The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database

Zhang, Cuifen; Zhang, Xiaohong; Liu, Zeyu; Tao, Jiahao; Lin, Lizhu; Zhai, Linzhu

doi:10.1038/s41598-021-02597-1

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…4 In China, the main site of PGI-DLBCL is the stomach, followed by the small intestine, with non-specific clinical manifestations, which are prone to misdiagnosis and missed diagnosis. 5 Most previous studies [5][6][7] focused on primary gastric DLBCL(PG-DLBCL)/ intestinal DLBCL(PI-DLBCL), or all PGI-DLBCL. Few studies had separately investigated the potential prognostic variables in patients with primary small intestine DLBCL(PsI-DLBCL).…”

Section: Introductionmentioning

confidence: 99%

Clinical Features Analysis and Survival Nomogram of Primary Small Intestinal Diffuse Large B-Cell Lymphoma

Liu¹,

Cao²,

Liu³

et al. 2022

CMAR

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This study aimed to analyze the clinical features and survival of primary small intestinal diffuse large B-cell lymphoma (PsI-DLBCL), and establish and independently validate a prognostic nomogram for individual risk prediction. Patients and methods: Data for 24 patients from the Renmin Hospital of Wuhan University were used as an independent validation cohort, data for 1144 patients with PsI-DLBCL from the SEER database were randomly assigned to training (N=817) and internal validation (N=327) sets. The survival nomogram was constructed with the most significant factors associated with OS using Univariate and multivariate analyses on the training set. Decision curve analysis (DCA) was conducted. Internal validation was SEER validation set. Our cancer center cohort was used as an external validation set to further verify the survival nomogram. Results: Five clinicopathological feature factors associated with OS of the training set yielded (age, marital status, Ann Arbor stage, surgery for primary site and chemotherapy), which were used to create a survival nomogram. Additionally, the calibration curves of the prognostic nomogram revealed good agreement between the predicted survival probabilities and the ground truth values. The stability of our survival nomogram was explained by internal and external validation data. Conclusion: Our nomogram proposes the clinical and therapeutic factors affecting OS for patients with PsI-DLBCL. It shows that chemotherapy and surgery are beneficial to patients in the choice of treatment options. These results suggest that a survival nomogram may be better at predicting OS for PsI-DLBCL patients.

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Section: Introductionmentioning

confidence: 99%

Clinical Features Analysis and Survival Nomogram of Primary Small Intestinal Diffuse Large B-Cell Lymphoma

Liu¹,

Cao²,

Liu³

et al. 2022

CMAR

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The prognostic impact of lymphoma perforation in patients with primary gastrointestinal lymphoma – a single-center analysis

Modemann

Ahmadi

Kroge

et al. 2023

Leukemia & Lymphoma

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Primary pancreatic lymphoma: A case report and review of literature

Stojanovic,

Brzacki,

Marjanovic

et al. 2024

World J Clin Oncol

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BACKGROUND Primary pancreatic lymphoma (PPL) is a rare tumor that mimics pancreatic adenocarcinoma, leading to diagnostic and therapeutic challenges. PPL accounts for 0.2% of all pancreatic tumors and is typically treated with chemotherapy. However, the long-term survival rates for PPL with chemotherapy and radiotherapy alone are unsatisfactory. Due to the improvements in pancreatic surgery, there is a need to reevaluate the treatment strategies for PPL. CASE SUMMARY A 62-year-old male presented to our clinic. A biopsy was unsuccessful, and the imaging was suggestive of pancreatic adenocarcinoma. Therefore, subtotal splenopancreatectomy was performed and histopathology was performed. He was then diagnosed with primary pancreatic diffuse large B-cell lymphoma. He received adjuvant chemotherapy and radiotherapy. Currently, the patient is alive with no evidence of disease 36 months after surgery. CONCLUSION The potential role of surgery in the treatment of PPL should be emphasized and added in the management protocol of early stage lymphoma.

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The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database

Cited by 3 publications

References 34 publications

Clinical Features Analysis and Survival Nomogram of Primary Small Intestinal Diffuse Large B-Cell Lymphoma

Clinical Features Analysis and Survival Nomogram of Primary Small Intestinal Diffuse Large B-Cell Lymphoma

The prognostic impact of lymphoma perforation in patients with primary gastrointestinal lymphoma – a single-center analysis

Primary pancreatic lymphoma: A case report and review of literature

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