The impact of smoking on male lower urinary tract symptoms (LUTS)

Kawahara, Takashi; Ito, Hiroki; Uemura, Hiroji

doi:10.1038/s41598-020-77223-7

Cited by 17 publications

(13 citation statements)

References 38 publications

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“…Among the other demographic variable studied in the literature, we did not observe any significant association between POUR and smoking status, BMI or previous surgical history. Although tobacco use was purported to enhance the rate of endothelial sclerosis leading to higher incidence of bladder ischemia and lower urinary tract complications, [26][27][28] such an association was not supported by our meta-analysis. Based on our meta-analysis, three co-morbidities were significantly associated with increased incidence of POUR, namely BPH, DM and CAD.…”

Section: Discussioncontrasting

confidence: 58%

Risk Factors for Postoperative Urinary Retention Following Lumbar Spine Surgery: A Review of Current Literature and Meta-Analysis

Reed

Mihas

Fortin

et al. 2022

Global Spine Journal

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Study Design Systematic Review and Meta-analysis Objective Postoperative urinary retention (POUR) is a common complication following lumbar spine surgery (LSS) and timely recognition is imperative to avoid long-term consequences. The aim of the current meta-analysis was to systematically review the literature in order to identify risk factors associated with POUR after LSS. Methods In accordance with PRISMA guidelines, a systematic review of the literature was performed using Pubmed, EMBASE, and MEDLINE database for articles on POUR following LSS. A meta-analysis was performed comparing patients with and without POUR; and the factors associated with this adverse event were analyzed. The pooled data were reported as mean differences with 95% confidence intervals (CI; P < .05). Heterogeneity among the studies was evaluated using the I2 statistic. Results The meta-analysis included 10 studies compromised of 30,300 patients. Based on our analysis, patients who were male, were older in age, underwent instrumented fusion, had diabetes mellitus, coronary artery disease, or benign prostatic hypertrophy had significantly higher risk of developing POUR. Additionally, patients in who developed POUR had significantly longer surgical times and higher volumes of intra-operative fluid administration, as compared with non-POUR patients. The POUR patients also had a significantly higher association with urinary tract infection. Prior surgery, BMI, length of stay, and smoking status did not reveal any statistical association with POUR. Conclusions Risk factors associated with POUR following LSS include male gender, older age, longer surgical times, fusion procedures, larger volumes of intraoperative infusions, and associated comorbidities like DM, CAD, and BPH.

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Section: Discussioncontrasting

confidence: 58%

Risk Factors for Postoperative Urinary Retention Following Lumbar Spine Surgery: A Review of Current Literature and Meta-Analysis

Reed

Mihas

Fortin

et al. 2022

Global Spine Journal

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“…Prior studies have reported conflicting results for the relationship between smoking and LUTS incidence and progression. Kawahara et al 7 studied Japanese men ( n = 9042) in a cross‐sectional population‐based study using a web‐based questionnaire using several metrics including IPSS. They evaluated the symptoms of 3545 nonsmokers, 3060 ex‐smokers, and 2437 current smokers and reported that current smokers and ex‐smokers had significantly higher IPSS total scores than nonsmokers (mean [SD]: 5.75 ± 7.02, 6.58 ± 6.96, 4.23 ± 6.33, respectively; all comparisons p < 0.0001).…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] Studies reported that compared with nonsmokers, smokers have a higher risk of LUTS, no additional risk and potentially, even a lower risk. [6][7][8][9] Similarly, among men with LUTS, consistent patterns have not been observed for the relationship between smoking and LUTS progression. 8,10 Therefore, while it is well-established that smoking has a multitude of adverse health effects, its effect on the incidence and progression of LUTS and BPH remains unclear.…”

Section: Introductionmentioning

confidence: 93%

“…While a growing body of evidence suggests that obesity, diabetes, physical activity, and diet have the potential to influence LUTS, and some foods may aggravate the condition, the role of tobacco remains less clear 4–6 . Studies reported that compared with nonsmokers, smokers have a higher risk of LUTS, no additional risk and potentially, even a lower risk 6–9 . Similarly, among men with LUTS, consistent patterns have not been observed for the relationship between smoking and LUTS progression 8,10 .…”

Section: Introductionmentioning

confidence: 99%

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Smoking and lower urinary tract symptoms in Reduction by Dutasteride of Prostate Cancer Events Trial

