Designing masonry structures or any other structures involves ensuring an adequate level of safety. This is done by applying the appropriate set of partial factor for strength and partial factors for actions in accordance with the recommendations of the Eurocodes. The paper presents an analysis of the reliability of a compressive masonry structure on the example of a wall fragment made of silicate blocks. The relationship between partial factors applied to actions in various configurations and factors for the compressive strength of masonry was investigated. The analyses consisted in determining the reliability index β using the First Order Reliability Method (FORM). The results are presented in diagrams with reference to different construction classes execution of works, as well as different reliability classes from RC1 to RC3.