The purpose of this article is to analyse the impact of telework on the work-life balance, productivity, and health of different generations of Romanian employees. Qualitative and quantitative methods provide the means to exploit the richness of data and deepen the understanding of the phenomenon studied. The quantitative data derived from a research instrument was associated with qualitative data collection. Quantitative research was conducted to achieve the stated purpose using the survey method, the number of respondents being 1098 persons. The research tool was an online questionnaire. Results highlight how telework affected each generation of employees. The satisfaction towards teleworking achieved by Generation Z and Baby Boomers is, on average, higher than that of Generation Y and X. The differences between the age groups (Generation Z, Y, X, and Baby Boomers) in terms of telework satisfaction levels were also tested, considering each of the three aspects examined and presented in the article’s title. At the conceptual level, research brings a new methodological approach as an element of originality that can be used for similar future research. Moreover, new concepts on the effects of telework on employees were connected and analysed simultaneously: work-life balance, productivity, and health of employees during teleworking. At the operational level, this type of research can determine the degree of satisfaction of employees in different companies/organizations and identify solutions to increase employee engagement.