The scientific article is devoted to the study of economic risks in the activities of enterprises of the agro-industrial complex in the context of import substitution. The purpose of the scientific research is to identify critical risks in the activities of enterprises of the agro-industrial complex in the context of import substitution and to substantiate possible measures to level them. When preparing a scientific publication, general scientific (observation, comparison, measurement, analysis and synthesis, the method of logical reasoning) and specific scientific methods (static analysis, peer review, graphical method, Foresight's "4 worlds" method) were used. Results: the critical risks for the normal functioning of agro-industrial enterprises are: 1) the occurrence of a shortage of seed material; 2) raw material dependence of manufacturers of plant protection products against pests; 3) the critical dependence of the Russian agro-industrial complex on the import of feed additives and vaccines aimed at realizing the genetic potential of animal breeds; 4) degradation of the genetic fund of biological assets bred in animal husbandry with insufficient experience in genetic modeling and domestic selection; 5) technological dependence of the digitalization of business processes in the agro-industrial complex on technology transfer and a decrease in innovative activity in agribusinesses. The main efforts to resolve the existing risks are: active support for domestic seed producers through the provision of tax incentives and other regulatory preferences; creation of a national standard for the formation and storage of data - Big GeoData, which will become the basis for the formation of the domestic market of digital agricultural technologies; creation of full-fledged domestic productions based on gaining access to technologies for the creation of plant protection products and tracking the latest developments by