The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, Akiko; Nakazato, Risa; Suhara, Yoshitomo; Shibata, Masahiro; Fukui, Toshiki; Ishii, Takeshi; Asanuma, Toshimichi; Mochizuki, Kiyofumi; Nakayama, Tsutomu; Osakabe, Naomi

doi:10.1016/j.jnutbio.2016.01.012

Cited by 22 publications

(13 citation statements)

References 32 publications

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“…(9,10) We previously reported that repeated treatment with theaflavins showed a significant reduction of blood pressure in rodents. (11) In addition, a single dose of theaflavins enhanced energy expenditure with an increase in proliferator-activated receptor gamma coactivator-1a (PGC-1a) transcription resulting in acceleration of AMP-activated protein kinase (AMPK) phosphorylation in mouse skeletal muscle. (12) We also reported previously that 10 weeks' supplementation of a theaflavins-rich capsule improved body composition, including a reduced ratio of body and subcutaneous fat and increased skeletal muscle percentage in healthy subjects.…”

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confidence: 99%

Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice

Suzuki

Hirashima

Fujii

et al. 2021

J. Clin. Biochem. Nutr.

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confidence: 99%

Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice

Suzuki

Hirashima

Fujii

et al. 2021

J. Clin. Biochem. Nutr.

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“…One study found an association between the consumption of theaflavin-enriched tea extracts and reduced levels of cholesterol [66], though this effect was not observed when purified theaflavins were administered [67]. Theaflavins, tea extracts, and tea also demonstrated promising results in psychophysiological stress [68] and the alteration of microvascular function [69], though more data are required. What was not addressed was the possibility that other compounds may significantly contribute to the therapeutic efficacy of tea, and the clinical usefulness of theaflavins is still far from conclusive.…”

Section: Health Benefits Of Common Dietary Flavonoids and Stilbenes Vmentioning

confidence: 99%

Flavonoids and Related Members of the Aromatic Polyketide Group in Human Health and Disease: Do They Really Work?

et al. 2020

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Some aromatic polyketides such as dietary flavonoids have gained reputation as miraculous molecules with preeminent beneficial effects on human health, for example, as antioxidants. However, there is little conclusive evidence that dietary flavonoids provide significant leads for developing more effective drugs, as the majority appears to be of negligible medicinal importance. Some aromatic polyketides of limited distribution have shown more interesting medicinal properties and additional research should be focused on them. Combretastatins, analogues of phenoxodiol, hepatoactive kavalactones, and silymarin are showing a considerable promise in the advanced phases of clinical trials for the treatment of various pathologies. If their limitations such as adverse side effects, poor water solubility, and oral inactivity are successfully eliminated, they might be prime candidates for the development of more effective and in some case safer drugs. This review highlights some of the newer compounds, where they are in the new drug pipeline and how researchers are searching for additional likely candidates.

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“…The electrode was formed on a screen-printed carbon paste on a plastic substrate. The area of the opening for the working electrode was 9 mm 2 . The details can be found in the literature.…”

Section: Electrode Preparationmentioning

confidence: 99%

“…1. The intake of theaflavin 1,2 as well as catechin 3,4 has healthy benefits, for example, the reduction of cardiovascular and chronic diseases. Therefore, analyses of the amount of total polyphenols are useful for the quality control of food and nutrition indications.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Analysis in Black Tea with a Carbon Nanotube Electrode

et al. 2019

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An electrochemical analysis of polyphenols (theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3′-gallate (TF2B), theaflavin-3,3′-digallate (TF3), and epigallocatechingallate (EGCG)) in a black tea infusion is demonstrated. The characterization of each polyphenol in a solution containing only a single type of polyphenol for a redox reaction at the CNT electrode with cyclic voltammetry (CV) was conducted. The oxidation peak at around +0.30 V for TF1 is assigned to catechol group in a benzotropolone ring. The oxidation peak at around +0.35 V for TF2A, TF2B, and TF3 is assigned to both of the catechol groups in the benzotropolone ring and the pyrogallol group in the gallate ring. The oxidation peak at around +0.35 V for EGCG is assigned to a pyrogallol group in the gallate ring. Current changes of those individual polyphenols at the peak potential are proportional to their concentrations (linear range 0.28-94 μM; detection limit 0.11 μM). The CV curve for real black tea, which is mainly composed of a mixture of the mentioned five compounds, is produced by the sum of those. The current change of the mixture solution of polyphenols is also proportional to the mass concentration of the total polyphenols and the sensitivity defined as the slope of current vs. concentration plot is independent of the ratio of the individual polyphenols. This indicates that the peak current at around +0.35 V can quantify the total amount of polyphenols in a black tea. Additionally, the shape of the CV curve can roughly estimate the ratio of [catechins]/[theaflavins]. The values for real samples determined from CVs show good agreement with that obtained by high-performance liquid chromatography.

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The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Cited by 22 publications

References 32 publications

Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice

Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice

Flavonoids and Related Members of the Aromatic Polyketide Group in Human Health and Disease: Do They Really Work?

Polyphenol Analysis in Black Tea with a Carbon Nanotube Electrode

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