The Impact of Testicular Cancer on Fertility - Literature Review

Abstract

This article is a literature review that emphasis the impact of testicular cancer on fertility and current management to prevent and treat infertility. Foreign literature has a lot of multicenter prospective longitudinal and retrospective studies of negative effects on fertility in men with teticular cancer. Testicular cancer has a negative impact on fertility because of its high incidence (7.52 cases per 100000 of the population) in young men with age between 15 and 35 years old. At the time they discover they have testicular cancer, many man have few or no sperm. In addition, all of the treatment for testicular cancer can directly or indirectly cause fetility problems. Sperm abnormatilies are frequent in men with testicular cancer. Patiens who underwent chemotherapy with bleomicin, doxorubicin, cisplatin or radiotherapy have a high risk to develop sperm aneuploidy. Genetic and psychological counseling should be done before choosing any treatment for testicular cancer. Sperm and embryo cryopreservation should be considered as early as possible before any treatement for testicular cancer.