The impact of the introduction of hydrolyzed cellulose on the thermal and mechanical properties of LDPE composites

Paula, Carlos T. B.; Rebelo, Rafael C.; Coelho, Jorge F. J.; Serra, Arménio C.

doi:10.1007/s00107-019-01457-0

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…The carboxylate content of oxidized cellulose beads was determined by conductometric titration based on the procedure reported by Paula et al [ 27 ]. In short, 13 g wet OCBs-1 to 4 (approx.…”

Section: Methodsmentioning

confidence: 99%

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

et al. 2021

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The development of controlled drug delivery systems based on bio-renewable materials is an emerging strategy. In this work, a controlled drug delivery system based on mesoporous oxidized cellulose beads (OCBs) was successfully developed by a facile and green method. The introduction of the carboxyl groups mediated by the TEMPO(2,2,6,6-tetramethylpiperidine-1-oxyradical)/NaClO/NaClO2 system presents the pH-responsive ability to cellulose beads, which can retain the drug in beads at pH = 1.2 and release at pH = 7.0. The release rate can be controlled by simply adjusting the degree of oxidation to achieve drug release at different locations and periods. A higher degree of oxidation corresponds to a faster release rate, which is attributed to a higher degree of re-swelling and higher hydrophilicity of OCBs. The zero-order release kinetics of the model drugs from the OCBs suggested a constant drug release rate, which is conducive to maintaining blood drug concentration, reducing side effects and administration frequency. At the same time, the effects of different model drugs and different drug-loading solvents on the release behavior and the physical state of the drugs loaded in the beads were studied. In summary, the pH-responsive oxidized cellulose beads with good biocompatibility, low cost, and adjustable release rate have shown great potential in the field of controlled drug release.

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Section: Methodsmentioning

confidence: 99%

TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

et al. 2021

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Novel thermally regenerated flexible cellulose-based films

Moreira,

Rebelo,

Coelho

et al. 2024

Eur. J. Wood Prod.

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In this work, cellulose powder obtained by acid hydrolysis of industrial Eucalyptus kraft pulp was dissolved in NaOH/Urea/H2O system (7/12/81 wt%) in a concentration of 6% (w/v). Cellulose films were prepared by spreading the dissolved cellulose over glass plates, followed by thermal regeneration – a novel approach reported here for the first time. To obtain final flexible films, plasticization was carried out by immersion in aqueous glycerol solutions of various concentrations (10 to 70 wt%) and hot-pressing (at 0.1 MPa and 105 ºC) was used to dry and compress the cellulose films. The resulting films were characterized by Attenuated Total Reflectance Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, contact angle measurements, transparency analysis, and gas permeabilities (oxygen and water vapor). Highly flexible films containing up to 50 wt% of glycerol were successfully obtained, exhibiting no glycerol release upon manual handling. Overall, the produced films demonstrated dense and compact structure, good transparency, flexibility and malleability, and very low oxygen permeability.

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