The Impact of SsPI-1 Deletion on Streptococcus suis Virulence

Zhao, Yan; Li, Gang; Yao, Xinyue; Lu, Shuguang; Wang, Jing; Shen, Xiaodong; Li, Ming

doi:10.3390/pathogens8040287

Cited by 3 publications

(4 citation statements)

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“…Genetic analysis revealed the presence of a unique chromosomal 89 kb pathogenicity island (later renamed SsPI-1) in Chinese epidemic S. suis strains [44,45]. Zhao et al [46] assessed the impact of SsPI-1 deletion on the virulence of S. suis. Swine experimental results showed that elimination of SsPI-1 significantly impairs the pathogenicity of S. suis, suggesting that SsPI-1 plays an important role in bacterial virulence and disease-induced pathology.…”

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confidence: 99%

“…In addition, deletion of SsPI-1 reduced serum levels of TNF-α, IL-6, IL-8, and IL-1β in infected pigs, signifying either a direct role of SsPI-1 in the induction of pro-inflammatory cytokine responses within the host or an indirect effect because of reduced bacteremia. The authors concluded that SsPI-1 is a critical contributor to the evolution of virulence in epidemic S. suis [ 46 ]. Recently, Wang et al [ 47 ] reported 38 sporadic ST7 S. suis strains, which mostly caused sepsis, from patients in the Guangxi Zhuang Autonomous Region between 2007 and 2018.…”

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Streptococcus suis Research: Progress and Challenges

Segura

2020

Pathogens

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Streptococcus suis is considered among the top bacterial pathogens leading to important economic losses to the swine industry, with the incidence of disease increasing as the prophylactic use of antimicrobial is being vanished worldwide. S. suis is also a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Besides, in some Asian countries, it is considered a major public health concern for the general population as well. Antimicrobial resistance is one of the most important global health challenges, and in the absence of preventive measures (such as effective vaccines), S. suis remains a risk for increased antimicrobial resistance and transmission of resistance genes to other bacteria beyond the host animal species. The studies in this Special Issue have evidenced the importance of swine population demographics and management on disease control, progress in molecular tools to better understand the epidemiology of S. suis infections in swine and humans, and the mechanisms involved in different aspects of the immuno-pathogenesis of the disease. The importance of reducing the prophylactic use of antimicrobials in livestock productions and the development of alternative control measures, including vaccination, are herein discussed.

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Streptococcus suis Research: Progress and Challenges

Segura

2020

Pathogens

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“…Zhao et al [168] noted the highest index of variation in the genetic structure of S. suis among bacteria of the genus Streptococcus. Isolates of this species are classified into several dozen serotypes based on the capsular polysaccharide structure (CPS).…”

Section: Streptococcus Suismentioning

confidence: 99%

“…Zhao et al . [168] noted the highest index of variation in the genetic structure of S. suis among bacteria of the genus Streptococcus .…”

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confidence: 99%

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Bacteria of the genus Streptococcus , earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis , S. dysgalactiae , S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining new properties and virulence factors by which they can thrive in new environments. It shows the potential of these bacteria to changes in the genome and the settlement of new hosts. Information is presented on clinical cases that concern streptococcus species belonging to the groups Bovis, Pyogenic and Suis. We also present the antibiotic resistance profiles of these bacteria. The emerging resistance to β-lactams has been reported. In this review, the classification, clinical characteristics and antibiotic resistance of groups and species of streptococci considered as animal pathogens are summarized.

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A critical review on experimental Streptococcus suis infection in pigs with a focus on clinical monitoring and refinement strategies

Liedel,

Rieckmann,

Baums

2023

BMC Vet Res

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Streptococcus suis (S. suis) is a major pig pathogen worldwide with zoonotic potential. Though different research groups have contributed to a better understanding of the pathogenesis of S. suis infections in recent years, there are still numerous neglected research topics requiring animal infection trials. Of note, animal experiments are crucial to develop a cross-protective vaccine which is highly needed in the field. Due to the severe clinical signs associated with S. suis pathologies such as meningitis and arthritis, implementation of refinement is very important to reduce pain and distress of experimentally infected pigs. This review highlights the great diversity of clinical signs and courses of disease after experimental S. suis pig infections. We review clinical read out parameters and refinement strategies in experimental S. suis pig infections published between 2000 and 2021. Currently, substantial differences exist in describing clinical monitoring and humane endpoints. Most of the reviewed studies set the body temperature threshold of fever as high as 40.5°C. Monitoring intervals vary mainly between daily, twice a day and three times a day. Only a few studies apply scoring systems. Published scoring systems are inconsistent in their inclusion of parameters such as body temperature, feeding behavior, and respiratory signs. Locomotion and central nervous system signs are more common clinical scoring parameters in different studies by various research groups. As the heterogenicity in clinical monitoring limits the comparability between studies we hope to initiate a discussion with this review leading to an agreement on clinical read out parameters and monitoring intervals among S. suis research groups.

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The Impact of SsPI-1 Deletion on Streptococcus suis Virulence

Cited by 3 publications

References 34 publications

Streptococcus suis Research: Progress and Challenges

Streptococcus suis Research: Progress and Challenges

Pathogenicity and drug resistance of animal streptococci responsible for human infections

A critical review on experimental Streptococcus suis infection in pigs with a focus on clinical monitoring and refinement strategies

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