Introduction
There have been studies revealing hypocalcemia in severe covid-19 and low vitamin D levels that warranted further studies.
Objective
Our study investigates the correlation between calcium levels at presentation as a primary endpoint, and pre-existing calcium levels as a secondary endpoint, to severity of disease presentation and progression.
Method
Observational cohort study in adults admitted with COVID-19 from March till September 2020. Multiple clinical scales, laboratory parameters, were used to correlate corrected calcium and vitamin D associations with risk factors and outcomes.
Results
Around 445 patients were included in the study. Hypocalcemic patients had more abnormal laboratory parameters and longer hospitalization duration. Hypocalcemia was in 60-75% of all age groups (p-value 0.053), for which 77.97% were ICU admissions (p-value 0.001) and 67.02% were diabetic (p-value 0.347). There were non-significant correlations between Vitamin D and almost all the parameters except for chronic respiratory diseases with P value of 0.024.
Conclusion
It can be concluded that hypocalcemia is a significant and reliable marker of disease severity and progression regardless of underlying comorbidities. Meanwhile, Vitamin D levels fail to reflect correlation with severity of COVID-19 infections.