours was not associated with worsening of any of the examined cardiometabolic risk factors. Conclusions: There may be gender differences in the relationship between sleep duration and cardiometabolic risk. To further reduce the risk of ASCVD, it may be of particular importance to emphasize adequate sleep duration.Clinical Trial Registration: UMIN (http://www.umin.ac.jp/) Study ID:　 UMIN000037643 retrospectively registered on 9 August 2019

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“…These include evening shift, night shift, graveyard shift, rotational shift, etc. (Costa 2003;Leso et al 2020;Rosa and Colligan 1997;Straif et al 2007). More than one of five shift workers suffered from insomnia (Drake et al 2004;Pepin et al 2018), and one of ten suffered from shift work sleep disorder (Drake et al 2004).…”

Section: Shift Workmentioning

confidence: 99%

“…We defined shift work as "work beyond regular working daytime hours", including evening shift, night shift, fixed shift, on-call shift or rotating shift (Costa 2003;Leso et al 2020;Rosa and Colligan 1997;Straif et al 2007).…”

Section: Shift Workmentioning

confidence: 99%

The association between shift work and possible obstructive sleep apnea: a systematic review and meta-analysis

Yang

Lee

Watanabe

et al. 2021

Int Arch Occup Environ Health

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Background Shift work is a workschedule, since industrial era and some employees work in shift. It causes a desynchronization of the biological clock with consequences on sleep amount and quality, such as insomnia and easy fatigue. Obstructive sleep apnea (OSA) is one of the sleep problems that are getting more and more attention, but studies on the association between shift work and OSA were rare. Herein, we aimed to conduct a systematic review and meta-analysis to investigate the association between shift work and possible OSA. Methods This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We queried PubMed, Embase, and Web of Science databases using a related set of keywords. The inclusion criteria were as follows: (1) participants were adult employees hired by a company or organization; (2) exposure was shift work; and (3) outcome was possible OSA according to examination or assessment. Results We included six studies in the systematic review and five studies were selected for further meta-analysis. A random-effects model showed an association of shift work with a small, non-significant increase in possible OSA cases (pooled prevalence relative risk = 1.05; 95% CI 0.85–1.30; p = 0.65). This association occurred in both healthcare and non-healthcare workers group. Conclusion The association between shift work and possible OSA remains inconclusive and could be small if not negligible. Future studies should assess the association between specific work schedules and specific OSA definitions. Trial registration number PROSPERO ID: CRD42020156837

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The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review

Cited by 31 publications

References 44 publications

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Gender Differences in the Association between Sleep Duration and Cardiometabolic Risk: A Cross-sectional Study

The association between shift work and possible obstructive sleep apnea: a systematic review and meta-analysis

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