The impact of temperature and pump flow rate during selective cerebral perfusion on regional blood flow in piglets

Abstract

SCP at 32°C provides higher brain RBF 2 hours after CPB. Increasing SCP flow rate does not increase RBF significantly at 25°C. Higher temperature during SCP results in improved RBF to the liver and quadriceps.

Outcomes after One-Stage Repair of Coarctation of the Aorta and Combined Intracardiac Lesions in Infants

“…По мере снижения летальности в этой группе пациентов обнажилась потенциальная угроза развития неврологических осложнений, связанных с применени-ем метода ГЦА. С внедрением в практику метода СЦП было описано снижение частоты возникновения невро-логических осложнений в сравнении с методом ГЦА как в клинической практике [1][2][3], так и в эксперименте [4,5]. Интерес к методу СЦП возрос с появлением ряда публикаций, посвященных совершенствованию техники СЦП при реконструкции аорты, что позволило снизить длительность ГЦА или же полностью исключить его [6][7][8][9][10][11].…”

Innominate Artery Cannulation and Antegrade Cerebral Perfusion for Aortic Arch Reconstruction in Infants and Children

“…These include both the flow rates and the temperatures necessary to achieve maximal brain protection. 12,[20][21][22] We use flow rates of 40 mL/kg/min at a temperature of 25 C. However, there is a wide range of flow rates and temperatures reported in the existing literature. In addition, there is some debate regarding the extensiveness of the monitoring systems that might lead to optimized brain protection.…”

Surgical approaches for CHD

“…An animal study from the University of Texas Southwest Medical Center examined regional blood flow in brain and lower body and the relationship with degree of hypothermia and flow rates during SCP [13]. They utilized a piglet model of cardiopulmonary bypass, SCP, and fluorescent microsphere injection to quantitate regional blood flow.…”