Kramer

Moreira

et al. 2023

The Prostate

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Background Benign prostatic hyperplasia is common in older men, with many developing lower urinary tract symptoms (LUTS) that impair quality of life. Smoking has many well‐established adverse effects, but its effects on benign prostatic hypertrophy (BPH) and associated LUTS are unclear. We sought to determine if smoking is a risk factor for the incidence of LUTS in asymptomatic men and for the progression of LUTS in symptomatic men. Methods We performed a post‐hoc analysis of Reduction by Dutasteride of Prostate Cancer Events in 3060 “asymptomatic” men with baseline International Prostate Symptom Score (IPSS) < 8 and in 2198 symptomatic men with baseline IPSS ≥ 8 not taking 5α‐reductase inhibitors or α‐blockers. We used multivariable Cox regression models to assess associations between smoking status at baseline and LUTS incidence and progression. Among asymptomatic men, incident LUTS was defined as the first report of medical or surgical treatment for BPH, or sustained clinically significant LUTS (two reports of IPSS > 14). Among symptomatic men, LUTS progression was defined as IPSS increase of ≥4 points from baseline, surgical intervention for BPH, or starting a new BPH drug. Results Of 3060 asymptomatic men, 15% (n = 467) were current, 40% (n = 1231) former, and 45% (n = 1362) never‐smokers. Of 2198 symptomatic men, 14% (n = 320) were current, 39% (n = 850) former, and 47% (n = 1028) never‐smokers. In asymptomatic men, compared with never‐smokers, current and former smoking at baseline were not associated with LUTS incidence (adjusted hazard ratio [adj‐HR] = 1.08; 95% confidence interval [95% CI]: 0.78–1.48 and adj‐HR = 1.01; 95% CI: 0.80–1.30). In symptomatic men, compared with never‐smokers, current and former smoking at baseline were not associated with the progression of LUTS (adj‐HR = 1.11; 95% CI: 0.92–1.33 and adj‐HR = 1.03; 95% CI: 0.90–1.18). Conclusions In REDUCE, smoking status was not associated with either incident LUTS in asymptomatic men or progression of LUTS in symptomatic men.

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“…The onset of LUTS could be triggered by several factors, such as diet ( 5 ), exercise ( 6 , 7 ), metabolic syndrome ( 8 - 10 ), environmental temperature ( 11 ), and so on. It has also been shown that LUTS is related to smoking ( 12 ), sedentary habits ( 5 ), urinary retention ( 13 ), etc., all of which are experienced by the young outpatient physicians, particularly those who work long shifts, in tertiary hospitals. In addition, sleep disorders may aggravate the symptoms of LUTS ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between outpatient duration of young outpatient physicians and lower urinary tract symptoms and sexual dysfunction

Song¹,

Chen²,

Gong³

et al. 2022

Transl Androl Urol

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Background In China, physicians aged 30–45 years who work in tertiary hospitals perform most of the clinical duties, especially outpatient services, and the high-intensity, high-pressure workplace may through long-term sedentary affect their health, particularly urinary health. Methods The study, conducted from October 2020 to October 2021, included male physicians in Xiangya Hospital, the Second Xiangya Hospital, and the Third Xiangya Hospital of Central South University (Hunan, China). They were divided into surgeon and non-surgeon groups. We collect the data on age, body mass index (BMI), duration of outpatient duties and the International Prostate Symptom Score-voiding (IPSS-V) and IPSS-storage (IPSS-S), and the IPSS-Total, and the IPSS-Quality of Life Index (IPSS-QOL), and the Athens insomnia scale (AIS), and the International Prostate Symptom Score (IIEF-5). Results The duration of outpatient duties positively correlated with IPSS-Total (P<0.001), IPSS-S (P<0.001), and IPSS-QOL (P<0.001) and negatively correlated with IIEF-5 (p=0.032). Compared to non-surgeons, surgeons performed fewer outpatient duties. The IPSS-Total (P=0.016), IPSS-Storage (P=0.005), and QOL scores (P=0.046) of the non-surgeon group were higher and the IIEF-5 scores were lower (P=0.039). There were no significant differences between the groups regarding age, body mass index, IPSS-Voiding, and Athens insomnia scale scores. A positive correlation between outpatient visit duration and lower urinary tract symptoms (LUTS) in the IPSS-Storage subscale was observed and there was a weak negative correlation between duration of outpatient duties and the IIEF-5 score. Conclusions Compared to surgeons, non-surgeons had more outpatient duties, and they experienced more severe LUTS and sexual dysfunction, which suggests that outpatient duties maybe should not be more than 4 days/week in Chinese tertiary medical centers.

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The impact of smoking on male lower urinary tract symptoms (LUTS)

Cited by 17 publications

References 38 publications

Risk Factors for Postoperative Urinary Retention Following Lumbar Spine Surgery: A Review of Current Literature and Meta-Analysis

Risk Factors for Postoperative Urinary Retention Following Lumbar Spine Surgery: A Review of Current Literature and Meta-Analysis

Smoking and lower urinary tract symptoms in Reduction by Dutasteride of Prostate Cancer Events Trial

Relationship between outpatient duration of young outpatient physicians and lower urinary tract symptoms and sexual dysfunction

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