The Impact of Suckling and Post-weaning Period on Blood Chemistry of Piglets

Petrovič, Vladimír; Novotný, Jaroslav; Hisira, V.; Link, R.; Leng, Lubomir; Kováč, G.

doi:10.2754/avb200978030365

Cited by 24 publications

(19 citation statements)

References 32 publications

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“…Large amounts of lactose, free and protein-bound amino acids, saturated fatty acids, and unsaturated fatty acids are present in sow's milk (Wu and Knabe, 1994;Mountzouris et al, 1999;van den Borne et al, 2007). After weaning, the piglets ingested complete feed rich in nitrogen compounds with small amounts of fat and carbohydrates (Gu and Li, 2003;Petrovič et al, 2009). The piglets also undergo tremendous changes in intestinal structure and in the ability to absorb nutrients after segregation from the sow (Miller et al, 1986;Gu et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The small intestinal alkaline phosphatase, crucial for fat absorption, has been shown to be reduced in early weaned pigs (Lackeyram et al, 2010). The energy supply of early-weaned pigs is very scant for low feed intake and digestibility (Petrovič et al, 2009). Fat provides much more energy than carbohydrates and protein for the maintenance or growth in the body during weaning (Gu and Li, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Response to weaning and dietary l-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry

Xiao

Hong

et al. 2012

J. Zhejiang Univ. Sci. B

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A novel metabolomic method based on gas chromatography/mass spectrometry (GC-MS) was applied to determine the metabolites in the serum of piglets in response to weaning and dietary L-glutamine (Gln) supplementation. Thirty-six 21-d-old piglets were randomly assigned into three groups. One group continued to suckle from the sows (suckling group), whereas the other two groups were weaned and their diets were supplemented with 1% (w/w) Gln or isonitrogenous L-alanine, respectively, representing Gln group or control group. Serum samples were collected to characterize metabolites after a 7-d treatment. Results showed that twenty metabolites were down-regulated significantly (P<0.05) in control piglets compared with suckling ones. These data demonstrated that early weaning causes a wide range of metabolic changes across arginine and proline metabolism, aminosugar and nucleotide metabolism, galactose metabolism, glycerophospholipid metabolism, biosynthesis of unsaturated fatty acid, and fatty acid metabolism. Dietary Gln supplementation increased the levels of creatinine, D-xylose, 2-hydroxybutyric acid, palmitelaidic acid, and α-L-galactofuranose (P<0.05) in early weaned piglets, and were involved in the arginine and proline metabolism, carbohydrate metabolism, and fatty acid metabolism. A leave-one-out cross-validation of random forest analysis indicated that creatinine was the most important metabolite among the three groups. Notably, the concentration of creatinine in control piglets was decreased (P=0.00001) compared to the suckling piglets, and increased (P=0.0003) in Gln-supplemented piglets. A correlation network for weaned and suckling piglets revealed that early weaning changed the metabolic pathways, leading to the abnormality of carbohydrate metabolism, amino acid metabolism, and lipid metabolism, which could be partially improved by dietary Gln supplementation. These findings provide fresh insight into the complex metabolic changes in response to early weaning and dietary Gln supplementation in piglets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Response to weaning and dietary l-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry

Xiao

Hong

et al. 2012

J. Zhejiang Univ. Sci. B

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“…Generally, weaning causes a wide range of physiological and behavioural responses (Hickey et al, 2003;Loberg et al, 2008;Carroll et al, 2009). After weaning, the concentrations of glutamine, vitamin E and vitamin A in blood were declined (Lauridsen & Jensen, 2005;Dobrowolski & Śliwa, 2008;Petrovič et al, 2009). Therefore, the antioxidant capacity of animals after weaning is generally decreased.…”

Section: The Antioxidant Capacity In Tissuesmentioning

confidence: 99%

Effects of Protein and/or Energy Restriction for Six Weeks, Followed with Nutritional Recovery on the Antioxidant Capacity and Development of Liver, Spleen and Muscle of Weaned Kids

Yang¹,

Sun²,

He³

et al. 2012

JAS

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The effects of protein and/or energy restrictions on the antioxidant capacity and development of liver, spleen and muscle were investigated in kids. Sixty Liuyang Black kids, weaned at 28-day old, were allocated to four treatments: control, either energy or protein restriction, and combined energy and protein restriction. The experimental period consisted of six weeks of nutritional restriction followed with nine weeks of nutritional recovery. On day 42, energy restriction decreased the activity of glutathione peroxidase (GSH-Px) in spleen, the superoxide dismutase (SOD) mRNA level in muscle and spleen, and the ratio of RNA to DNA in liver (P < 0.05); protein restriction decreased the activity of glutathione reductase (GR) in muscle and liver, the ratio of RNA to DNA in liver, and the N concentration and the ratio of N to DNA in spleen and muscle (P < 0.05); combined restriction of energy and protein decreased the activities of catalase and GR and the ratio of RNA to DNA in muscle, and the activities of SOD, GSH-Px and GR in spleen (P < 0.05). On day 105, there was no difference in the antioxidant parameters among four groups (P > 0.05); however, the weights of liver and spleen in groups of pre-protein restriction and pre-combined restriction of energy and protein were still less than those of kids in control. The results indicate that six weeks of nutritional restriction can reduce the antioxidant capacity of muscle, spleen and liver, retard the development of liver and spleen, and the retarded development partly continues even after nine weeks of nutritional recovery.

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“…There is a body of research which underlines the necessity of additional supplementation pointed to by the indicators of iron deficiency occurrence in the post-weaning period [7,10,36]. Growth potential in weaned piglets is high, which results in a rapid increase in blood volume and high nutritional iron requirements.…”

Section: Introductionmentioning

confidence: 99%

Can iron work for pigs as a booster?

Urbaniak

Spyrka

Rząsa

2017

Advances in Cell Biology

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Iron deficiency is a common health problem in mammals, especially in growing piglets hence iron administration to suckling piglets is a routine practice in swine production. A total number of 160 weaners were allotted to two experimental groups according to body weight (I -cachectic underweight piglets; II -piglets with appropriate weaning body weight). Additionally, each group was divided into two subgroups, with iron administered to piglets in subgroups IA and IIA on the first day of the experiment. In order to monitor the weight gains in pigs, they were weighed twice. To estimate the haematological status, blood samples were taken on the weaning day from selected piglets (10 in each subgroup). Haematological analyses were conducted using Hb, Ht, RBC, MCV, MCH, MCHC as early anaemia indicators. Additionally plasma iron (PI) and total iron-binding capacity (TIBC) were assessed as parameters of the actual and potential circulating extracellular iron. The aim of the study was to investigate the effect of additional postweaning Fe supplementation on production results. A lower concentration of PI was noted in weaker piglets (Group IA and IB). Throughout the experiment higher daily gains were noted in Group II; differences between Group IIA and IA as well as IB were statistically confirmed at p≤ 0,01. It might be expected that an additional Fe dose applied in weaning piglets can be used as a growth promoter. On the other hand, in case of cachectic animals toxicity of supplemental iron must be taken into consideration. Running title:

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The Impact of Suckling and Post-weaning Period on Blood Chemistry of Piglets

Cited by 24 publications

References 32 publications

Response to weaning and dietary l-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry

Response to weaning and dietary l-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry

Effects of Protein and/or Energy Restriction for Six Weeks, Followed with Nutritional Recovery on the Antioxidant Capacity and Development of Liver, Spleen and Muscle of Weaned Kids

Can iron work for pigs as a booster?

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