The impact of synchronous liver resection on the risk of anastomotic leakage following elective colorectal resection. A propensity score match analysis on behalf of the iCral study group

Guerra, Francesco; Petrelli, Filippo; Greco, Paola Antonella; Sisti, Valerio; Catarci, Marco; Montalti, Roberto; Patriti, Alberto; Alagna, Vincenzo; Amodio, Pietro Maria; Anania, Gabriele; Angeloni, Riccardo; Arici, Elisa; Baiocchi, Gian Luca; Baraghini, Maddalena; Benedetti, Michele; Bertocchi, Elisa; Borghi, Felice; Brisinda, Giuseppe; Campagnacci, Roberto; Capolupo, Gabriella Teresa; Caricato, Marco; Carrara, A.; Ceccaroni, Marcello; Chiarello, Maria Michela; Cianflocca, Desirée; Ciano, Paolo; Cicconi, Simone; Clementi, Maria Chiara; Delrio, Paolo; Cesare, Tatiana Di; Marco, Carlo Di; Falsetto, Alessandro; Garulli, Gianluca; Guadagni, Simone; Guercioni, Gianluca; Lambertini, M.; Liverani, Andrea; Longo, Graziano; Lucchi, Andrea; Luzzi, Andrea-Pierre; Palmieri, Raffaele; Mancini, Stefano; Marini, Pierluigi; Marsanic, Patrizia; Martino, Antonio; Martorelli, Giacomo; Marziali, Irene; Maurizi, Angela; Migliore, M.; Molfino, Sarah; Motter, Michele; Muratore, Andrea; Pace, Ugo; Pandolfini, Lorenzo; Pavanello, M; Pirozzi, Felice; Ruffo, Giacomo; Ruggeri, Benedetta; Sagnotta, Andrea; Santoni, Simone; Scabini, Stefano; Scatizzi, Marco; Sciuto, Antonio; Sica, Giuseppe; Tirone, Giuseppe; Tomassini, Federico; Vettoretto, Nereo; Zigiotto, Daniele

doi:10.1016/j.ejso.2021.05.042

Cited by 10 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Итальянской группой по исследованию колоректальных анастомозов (iCral) получены аналогичные результаты [44]. Так, частота несостоятельности анастомозов после комбинированных операций (симультанная резекция кишки и печени) не отличалась от таковой при изолированных колоректальных резекциях -9,4 vs 6,3 % (p=0,381).…”

Section: Introductionunclassified

Variability in surgical treatment of metastatic colorectal cancer (literature review)

et al. 2023

View full text Add to dashboard Cite

Background. Colorectal cancer (CRC) is one of the most common cancers and one of the most leading causes of cancer-related deaths worldwide. Approximately 35 % of CRC patients have liver metastases at the time of diagnosis. These patients have a poor prognosis, with the 5-year survival rate of 15 %. Given the poor survival with currently approved methods, the development of the optimal treatment options is needed.The purpose of the study was to search for data on the development of surgical techniques for the treatment of patients with metastatic CRC (mCRC) with isolated liver metastasis.Material and Methods. Literature search was carried out in Medline, Cochrane Library, Elibrary and Pubmed databases, including publications characterizing historical and modern results (from 1976 to 2021).Results. Liver resection in mCRC patients with isolated liver metastasis is the only treatment that offers a chance of increasing the 5-year survival rate up to 45–60 %. Radical surgery should include the removal of the primary tumor and all metastases with negative histological resection margins while preserving sufficient functional liver parenchyma. The paper discusses various approaches to surgical treatment of mCRC patients with liver metastases, with an assessment of their advantages and disadvantages, as well as presents data on perioperative and oncological outcomes.Conclusion. The surgical treatment strategy should be adapted for each mCRC patient with synchronous liver metastases. The core function of a multidisciplinary team is to determine the patient’s treatment plan combining surgery and systemic chemotherapy, which will improve the immediate and long-term treatment outcomes.

show abstract

Section: Introductionunclassified

Variability in surgical treatment of metastatic colorectal cancer (literature review)

et al. 2023

View full text Add to dashboard Cite

show abstract

Laparoscopic versus open resection of primary colorectal cancers and synchronous liver metastasis: a systematic review and meta-analysis

Morărașu

Clancy

Görgün

et al. 2023

Int J Colorectal Dis

View full text Add to dashboard Cite

Purpose Combined resection of primary colorectal cancer and associated liver metastases is increasingly common. This study compares peri-operative and oncological outcomes according to surgical approach. Methods The study was registered with PROSPERO. A systematic search was performed for all comparative studies describing outcomes in patients that underwent laparoscopic versus open simultaneous resection of colorectal primary tumours and liver metastases. Data was extracted and analysed using a random effects model via Rev Man 5.3 Results Twenty studies were included with a total of 2168 patients. A laparoscopic approach was performed in 620 patients and an open approach in 872. There was no difference in the groups for BMI (mean difference: 0.04, 95% CI: 0.63–0.70, p = 0.91), number of difficult liver segments (mean difference: 0.64, 95% CI:0.33–1.23, p = 0.18) or major liver resections (mean difference: 0.96, 95% CI: 0.69–1.35, p = 0.83). There were fewer liver lesions per operation in the laparoscopic group (mean difference 0.46, 95% CI: 0.13–0.79, p = 0.007). Laparoscopic surgery was associated with shorter length of stay (p < 0.00001) and less overall postoperative complications (p = 0.0002). There were similar R0 resection rates (p = 0.15) but less disease recurrence in the laparoscopic group (mean difference: 0.57, 95% CI:0.44–0.75, p < 0.0001). Conclusion Synchronous laparoscopic resection of primary colorectal cancers and liver metastases is a feasible approach in selected patients and does not demonstrate inferior peri-operative or oncological outcomes.

show abstract

Predicting Limited Survival After Resection of Synchronous Colorectal Liver Metastases: a Propensity Score Matched Comparison Between The Primary First And The Simultaneous Strategy

Addeo

Foguenne

Guerra

et al. 2023

Journal of Gastrointestinal Surgery

View full text Add to dashboard Cite

The impact of synchronous liver resection on the risk of anastomotic leakage following elective colorectal resection. A propensity score match analysis on behalf of the iCral study group

Cited by 10 publications

References 37 publications

Variability in surgical treatment of metastatic colorectal cancer (literature review)

Variability in surgical treatment of metastatic colorectal cancer (literature review)

Laparoscopic versus open resection of primary colorectal cancers and synchronous liver metastasis: a systematic review and meta-analysis

Predicting Limited Survival After Resection of Synchronous Colorectal Liver Metastases: a Propensity Score Matched Comparison Between The Primary First And The Simultaneous Strategy

Contact Info

Product

Resources

About