2020
DOI: 10.5664/jcsm.8630
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The impact of sleep problems on functional and cognitive outcomes in children with Down syndrome: a review of the literature

Abstract: The aim of this review was to summarize the existing literature on the association between sleep problems and cognition, function, and behavior in children with Down syndrome. Methods: Embase, PubMed, CINAHL, and PsychINFO databases were searched to retrieve all studies published between 1990 and 2018 that evaluated the relationship between sleep and cognition, function, or behavior in children with Down syndrome. Results: Fifteen articles were included, which were mostly of a cohort or case-controlled design.… Show more

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Cited by 17 publications
(8 citation statements)
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“…Because of the prevalence among people with DS, sleep breathing disorders and associated neuropsychological and psychopathological features have been largely investigated; however, less is known about the neuropsychological and psychopathological correlates of other sleep disturbances. As highlighted by a recent review on this topic, the impact of different kinds of sleep disorders in children with DS still requires widely researched and well-designed studies to better characterize such relationships [ 35 ].…”
Section: Introductionmentioning
confidence: 99%
“…Because of the prevalence among people with DS, sleep breathing disorders and associated neuropsychological and psychopathological features have been largely investigated; however, less is known about the neuropsychological and psychopathological correlates of other sleep disturbances. As highlighted by a recent review on this topic, the impact of different kinds of sleep disorders in children with DS still requires widely researched and well-designed studies to better characterize such relationships [ 35 ].…”
Section: Introductionmentioning
confidence: 99%
“…Our work also demonstrates the potential of DYRK1A inhibitors as sleep correctors for DS and AD-DS which may slow pathology and boost cognition, the high throughput capability of flies will allow further characterisation and screening of DS and AD circadian and sleep drugs ( Dissel et al, 2017 ; Wang et al, 2020 ). People with DS also display disrupted sleep including sleep apnoea which can negatively impact their cognition and motor control ( Chawla et al, 2020 ). Likewise, many people with AD in addition to the disrupted sleep at night mentioned previously also display sun-downing, where upon the patient experiences more anxiety and confusion in the evening ( Vitiello et al, 1992 ; McCurry et al, 1999 ; Volicer et al, 2001 ).…”
Section: Discussionmentioning
confidence: 99%
“…This work also validates the use of Drosophila as a high throughput system to screen for novel DS and AD circadian and sleep drugs 61 , 66 . Therefore, DYRK1A inhibitors have potential to be tested as sleep correctors for DS that would likely also have beneficial effects on cognition and motor skills 6 . Likewise, the drugs may also be effective for sleep disruption in AD with the additional potential benefit of correcting sun-downing, when the patients’ symptoms, anxiety and confusion are greater in the evening.…”
Section: Discussionmentioning
confidence: 99%