The impact of splenectomy on human lipid metabolism

Güneş, Örgün; Turgut, Emre; Bağ, Yusuf Murat; Gündoğan, Ersin; Güneş, Ajda; Sümer, Fatih

doi:10.48101/ujms.v127.8500

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…The crucial role in systemic lipid regulation of the spleen was also reported by Alberti et al, who found that splenectomy is associated with changes in lipid metabolism by an elevation of total cholesterol and low-density lipoprotein (LDL) levels while decreasing high-density lipoprotein (HDL) levels [68]. The alteration of LDL cholesterol due to the splenectomy was also observed by other authors [11,12], who linked this operation with the onset of atherosclerosis and other cardiovascular diseases. Wysocki et al observed that in splenectomized patients, triglyceride (TG) levels are significantly higher, while in cases of splenomegaly, total cholesterol (TC) and LDL are notably decreased [69].…”

Section: Discussionsupporting

confidence: 52%

“…It acts as a reservoir for lipids; macrophages store fat through phagocytosis and the spleen exerts the LPL activity. Due to those reasons, splenectomy appeared to have a negative impact on lipid metabolism [11].…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies have revealed the spleen's involvement in diverse functions beyond its classical roles. These include iron metabolism, immune regulation, and an emerging focus on lipid metabolism [11]. Growing evidence suggests that the spleen may influence cancer development and progression through its involvement in systemic lipid metabolism [12].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Lepionka,

Białek,

Czauderna

et al. 2024

Cancers

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The spleen, traditionally associated with blood filtration and immune surveillance, has recently been recognized for its role in systemic lipid metabolism and potential influence on cancer development and progression. This study investigates effects of dietary supplements, specifically conjugated linolenic acids from pomegranate seed oil and bitter melon extract, on the fatty acid (FA) composition of the spleen in the context of cancerous processes. Advanced methods, including gas chromatography–mass spectrometry and silver ion-impregnated high-performance liquid chromatography, were employed to analyze the spleen’s FA profile. Our research uncovered that dietary supplementation leads to alterations in the spleen’s FA profile, especially under the carcinogenic influence of 7,12-dimethylbenz[a]anthracene. These changes did not align with a simple protective or anti-carcinogenic pattern, as previously suggested in in vitro studies. We observed shifts in conjugated FA isomer concentrations and variations in desaturase activities, suggesting disrupted lipid metabolism in cancerous conditions. The findings underscore the spleen’s vital role in lipid metabolism within the body’s systemic health framework, highlighting the complexity of dietary supplements’ impact on FA profiles in the spleen and their potential implications in cancer progression and treatment. This study adds valuable insight into the complex interplay between diet, disease, and metabolic regulation, particularly in cancerous environments.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Lepionka,

Białek,

Czauderna

et al. 2024

Cancers

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“…7 Crude fat originating from BD (i.e., the meadow hay and concentrate). 8 Total crude fat originating from the BD and added oils (i.e., rapeseed oil (R-O) and fish oil (F-O)). 9 Total gross energy of the BD enriched in R-O and F-O without or with antioxidant(s) (i.e., CA, Se as yeast rich in seleno-methionine (Se Ye ) or Se 6 (Se as sodium selenate)).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, a splenic connection with the propagation of certain diseases connected with lipid disorders (like Niemann-Pick’s disease, Gaucher’s disease, Fabry disease or gangliosidoses) was also reported [ 6 ]. Total splenectomy may unfavorably affect levels of plasma lipids (triglycerides, cholesterols, fatty acids (FA)), and lipoproteins [ 7 , 8 ] and thus lead to the development of atherosclerosis and other cardiovascular disorders. The influence of the spleen in lipid metabolism was confirmed in rat, rabbit, and dog models [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Organic and Inorganic Selenium Compounds Affected Lipidomic Profile of Spleen of Lambs Fed with Diets Enriched in Carnosic Acid and Fish Oil

Białek,

Wojtak

et al. 2023

Animals

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The purpose of our study was to investigate the effect of 0.35 mg Se/kg basal diet (BD) (Se as sodium selenate (Se6) and yeast rich in seleno-methionine (SeYe)) and 0.1% carnosic acid (CA) supplementation to the diet containing 1% fish oil (F-O) and 2% rapeseed oil (R-O) on the contents of fatty acids (FA), malondialdehyde (MDA), tocopherols (Ts), and total cholesterol (TCh) in lambs’ spleens. A total of 24 male lambs (4 groups per 6 animals) have been fed: the control diet—the basal diet (BD) enriched in F-O and R-O; the CA diet—BD enriched in F-O, R-O, and CA; the SeYeCA diet—BD enriched in F-O, R-O, CA, and SeYe; the Se6CA diet—BD enriched in F-O, R-O, CA, and Se6. Dietary modifications affected the profiles of saturated (SFA), monounsaturated (MUFA), and polyunsaturated (PUFA) fatty acids in spleens. The SeYeCA and Se6CA diets increased the docosapentaenoic acid preference in Δ4-desaturase; hence, a higher content of docosahexaenoic acid was found in the spleens of SeYe- or Se6-treated lambs than in spleens of animals receiving the CA and control diets. The SeYeCA and Se6CA diets increased the concentration ratio of n-3long-chain PUFA (n-3LPUFA) to FA (n-3LPUFA/FA) in spleens compared to the control and CA diets. The content of n-3PUFA was higher in the spleens of Se6 treated lambs than in spleens of animals receiving the SeYeCA, CA, and control diets. The Se6CA diet increased the content of c9t11CLA in the spleen compared to the control, CA, and SeYeCA diets. Experimental diets reduced the level of atherogenic FA, the content ratios of n-6PUFA/n-3PUFA and n-6LPUFA/n-3LPUFA, and improved the content ratio of MUFA/FA and the value of the hypocholesterolemic/hypercholesterolemic FA ratio in the spleen in comparison with the control diet. The experimental diets supplemented with SeYe or Se6 increased levels of TCh and Ts in spleens in comparison with the CA and control CA diets. The present studies documented that Se6, SeYe, and CA influenced the metabolism of FA, Ts, and cholesterol in spleens.

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What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?

Tarantino,

Citro

2024

Lipids Health Dis

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Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver disease, alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). Although AFLD and NAFLD are similar in their initial morphological features, both conditions involve the same evolutive forms. Moreover, there are various common mechanisms underlying both diseases, including alcoholic liver disease and NAFLD, which are commonalities. In this Review, the authors explore similar downstream signaling events involved in the onset and progression of the two entities but not completely different entities, predominantly focusing on the gut microbiome. Downstream molecular events, such as the roles of sirtuins, cytokeratins, adipokines and others, should be considered. Finally, to complete the feature, some new tendencies in the therapeutic approach are presented.

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The impact of splenectomy on human lipid metabolism

Cited by 4 publications

References 26 publications

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Organic and Inorganic Selenium Compounds Affected Lipidomic Profile of Spleen of Lambs Fed with Diets Enriched in Carnosic Acid and Fish Oil

What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?

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