The impact of sleep loss on hippocampal function

Prince, Toni-Moi N.; Abel, Ted

doi:10.1101/lm.031674.113

Cited by 107 publications

(63 citation statements)

References 223 publications

(280 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While disruption of sleep is one potential mechanism by which circadian disruptions can impair cognitive processes (for reviews on sleep and learning see [84–86]), in our model it is unlikely that sleep itself played a large role. Support for this idea comes from circadian gene knockout studies where the total amount of sleep was not affected in Per1-Per2 double-knockout mice [87], yet Per1 deletion led to deficits in learning and memory [27,68].…”

Section: Discussionmentioning

confidence: 99%

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

Snider

Dziema

Aten

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

A large body of literature has shown that the disruption of circadian clock timing has profound effects on mood, memory and complex thinking. Central to this time keeping process is the master circadian pacemaker located within the suprachiasmatic nucleus (SCN). Of note, within the central nervous system, clock timing is not exclusive to the SCN, but rather, ancillary oscillatory capacity has been detected in a wide range of cell types and brain regions, including forebrain circuits that underlie complex cognitive processes. These observations raise questions about the hierarchical and functional relationship between the SCN and forebrain oscillators, and, relatedly, about the underlying clock-gated synaptic circuitry that modulates cognition. Here, we utilized a clock knockout strategy in which the essential circadian timing gene Bmal1 was selectively deleted from excitatory forebrain neurons, whilst the SCN clock remained intact, to test the role of forebrain clock timing in learning, memory, anxiety, and behavioral despair. With this model system, we observed numerous effects on hippocampus-dependent measures of cognition. Mice lacking forebrain Bmal1 exhibited deficits in both acquisition and recall on the Barnes maze. Notably, loss of forebrain Bmal1 abrogated time-of-day dependent novel object location memory. However, the loss of Bmal1 did not alter performance on the elevated plus maze, open field assay, and tail suspension test, indicating that this phenotype specifically impairs cognition but not affect. Together, these data suggest that forebrain clock timing plays a critical role in shaping the efficiency of learning and memory retrieval over the circadian day.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

Snider

Dziema

Aten

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…Sleep and waking states were manually scored in 10-second epochs based on the cortical EEG and nuchal EMG. Scoring performance of the automated system was evaluated by the commonly used measure of percent agreement, in which the number of a given state scored by the automated system matching that scored manually is divided by the total number of the state scored manually (Benington et al, 1994; Diba and Buzsáki, 2007; Havekes et al, 2014; Kamphuis et al, 2015; Kempler and Richmond, 2012; Meerlo et al, 2008; O'Callaghan et al, 2007; Paul et al, 2014; Prince et al, 2014; Prince and Abel, 2013; Ruigt et al, 1989; Sanford et al, 2014; Smith and MacNeill, 1994; Witting et al, 1996). In order to analyze differences in sleep architecture between manipulations, the amount of time in each state was analyzed, and percentages were compared across experimental conditions.…”

Section: Methodsmentioning

confidence: 99%

Stress-free automatic sleep deprivation using air puffs

Gross

Vanderheyden

Urpa

et al. 2015

Journal of Neuroscience Methods

View full text Add to dashboard Cite

Background Sleep deprivation via gentle handling is time-consuming and personnel-intensive. New Method We present here an automated sleep deprivation system via air puffs. Implanted EMG and EEG electrodes were used to assess sleep/waking states in six male Sprague-Dawley rats. Blood samples were collected from an implanted intravenous catheter every 4 hours during the 12-hour light cycle on baseline, 8 hours of sleep deprivation via air puffs, and 8 hours of sleep deprivation by gentle handling days. Results The automated system was capable of scoring sleep and waking states as accurately as our offline version (~90% for sleep) and with sufficient speed to trigger a feedback response within an acceptable amount of time (1.76 s). Manual state scoring confirmed normal sleep on the baseline day and sleep deprivation on the two manipulation days (68% decrease in non-REM, 63% decrease in REM, and 74% increase in waking). No significant differences in levels of ACTH and corticosterone (stress hormones indicative of HPA axis activity) were found at any time point between baseline sleep and sleep deprivation via air puffs. Comparison with Existing Method There were no significant differences in ACTH or corticosterone concentrations between sleep deprivation by air puffs and gentle handling over the 8-hour period. Conclusions Our system accurately detects sleep and delivers air puffs to acutely deprive rats of sleep with sufficient temporal resolution during the critical 4-5 h post learning sleep-dependent memory consolidation period. The system is stress-free and a viable alternative to existing sleep deprivation techniques.

show abstract

“…Sleep deprivation also impaired the recall of the hippocampal-dependent social transmission of food preference task (Wooden et al, 2014). Additionally, deficits in hippocampal plasticity have been noted following the disruption of sleep (Davis, Harding, & Wright, 2003; McDermott et al, 2003; Prince et al, 2014; Tartar et al, 2006) and have been extensively reviewed by others (Kreutzmann et al, 2015; Prince & Abel, 2013). …”

mentioning

confidence: 99%

Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Ward¹,

Wooden²,

Kieltyka³

2017

Psychology & Neuroscience

View full text Add to dashboard Cite

Sleepiness is commonly seen in adolescents and can negatively impact school performance. Little research has investigated the impact of sleepiness in juvenile animals on spatial learning. Sprague-Dawley juvenile (<30 days) and young adult (>60 days) rats were sleep deprived for 24 hours and tested, along with controls, in a water maze task. Sleep deprived juveniles were slower to learn the location of the hidden platform than controls; however, adult performance was not impaired. Sleep deprivation did not impair recall during a probe trial for either age group. Sleep deprivation prior to testing slowed spatial learning in juveniles but not adults.

show abstract

The impact of sleep loss on hippocampal function

Cited by 107 publications

References 223 publications

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

Stress-free automatic sleep deprivation using air puffs

Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Contact Info

Product

Resources

About