This article is a summary of the updated version of the review article “The impact of the space experiments on our knowledge of the physics of the Universe” (Giovannelli & Sabau-Graziati 2004: GSG2004) and subsequent slow updating (Giovannelli 2013; Giovannelli & Sabau-Graziati 2012a, 2014a,b, 2015, 2016a,b). We will go along different stages of the evolution of our Universe discussing briefly several examples of results that, in accordance
with our opinion, are the pillars carrying the Bridge between the Big Bang and Biology. A significant part of these results come from great experiments in Earth or from space. Similarly, small experiments on Earth or in space have provided—and will provide—significant results. Due to the limited extension of this work and according to our knowledge, we have made a strict selection of the topics.