The impact of the type of resection on survival in patients with N1 non-small-cell lung cancers

Aydoğmuş, Ümit; Cansever, Levent; Sönmezoğlu, Yaşar; Karapınar, Kemal; Kocatürk, Celalettin; Bedirhan, Mehmet Ali

doi:10.1016/j.ejcts.2009.07.021

Cited by 4 publications

(7 citation statements)

References 14 publications

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“…[1,4,5] In addition, a number of studies have examined the factors related to long-term survival. [6][7][8] However, the incidence and the mechanism of circulatory and respiratory failure in the long-term is unclear.…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for malignancy-unrelated long-term respiratory events after pneumonectomy

Aydoğmuş¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada pnömonektomi sonrası geç başlangıçlı maligniteden bağımsız solunum olayları değerlendirildi.Ça lış mapla nı:Ocak 2009 -Eylül 2014 tarihleri arasında kliniğimizde pnömonektomi geçirmiş 78 hastanın (73 erkek, 5 kadın; ort. yaş 55.6±9.6 yıl; dağılım 32-79 yıl) tıbbi verileri retrospektif olarak incelendi. Ameliyat öncesinde sigara içme alışkanlıkları, eşlik eden hastalıklar, Amerikan Anesteziyoloji Derneği risk skoru, EuroSCORE, neoadjuvan kemoterapi ihtiyacı, kanser hücre tipi ve klinik evre kaydedildi. Ameliyat sonrasında komplikasyonlar ve uygulanan tedavi yöntemlerine ilişkin veriler kaydedildi. Bul gu lar:Ortalama takip süresi 35.2±22.0 ay (dağılım 9-104 ay) idi. Hastaların 21'inde (%35.0) lokal nüks ve ikinci primer akciğer tümörü gibi malignite ile ilişkili solunum olayı gelişti. Malignite ile ilişkisiz solunum olayları 18 hastada (%31.6) görüldü. Amerikan Anesteziyoloji Derneği skoru yüksek olan (p= 0.01), ameliyat öncesi birinci saniyedeki zorlu ekspiratuvar volüm <%60 olan (p= 0.05) ve EuroSCORE'u yüksek olan (p= 0.04) hastalarda uzun dönem, malignite ile ilişkisiz morbidite daha yaygın idi. Çok değişkenli analizde, Amerikan Anesteziyoloji Derneği skoru yüksek olan (p= 0.01) ve ameliyat öncesi birinci saniyedeki zorlu ekspiratuvar volüm <%60 olan (p= 0.03) hastalarda malignite ile ilişkisiz solunum olayları istatistiksel olarak anlamlı düzeyde daha sık idi.So nuç:Çalışma sonuçlarımız pnömonektomi yapılan hastalarda hem kısa dönem hem de uzun dönem solunum morbiditelerinin gelişebileceğini ve Amerikan Anesteziyoloji Derneği skoru yüksek olan ve ameliyat öncesi birinci saniyedeki zorlu ekspiratuvar volümü düşük olan hastalarda malignite ile ilişkisiz morbidite riskinin artmış olduğunu göstermektedir.Anah tarsöz cük ler: Kanser; uzun dönem bakım; akciğer; pnömonektomi. ABSTRACTBackground:In this study, we aimed to evaluate late-onset, malignancyunrelated respiratory events following pneumonectomy.

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Section: Resultsmentioning

confidence: 99%

“…[1,4,7,9] However, the long-term implications of these risk factors are not well-known. Long-term survival after pneumonectomy is primarily associated with the stage of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for malignancy-unrelated long-term respiratory events after pneumonectomy

Aydoğmuş¹

2017

Turk Gogus Kalp Dama

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“…They are mainly based on statistical modelling, including Kaplan-Meier curves, hierarchical statistical models, logistic and Cox regressions [4], [5], [6], [7]. Other approaches make use of logistic regression models to construct the so-called scoring tables.…”

Section: Related Workmentioning

confidence: 99%

“…Create S N (F k ) from S N by selecting only attributes from F k ; 3 Eliminate examples containing missing values from S N (F k ); 4 Train base learner h k on S N (F k ); 5 Calculate GMean value G k on S N (F k ) achieved by h k ; 6 …”

Section: B Creating Ensemble Classifiermentioning

confidence: 99%

Ensemble SVM for imbalanced data and missing values in postoperative risk management

Zięba

Świątek

2013

2013 IEEE 15th International Conference on E-Health Networking, Applications and Services (Healthcom 2013)

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In this work, we propose the ensemble SVM that solves the problem of missing values of attributes and the imbalanced data phenomenon in the domain of postoperative risk management. Contrary to the other approaches the our solution effectively deals with the problems of high percentage of unknown values of the features. The problem of imbalanced data is solved by applying the cost-sensitive SVM as a base classifier of an ensemble, The quality of the proposed classifier is examined on a real-life dataset.

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“…Lobectomy is the gold standard, but some studies have suggested better survival after pneumonectomy. 15 – 18 The aim of this single-institution study was to evaluate the prognostic factors in resected N1 disease, focusing on node descriptors (with the current and new IASLC proposed TNM staging systems) and surgical procedure.…”

Section: Introductionmentioning

confidence: 99%

N1 non-small-cell lung cancer. A 20-year surgical experience

Casali

Stefani

Morandi

2011

Asian Cardiovasc Thorac Ann

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N1 non-small-cell lung cancer has heterogeneous prognosis in relation to node descriptors. There is no agreement on the ideal type of resection. A new classification of N1 descriptors was proposed in the 7(th) edition of the TNM staging system. A retrospective study was conducted on 384 patients with T1-T3N1 non-small-cell lung cancer who underwent complete pulmonary resection. The prognostic role of N1 descriptors according to the current and new staging systems and type of resection was investigated. The 5-year survival rate was 46%. Involvement of hilar node stations, multiple stations, and multiple nodes were poor prognostic factors (5-year survival, 33%, 21%, and 30%, respectively), as well as involvement of the hilar zone and multiple zones (5-year survival, 27% and 23%, respectively). Pneumonectomy showed significantly better survival rates compared to lobectomy or bilobectomy (5-year survival, 60% vs. 29%). Multivariate analysis showed that the number of N1 zones and type of resection were independent prognostic factors. Patients with hilar nodal, multiple-level, or multiple-zone involvement had poor prognosis. Standard lobectomy remains the procedure of choice, but in cases of fixed nodes in the hilar zone, sleeve resection or even pneumonectomy should be considered.

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The impact of the type of resection on survival in patients with N1 non-small-cell lung cancers

Abstract: Those who had PN or BL had a higher survival rate, which was statistically insignificant. Further studies are required to determine whether or not the type of resection should be changed as a result of N1 only.

Cited by 4 publications

References 14 publications

Risk factors for malignancy-unrelated long-term respiratory events after pneumonectomy

Risk factors for malignancy-unrelated long-term respiratory events after pneumonectomy

Ensemble SVM for imbalanced data and missing values in postoperative risk management

N1 non-small-cell lung cancer. A 20-year surgical experience

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