Adolescents, when faced with cancer and hospitalization, experience different needs that can have a profound impact on the adolescent and their family. Spirituality and religion are helpful in order to find meaning in the experience of cancer. Therefore, the aim of this study was to explore the spiritual/religious needs of adolescents with cancer in Iran. This study was an exploratory qualitative research. Adolescents with cancer, their families and nurses working in cancer unit formed the participants. The study environment was the cancer unit and the study population was adolescents with cancer in Kerman, Iran. Purposeful sampling and, semi-structured interviews with 14 adolescents with cancer and their families and six nurses were performed individually. To analyze the data, qualitative content analysis was used. From the data analysis four main themes emerged: the need for a relationship with God; the need for a relationship with the self; the need for a relationship with others; and the need for a relationship with the environment and nature. The results of this study provided a new vision in meeting the spiritual/religious needs of adolescents with cancer. According our result, adolescents with cancer, in addition to their developmental stage, need to face the other needs that can come along with the needs of this age period. Regarding these needs, it is helpful to find purpose and meaning in the experience of suffering and pain, and it can prevent spiritual distress.