The impact of temporomandibular joint arthritis on functional disability and global health in patients with juvenile idiopathic arthritis

Isola, Gaetano; Perillo, Letizia; Migliorati, Marco; Matarese, Marco; Dalessandri, Domenico; Grassia, Vincenzo; Alibrandi, Angela; Matarese, Giovanni

doi:10.1093/ejo/cjy034

Cited by 58 publications

(74 citation statements)

References 32 publications

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“…AMPs are more specific and efficient than common antibiotics and are related to lower cell and tissue toxicity [12]. Nowadays, we know of more than 40 antimicrobial peptides in the oral cavity and many of these play a pivotal role in periodontal diseases as well as in orthodontics [13,14].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

et al. 2020

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Featured Application: Indolicidin-coated silver nanoparticles could be used as platforms in the dental field as oral disease preventive drug. Furthermore, nanomaterials could prevent oral cancers and balance oral health care. Abstract:(1) Background: In dentistry, silver nanoparticles (AgNPs) have progressively earned great interest as antimicrobial drugs and are widely used in several biomedical fields. Recent progress in the analysis of complex bacterial communities has demonstrated the richness of the oral microbiota and the presence of numerous previously unexplained strains. Several efforts have been dedicated to the investigation of antimicrobial peptides (AMPs). Those peptides are a widespread group of small peptides against invading microbes. We report the production of a hybrid molecule composed of AgNPs and indolicidin, a well-known antibacterial peptide. (2) Methods: Spectroscopy and microscopy were used to analyze the optical features and to determine the size of the generated AgNPs. The AgNP antibacterial activity was evaluated versus oral Gram-positive and Gram-negative bacteria.(3) Results: The coated nanoparticles' antibacterial activity strongly inhibited the growth of microorganisms, with very low minimum inhibitory concentration (MIC) values in the range of 5-12.5 µg/mL. We hypothesize that this effect depended on the specific characteristics of the metal surface coated with indolicidin. The second result was that the coated nanoparticles observed cellular toxicity, was lower with respect to the toxicity of peptide and the naked AgNPs when used individually. (4) New investigations regarding antimicrobial effect of AgNPs coated with AMPs in oral infections are an urgent task.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

et al. 2020

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“…The use of skeletal anchorage is getting widespread among orthodontists since it facilitates the management of complex orthodontic biomechanics; as a consequence, skeletal anchorage can be useful in treating borderline cases such as transversal maxillary deficiency in adults. In this respect, miniscrews-assisted rapid maxillary expansion was found to effectively open the mid-palatal suture in adults without the necessity to undergo orthognathic surgery [12,24,[28][29][30][31][32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of skeletal anchorage, however, relies on specific characteristics that can affect primary and secondary stability of the miniscrew [30]. The availability of sufficient supporting bone and the perforation of both cortical laminas (bi-corticalism) are two mandatory parameters for mini-screw stability, especially when orthopedic forces are used, as during skeletal maxillary expansion.…”

Section: Discussionmentioning

confidence: 99%

“…The availability of sufficient supporting bone and the perforation of both cortical laminas (bi-corticalism) are two mandatory parameters for mini-screw stability, especially when orthopedic forces are used, as during skeletal maxillary expansion. In this respect, a quantitative and qualitative evaluation of bone characteristics [30][31][32][33][34][37][38][39][40], as well as the assessment of the most suitable position of the miniscrews in the palate, are critical for the success of maxillary expansion assisted by skeletal anchorage. In this paper, we followed the recent guidelines for digital workflow planning proposed by Cantarella et al [23] for the MSE appliance, however, we utilized the patient CBCT DICOM file that allows discriminating between cortical and cancellous bone.…”

