Summary Accumulating evidence indicates the multifaceted nature of social support. Although support seekers may receive help, they may also encounter upsetting responses. It remains unclear how seeking and receiving social support, when differentiated, are associated with individuals’ strengths and well-being. This study collected survey data from 357 adults recruited from the southeastern United States. We classified participants using the factors of support seeking and support received into four groups: Interconnected (high on support seeking and receiving), Tended (low on support seeking, high on support receiving), Rebuffed (high on support seeking, low on support receiving), and Isolated (low on support seeking and receiving). We then examined the differences among groups. Findings The study found significant differences among the four groups in measures of regulatory strengths, meaning-making strengths, interpersonal strengths, and perceived well-being. In general, the Interconnected group scored highest among the four groups, followed by the Tended group, the Rebuffed group, and lastly, the Isolated group. Applications The finding that the Rebuffed group did not score significantly lower than the Isolated group underscores the importance of support seeking. Individuals may benefit from the support seeking process even though they do not obtain the support needed. Social work practitioners should facilitate and optimize their clients’ support seeking, including removing clients’ barriers to support seeking and addressing clients’ negative experiences in the support seeking process. Social work researchers should measure multiple aspects of social support, including support received and support seeking.