The impact of side-effects of antipsychotic agents on life satisfaction of schizophrenia patients: a naturalistic study

Ritsner, Michael S.; Ponizovsky, Alexander M.; Endicott, Jean; Nechamkin, Yakov; Rauchverger, Boris; Silver, Henry; Modai, Ilan

doi:10.1016/s0924-977x(01)00128-6

Cited by 97 publications

(80 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noncompliance is also caused by the fact that schizophrenic patients are a heterogeneous group with different longterm courses [68][69][70][71][72][73]. Another important reason is that on the one hand, the effects of neuroleptic treatment often improve illness symptoms, but on the other hand, the side effects of neuroleptics, especially the EPS, often simultaneously decrease the quality of patients' lives [11,36]. Consequently, EPS and negative symptoms often lead to disruption of medication.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Flupenthixol versus Risperidone: Subjective Quality of Life as an Important Factor for Compliance in Chronic Schizophrenic Patients

et al. 2003

View full text Add to dashboard Cite

Objective: The primary aim of this paper was to compare the effects of flupenthixol and risperidone on subjective quality of life and attitude towards medication in chronic schizophrenic patients with mainly negative symptoms. In a spectrum ranging from its typical end ‘haloperidol’ to its atypical end ‘clozapine’, flupenthixol has typical and atypical characteristics. Methods: The effects of flupenthixol versus risperidone were investigated in a multicenter, double-blind trial, whereas subjective quality of life was assessed by means of the EuroQuol-Visual Analogue Scale and the patient satisfaction questionnaire. The attitude towards medication was assessed by means of the Drug Attitude Inventory-30 (DAI-30). Results: Mean daily dose of study medication was 6.6 (SD 2.9) mg/day flupenthixol and 3.6 (SD 1.2) mg/day risperidone. Both groups showed a significant improvement regarding subjective quality of life and positive attitude towards medication. Especially the categories ‘control of their thoughts’, concentration and ‘feeling better in general’ ameliorated in both groups. In the flupenthixol group, the ‘ability to cope with stress’, ‘feel more relaxed’ and the ‘ability to achieve something’ improved significantly more than in the risperidone group. Conclusions: (1) The spectrum of schizophrenia can be treated effectively with different neuroleptic treatments. (2) Flupenthixol especially improves the ability to cope with stress, the ability to achieve something and feeling more relaxed. (3) Subjective quality of life significantly increased with no difference between the groups.

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, not only clinical symptoms, medical effects and side effects have to be considered as responsible factors, but also other factors like psychosocial functioning and premorbid personality characteristics [11].…”

Section: Introductionmentioning

confidence: 99%

Flupenthixol versus Risperidone: Subjective Quality of Life as an Important Factor for Compliance in Chronic Schizophrenic Patients

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Factors known to influence the quality of life of patients with schizophrenia include psychopathological and psychosocial factors, as well as patient's physical and psychological responses to treatment (BengtssonTops and Hansson, 1999;Hofer et al, 2004;Ritsner et al, 2002;Thornicroft et al, 2004). Adverse events that occur during antipsychotic treatment, in particular, are increasingly recognized as having a considerable negative effect on quality of life and wellbeing (Allison et al, 2003;Hofer et al, 2004;Lambert et al, 2004;Olfson et al, 2005;Ritsner et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Relative association of treatment‐emergent adverse events with quality of life of patients with schizophrenia: post hoc analysis from a 3‐year observational study

Adrianzén¹,

Arango-Dávila

Araujo

et al. 2010

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…the superiority of atypical antipsychotics compared with conventional antipsychotics (3-7) and other studies found proof of superiority limited to some domains of quality of life (8)(9)(10), while other studies could not confirm any superiority (11)(12)(13)(14)(15). In most of the studies a great variability of data on quality of life measures was observed (21), and this is obvious in the present study, as well, with the standard deviation of mean scores frequently being higher than the corresponding mean.…”

Section: Discussionmentioning

confidence: 98%

Self-perception of quality of life in patients treated with antipsychotics

Dima¹,

Vasile²,

Rogozae³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

The study was designed as a 12-month prospective observational study of 131 subjects with schizophrenia or related disorders treated with haloperidol, olanzapine, risperidone, quetiapine, or aripiprazole, recruited from consecutive hospitalized patients in a psychiatry department. Results:The mean scores for patients' reported quality of life and its components and for satisfaction with treatment had a favorable evolution, but increases were of reduced magnitude. The differences among treatment groups were not statistically significant, with few exceptions. A great variability of data was found. Conclusion:Studies with a stratified analysis by factors influencing quality of life perceptions in this category of patients might allow the identification of differences, if any, between antipsychotics in this domain.

show abstract

The impact of side-effects of antipsychotic agents on life satisfaction of schizophrenia patients: a naturalistic study

Cited by 97 publications

References 24 publications

Flupenthixol versus Risperidone: Subjective Quality of Life as an Important Factor for Compliance in Chronic Schizophrenic Patients

Flupenthixol versus Risperidone: Subjective Quality of Life as an Important Factor for Compliance in Chronic Schizophrenic Patients

Relative association of treatment‐emergent adverse events with quality of life of patients with schizophrenia: post hoc analysis from a 3‐year observational study

Self-perception of quality of life in patients treated with antipsychotics

Contact Info

Product

Resources

About