Section: Discussionmentioning

confidence: 99%

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Description of a Digital Work-Flow for CBCT-Guided Construction of Micro-Implant Supported Maxillary Skeletal Expander

et al. 2020

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The introduction of miniscrew-assisted rapid palatal expansion (MARPE) has widened the boundaries of orthodontic skeletal correction of maxillary transversal deficiency to late adolescence and adult patients. In this respect, Maxillary Skeletal Expander (MSE) is a particular device characterized by the engagement of four miniscrews in the palatal and nasal cortical bone layers. Thus, the availability of sufficient supporting bone and the perforation of both cortical laminas (bi-corticalism) are two mandatory parameters for mini-screw stability, especially when orthopedic forces are used. Virtual planning and construction of MSE based on cone-beam computed tomography (CBCT)-derived stereolithography (.stl) files have been recently described in the literature. In this manuscript we described: (a) a user-friendly digital workflow which can provide a predictable placement of maxillary skeletal expander (MSE) appliance according to the patient’s anatomical characteristics, (b) the construction of a positional template of the MSE that allows lab technician to construct the MSE appliance in a reliable and accurate position, according to the virtual project planned by the orthodontist on the patient CBCT scans. We also described a case report of an adult female patient affected by skeletal transversal maxillary deficiency treated with MSE appliance that was projected according to the described workflow.

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“…Dental and skeletal malocclusion that left untreated can lead to temporomandibular disorder (TMD) such as TMJ arthritis, which can affect oral health related to quality of life (OHRQoL) in adolescents. 9 Nowadays, many studies found that polymorphism/ gene variation also can be the cause of malocclusion. [10][11][12] Previous studies stated that the development of malocclusion was affected by human evolution and some genetic factors, including the muscle fibers plasticity and heterogeneity of both jaw skeletal morphology and masticatory muscle, which can be inherited.…”

Section: Introductionmentioning

confidence: 99%

<p>Single Nucleotide Polymorphisms (SNPs) of COL1A1 and COL11A1 in Class II Skeletal Malocclusion of Ethnic Javanese Patient</p>

Ardani¹,

Aulanni’am²,

Diyatri³

2020

CCIDE

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Background: The prevalence of malocclusion cases in the orthodontic specialist clinic in Airlangga University's Dental Hospital in Surabaya, Indonesia, in 2014-2016 is fairly high, as 55.34% of the occurrences were identified as class II skeletal malocclusion. This type of skeletal malocclusion, which is usually recognized in adults, occurs as a result of variation during growth and development. Lately, there have been many reports on gene polymorphisms of COL1A1 and COL11A1, which are assumed to be associated with class II skeletal malocclusion in Caucasians. Purpose: This study aims to analyze the relationship between single nucleotide polymorphisms (SNPs) of COL1A1 and COL11A1 with class II skeletal malocclusion in Javanese ethnic group patients with mandibular micrognathism. Materials and Methods: The diagnosis of class II skeletal malocclusion was established using the lateral cephalometric radiographs (ANB angle ≥4°) (n=50). DNA was extracted from the patient's peripheral blood. After that, PCR, electrophoresis, and DNA sequencing were conducted on the extracted DNA based on COL1A1 and COL11A1 primers. Results: The SNPs in COL1A1 are c.20980G/A in 27 patients and c.20980G>A in 8 patients, whereas SNPs in COL11A1 are both c.134373C/A and c.134555C/T in 8 patients and both c.[134373A>C] and c.134582G>A in 10 patients. All samples show the deletion (c. [134227delA]) in COL11A1. Conclusion: SNPs in COL1A1 and COL11A1 have been found in class II skeletal malocclusion of Javanese ethnic group patients. Seventy percent of SNPs in COL1A1 occur in rs.2249492, whereas 36% of newly discovered SNPs appear in COL11A1. All samples also have deletion in COL11A1.

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The impact of temporomandibular joint arthritis on functional disability and global health in patients with juvenile idiopathic arthritis

Abstract: JIA patients with TMJ arthritis presented higher functional disability and lower OHRQoL scores compared with JIA patients without TMJ arthritis. TMJ arthritis was strongly associated with JIA duration and activity, especially in female patients.

Cited by 58 publications

References 32 publications

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

Description of a Digital Work-Flow for CBCT-Guided Construction of Micro-Implant Supported Maxillary Skeletal Expander

<p>Single Nucleotide Polymorphisms (SNPs) of COL1A1 and COL11A1 in Class II Skeletal Malocclusion of Ethnic Javanese Patient</p>

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