Phytoplankton, an assemblage of suspended, primarily autotrophic single cells and colonies, forms part of the base of the pelagic food chain in lakes. The responses of phytoplankton to anthropogenic pressures frequently provide the most visible indication of a long-term change in water quality. Several attributes related to the growth and composition of phytoplankton, such as their community structure, abundance as well as the frequency and the intensity of blooms, are included as indicators of water quality in the Water Framework Directive. The growth and seasonal succession of phytoplankton is regulated by a variety of external as well as internal factors (Reynolds et aI., 1993;Reynolds, 2006). Among the most important external factors ate light, temperature, and those associated with the supply of nutrients from point and diffuse sources in the catchment. The internal factors include the residence time of the lakes, the underwater light regime and the mixing characteristics of the water column. The schematic diagram (Fig. 14.1) shows some of the ways in which systematic changes in the climate can modulate these seasonal and inter-annual variations. The effects associated with the projected changes in the rainfall are likely to be most pronounced in small lakes with shOlt residence times (see George et aI., 2004 for some examples). In contrast, those connected with the projected changes in irradiance and wind mixing, are likely to be most important in deep, thermally stratified lakes.In this chapter, we use results acquired from a range of different European lakes to explore the potential effects of climate change on the seasonal development and the composition of phytoplankton. The time-series analysed are amongst the longest available in the region. Some of the lakes studied in CLIME have been sampled at weekly or fortnightly intervals for more than fifty years. These sites also cover a range of lake types from shallow to deep, small to large, and oligotrophic to eutrophic. P. Noges ([8)