The impact of testosterone imbalance on depression and women's health

Rohr, Uwe D.

doi:10.1016/s0378-5122(02)00013-0

Cited by 101 publications

(65 citation statements)

References 95 publications

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“…The loss of 17β-estradiol (and inhibin) signaling also may be important for the demise of female O. nerka (Table 2; Jeffries et al 2011), as supported by the high 17β-estradiol concentrations in O. nerka prior to spawning (Table 2), and the lack of a decrease in testosterone signaling in post-menopausal women with aging (Rohr 2002). Although post-spawning female O. nerka circulating 17β-estradiol (and male O. nerka testosterone) is considerably higher than in mammals, their relative concentration declines by a far greater extent (Tables 2, 3, 4, and 5), thereby triggering robust dyotic signaling.…”

Section: Between Species Analysismentioning

confidence: 95%

Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species

et al. 2017

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Post-reproductive lifespan varies greatly among species; human post-reproductive lifespan comprises~30-50% of their total longevity, while semelparous salmon and dasyurid marsupials post-reproductive lifespan comprises <4% of their total longevity. To examine if the magnitude of hypothalamic-pituitarygonadal (HPG) axis dyscrasia at the time of reproductive senescence determines post-reproductive lifespan, we examined the difference between pre-and postreproductive (1) circulating sex hormones and (2) the ratio of sex steroids to gonadotropins (e.g., 17β-estradiol/follicle-stimulating hormone (FSH)), an index of the dysregulation of the HPG axis and the level of dyotic (death) signaling post-reproduction. Animals with a shorter post-reproductive lifespan (<4% total longevity) had a more marked decline in circulating sex steroids and corresponding elevation in gonadotropins compared to animals with a longer post-reproductive lifespan (30-60% total longevity). In semelparous female salmon of short post-reproductive lifespan (1%), these divergent changes in circulating hormone concentration postreproduction equated to a 711-fold decrease in the ratio of 17β-estradiol/FSH between the reproductive and post-reproductive periods. In contrast, the decrease in the ratio of 17β-estradiol/FSH in iteroparous female mammals with long post-reproductive lifespan was significantly less (1.7-34-fold) post-reproduction. Likewise, in male semelparous salmon, the decrease in the ratio of testosterone/FSH (82-fold) was considerably larger than for iteroparous species (1.3-11-fold). These results suggest that (1) organisms with greater reproductive endocrine dyscrasia more rapidly undergo senescence and die, and (2) the contribution postreproduction by non-gonadal (and perhaps gonadal) tissues to circulating sex hormones dictates postreproductive tissue health and longevity. In this way, reproduction and longevity are coupled, with the degree of non-gonadal tissue hormone production dictating the rate of somatic tissue demise post-reproduction and the differences in post-reproductive lifespans between species.

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Section: Between Species Analysismentioning

confidence: 95%

Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species

et al. 2017

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“…T may have different effects depending on if it is the so called female (subcutaneous fat) or the male (visceral fat) obesity that is considered [16][17][18][19] . Steroid Hormone Binding Globulin (SHBG) concentrations are in some studies negatively correlated with body mass index (BMI) and WHR 17,[20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Götmar

Hammar

Fredrikson³

et al. 2008

Climacteric

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Objectives: The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Results: 6908 women participated. The women on HRT had lower T and FTI and were less satisfied with mood and energy (p<0.05). Women with hot flushes had higher T and FTI and women reporting coldness had lower concentrations (p<0.05). Sexual well-being were not correlated to T or FTI (p>0.05).Conclusions: Lower T concentrations were associated with lower quality of life in perimenopausal women but not to sexual well-being. There must be other factors than 3 decrements in sex hormones that contribute to the emergence of some perimenopausal symptoms.

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“…This was contrary to common belief, since exercise stimulates testosterone (Rohr, 2002) a libido-dependent hormone that affects sex drive, sexual interest and sexual function (Penhollow & Young, 2008). When men were isolated in the analysis, there were no relationships found between testosterone producing activities (cardiovascular endurance, muscular endurance and muscular strength) and the number of sexual partners.…”

Section: Sexual Partnersmentioning

confidence: 79%

“…Exercise stimulates testosterone, a libido-dependent hormone (Rohr, 2002), and the sympathetic nervous system, which triggers blood flow to the genital region (Meston 2000). Similarly, Stanten and Yeager (2003) also found that even low levels of physical activity can keep sex organs in better working condition.…”

Section: Exercise and Sexual Functionmentioning

confidence: 97%

“…Although previous studies found relationships between exercise and sex drive (Bortz & Wallace, 1999;Esposito et al, 2004;Goh & Tong, 2009;Paduch, et al, 2013;Palmeri et al, 2007;Penhollow & Young, 2004;Rohr, 2002;Stanten & Yeager, 2003), a review of the literature review did not produce a study that examined the relationship between total sexual functioning and all five components of physical fitness that is cardiovascular endurance, muscular strength, muscular endurance, flexibility and body composition.…”

Section: Sexual Dysfunctionmentioning

confidence: 97%

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Sex-Positive Curricula: An Investigation of the Relationship Between Physical Fitness, Self-Concept and Sexual Functioning

Jiannine¹

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The impact of testosterone imbalance on depression and women's health

Cited by 101 publications

References 95 publications

Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species

Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species

Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Sex-Positive Curricula: An Investigation of the Relationship Between Physical Fitness, Self-Concept and Sexual Functioning

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